The cortical spatiotemporal correlate of otolith stimulation: Vestibular evoked potentials by body translations

Ertl, Matthias; Moser, Matthias; Boegle, Rainer; Conrad, Julian; Eulenburg, Peter zu; Dieterich, Marianne

doi:10.1016/j.neuroimage.2017.02.044

Cited by 30 publications

(52 citation statements)

References 66 publications

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“…In contrast, our study utilized a more realistic experimental scenario, including both walking and standing conditions. In addition, we showed that the EEG power of theta, alpha, beta, and gamma bands increases significantly after noisy GVS in the vestibular cortex (LPL) both in healthy subjects and in patients, in line with the results of previous studies on GVS and gait-training [ 5 , 15 , 16 , 47 , 48 ]. The decrease, damage or decreased functionality of the vestibular system bilaterally affects the brain, making it difficult in maintaining body balance, particularly in patients during walking.…”

Section: Discussionsupporting

confidence: 90%

Noisy Galvanic Vestibular Stimulation (Stochastic Resonance) Changes Electroencephalography Activities and Postural Control in Patients with Bilateral Vestibular Hypofunction

Chikara

Chen

et al. 2020

Brain Sciences

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Patients with bilateral vestibular hypofunction (BVH) often suffer from imbalance, gait problems, and oscillopsia. Noisy galvanic vestibular stimulation (GVS), a technique that non-invasively stimulates the vestibular afferents, has been shown to enhance postural and walking stability. However, no study has investigated how it affects stability and neural activities while standing and walking with a 2 Hz head yaw turning. Herein, we investigated this issue by comparing differences in neural activities during standing and walking with a 2 Hz head turning, before and after noisy GVS. We applied zero-mean gaussian white noise signal stimulations in the mastoid processes of 10 healthy individuals and seven patients with BVH, and simultaneously recorded electroencephalography (EEG) signals with 32 channels. We analyzed the root mean square (RMS) of the center of pressure (COP) sway during 30 s of standing, utilizing AMTI force plates (Advanced Mechanical Technology Inc., Watertown, MA, USA). Head rotation quality when walking with a 2 Hz head yaw, with and without GVS, was analyzed using a VICON system (Vicon Motion Systems Ltd., Oxford, UK) to evaluate GVS effects on static and dynamic postural control. The RMS of COP sway was significantly reduced during GVS while standing, for both patients and healthy subjects. During walking, 2 Hz head yaw movements was significantly improved by noisy GVS in both groups. Accordingly, the EEG power of theta, alpha, beta, and gamma bands significantly increased in the left parietal lobe after noisy GVS during walking and standing in both groups. GVS post-stimulation effect changed EEG activities in the left and right precentral gyrus, and the right parietal lobe. After stimulation, EEG activity changes were greater in healthy subjects than in patients. Our findings reveal noisy GVS as a non-invasive therapeutic alternative to improve postural stability in patients with BVH. This novel approach provides insight to clinicians and researchers on brain activities during noisy GVS in standing and walking conditions in both healthy and BVH patients.

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Section: Discussionsupporting

confidence: 90%

Noisy Galvanic Vestibular Stimulation (Stochastic Resonance) Changes Electroencephalography Activities and Postural Control in Patients with Bilateral Vestibular Hypofunction

Chikara

Chen

et al. 2020

Brain Sciences

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“…Brandt 2015b) have identified the cortical network involved in the processing of vestibular input, electroencephalography (EEG) studies (McNerney et al 2011;Todd et al 2014Todd et al , 2016Kammermeier et al 2015;Ertl et al 2017) provided insight into the temporal dynamics of these processes. The excellent temporal resolution of EEG enabled the identification of early, middle and long latency potentials and their association with particular brain structures.…”

