The cortical connectome of primate lateral prefrontal cortex

Xu, Rui; Bichot, Narcisse P.; Takahashi, Atsushi; Desimone, Robert

doi:10.1016/j.neuron.2021.10.018

Cited by 32 publications

(38 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fig. S3E and 3F show that these topographic projections are impressively similar to those reported for macaque lateral PFC 23 . We also found orderly relationships in the distribution of columnar patches within frontal cortex (Fig.…”

Section: Columnar Projections Recapitulate Pfc Topographic Gradients ...supporting

confidence: 79%

“…This data conversion highlighted the orthogonal relationships of NMF_W1 through W4 (Figure 4F). Furthermore, we employed the 2D color index strategy (Xu et al, 2022) to represent the various contributions of W1 through W4 (Figure 4G), which successfully displayed the four components in a single map (Figure 4H, right panel). We also used this strategy to show the coefficient values at each injection point (Figure 4H, left panel).…”

Section: Resultsmentioning

confidence: 99%

“…The topographic organization has been considered to be a key organizing principle for various extrinsic projections (Barbas, 2015b; Borra et al, 2019; Ferry et al, 2000; Goldman-Rakic; Haber, 2016; Oligschläger et al, 2019; Phillips et al, 2019; Roberts et al, 2007; Romanski et al, 1999; Selemon and Goldman-Rakic, 1985; Siwek and Pandya, 1991) and functional properties (Badre and D’Esposito, 2009; Huntenburg et al, 2018; Riley et al, 2018) of the primate PFC. Recently, a dense mapping of the macaque lateral PFC by electrical microstimulation-fMRI found mirroring of the PFC layout in major association cortices (Xu et al, 2022). Our data suggest that such mirroring may extend beyond the lateral PFC and also involve the medial and orbital domains.…”

Section: Discussionmentioning

confidence: 99%

“…Topographic organization has been proposed as a key organizing principle for various PFC extrinsic projections 31,36,38,[40][41][42][43] and functional properties [44][45][46] . Recently, a mapping of the macaque lateral PFC by electrical microstimulation-fMRI reported mirroring of lateral PFC maps in five association cortex regions 23 . Our data suggest that such mirroring also occurs for at least three cortical regions in the marmoset, likely involves orbitomedial PFC as well, and also applies to corticostriatal connections.…”

Section: Topographic Gradients In the Primate Brainmentioning

confidence: 99%

See 3 more Smart Citations

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Watakabe

Skibbe

Nakae

et al. 2021

Preprint

View full text Add to dashboard Cite

The primate prefrontal cortex (PFC) has greatly expanded to evolve specialized architecture, but its roles in top-down brain control remain enigmatic. Based on connectomics mapping of the marmoset PFC, we characterized two contrasting features of corticocortical and corticostriatal projections. One is the "focalness" of projections, exemplified by multiple columnar axonal terminations in the cortical layers and the other is the "widespreadness" of weaker projections, whose patterns consisted of several common motifs representing the framework of PFC connectivity. We clarified the topographic rules of distribution for these features, which should constrain how PFC neurons can coordinate to control the target regions as populations. These features are observed only primitively in rodents and are considered critical in understanding the roles of the PFC in neuropsychiatric disorders.

show abstract

Section: Columnar Projections Recapitulate Pfc Topographic Gradients ...supporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Topographic Gradients In the Primate Brainmentioning

confidence: 99%

See 2 more Smart Citations

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Watakabe

Skibbe

Nakae

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This view leads to potential insights about functional organization of brain areas without the limitations of a recording chamber (Milham et al, 2022). For example, in recent literature, fMRI has enabled the mapping of projections to and from the PFC with a level of specificity and across distances not previously possible on this scale (Xu et al, 2022). This work found an overlap in topographically organized high-level visual maps from the dorsal and ventral streams in primate lateral prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Monkey dorsolateral prefrontal cortex represents abstract visual sequences during a no-report task