Section: Introductionmentioning

confidence: 99%

The role of delta and theta oscillations during ego-motion in healthy adult volunteers

et al. 2021

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The successful cortical processing of multisensory input typically requires the integration of data represented in different reference systems to perform many fundamental tasks, such as bipedal locomotion. Animal studies have provided insights into the integration processes performed by the neocortex and have identified region specific tuning curves for different reference frames during ego-motion. Yet, there remains almost no data on this topic in humans.In this study, an experiment originally performed in animal research with the aim to identify brain regions modulated by the position of the head and eyes relative to a translational ego-motion was adapted for humans. Subjects sitting on a motion platform were accelerated along a translational pathway with either eyes and head aligned or a 20° yaw-plane offset relative to the motion direction while EEG was recorded.Using a distributed source localization approach, it was found that activity in area PFm, a part of Brodmann area 40, was modulated by the congruency of translational motion direction, eye, and head position. In addition, an asymmetry between the hemispheres in the opercular-insular region was observed during the cortical processing of the vestibular input. A frequency specific analysis revealed that low-frequency oscillations in the delta- and theta-band are modulated by vestibular stimulation. Source-localization estimated that the observed low-frequency oscillations are generated by vestibular core-regions, such as the parieto-opercular region and frontal areas like the mid-orbital gyrus and the medial frontal gyrus.

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“…Most noteworthy was the observation that many studies overcame the risk of recruiting adextrals by taking precautionary measures to ensure that these participants did not introduce excessive noise to their results. A number of studies either included handedness as a covariate in formal statistical analyses of neuroimaging data (Amad et al., ; Arthursson et al., ; Blankenship, Redcay, Dougherty, & Riggins, ; Chahine, Richter, Wolter, Goya‐Maldonado, & Gruber, ; Ertl et al., ; Jacobs et al., ; Lenfeldt, Johansson, Domellöf, Riklund, & Rönnqvist, ; Petrican, Taylor, & Grady, ; Robinson et al., ; Schel & Klingberg, ; Skipper‐Kallal, Lacey, Xing, & Turkeltaub, ; Zhen et al., ), or reported on follow‐up analyses confirming that their main findings did not change as a result of removing adextral data (Carey, Krishnan, Callaghan, Sereno, & Dick, ; Goold & Meng, ; Romund et al., ; Zhong, He, Shu, & Gong, ). Moreover, a few studies concerned with language‐related processes (Amit, Hoeflin, Hamzah, & Fedorenko, ; Angenstein & Brechmann, ; Doucet, He, Sperling, Sharan, & Tracy, ) went so far as to conduct fMRI localiser scans to confirm the assumption of left‐sided language representation in all subjects.…”

Section: Discussionmentioning

confidence: 99%

A sinister subject: Quantifying handedness‐based recruitment biases in current neuroimaging research

Bailey

McMillan

Newman

2019

Eur J of Neuroscience

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Approximately ten per cent of humans are left‐handed or ambidextrous (adextral). It has been suggested that, despite their sizable representation at the whole‐population level, this demographic is largely avoided by researchers within the neuroimaging community. To date, however, no formal effort has been made to quantify the extent to which adextrals are excluded from neuroimaging‐based research. Here, we aimed to address this question in a review of over 1,000 recent articles published in high‐impact, peer‐reviewed, neuroimaging‐focused journals. Specifically, we sought to ascertain whether, and the extent to which adextrals are underrepresented in neuroimaging study samples, and to delineate potential trends in this bias. Handedness data were available for over 30,000 research subjects; only around 3%–4% of these individuals were adextral—considerably less than the 10% benchmark one would expect if neuroimaging samples were truly representative of the general population. This observation was generally consistent across different areas of research, but was modulated by the demographic characteristics of neuroimaging participants. The epistemological and ethical implications of these findings are discussed.

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The cortical spatiotemporal correlate of otolith stimulation: Vestibular evoked potentials by body translations

Cited by 30 publications

References 66 publications

Noisy Galvanic Vestibular Stimulation (Stochastic Resonance) Changes Electroencephalography Activities and Postural Control in Patients with Bilateral Vestibular Hypofunction

Noisy Galvanic Vestibular Stimulation (Stochastic Resonance) Changes Electroencephalography Activities and Postural Control in Patients with Bilateral Vestibular Hypofunction

The role of delta and theta oscillations during ego-motion in healthy adult volunteers

A sinister subject: Quantifying handedness‐based recruitment biases in current neuroimaging research

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