Rodriguez

McKim

Basu

et al. 2022

Preprint

View full text Add to dashboard Cite

Monitoring sequential information is an essential component of our daily lives. Many of these sequences are abstract, in that they do not depend on the individual stimuli, but do depend on an ordered set of rules (e.g., chop then stir when cooking). Despite the ubiquity and utility of abstract sequential monitoring, little is known about its neural mechanisms. Human rostrolateral prefrontal cortex (RLPFC) exhibits specific increases in neural activity (i.e., "ramping") during abstract sequences. Monkey dorsolateral prefrontal cortex (DLPFC) has been shown to represent sequential information in motor (not abstract) sequence tasks, and contains a sub-region, area 46, with homologous functional connectivity to human RLPFC. To test the prediction that area 46 may represent abstract sequence information, and do so with parallel dynamics to those found in humans, we conducted functional magnetic resonance imaging (fMRI) in monkeys. When monkeys performed no-report abstract sequence viewing, we found that right area 46 responded to both abstract sequential rule and number changes. Interestingly, left area 46 exhibited ramping activation similar to that observed in humans that also indicated abstract sequential rule changes. Together, these results indicate that monkey DLPFC monitors abstract visual sequential information, and may do so through unique, hemisphere-specific neural mechanisms. More generally, these results show that abstract sequences are represented in functionally homologous regions across monkeys and humans.

show abstract

Neural correlates of fine motor grasping skills: Longitudinal insights into motor cortex activation using fNIRS

Li,

Jin,

Zhang

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundMotor learning is essential for performing specific tasks and progresses through distinct stages, including the rapid learning phase (initial skill acquisition), the consolidation phase (skill refinement), and the stable performance phase (skill mastery and maintenance). Understanding the cortical activation dynamics during these stages can guide targeted rehabilitation interventions.MethodsIn this longitudinal randomized controlled trial, functional near‐infrared spectroscopy was used to explore the temporal dynamics of cortical activation in hand‐related motor learning. Thirty‐one healthy right‐handed individuals were randomly assigned to perform either easy or intricate motor tasks with their non‐dominant hand over 10 days. We conducted 10 monitoring sessions to track cortical activation in the right hemisphere (according to lateralization principles, the primary hemisphere for motor control) and evaluated motor proficiency concurrently.ResultsThe study delineated three stages of nondominant hand motor learning: rapid learning (days 1 and 2), consolidation (days 3–7), and stable performance (days 8–10). There was a power‐law enhancement of motor skills correlated with learning progression. Sustained activation was observed in the supplementary motor area (SMA) and parietal lobe (PL), whereas activation in the right primary motor cortex (M1R) and dorsolateral prefrontal cortex (PFCR) decreased. These cortical activation patterns exhibited a high correlation with the augmentation of motor proficiency.ConclusionsThe findings suggest that early rehabilitation interventions, such as transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), could be optimally directed at M1 and PFC in the initial stages. In contrast, SMA and PL can be targeted throughout the motor learning process. This research illuminates the path for developing tailored motor rehabilitation interventions based on specific stages of motor learning.NEW and NOTEWORTHYIn an innovative approach, our study uniquely combines a longitudinal design with the robustness of generalized estimating equations (GEEs). With the synergy of functional near‐infrared spectroscopy (fNIRS) and the Minnesota Manual Dexterity Test (MMDT) paradigm, we precisely trace the evolution of neural resources during complex, real‐world fine‐motor task learning. Centering on right‐handed participants using their nondominant hand magnifies the intricacies of right hemisphere spatial motor processing. We unravel the brain's dynamic response throughout motor learning stages and its potent link to motor skill enhancement. Significantly, our data point toward the early‐phase rehabilitation potential of TMS and transcranial direct current stimulation on the M1 and PFC regions. Concurrently, SMA and PL appear poised to benefit from ongoing interventions during the entire learning curve. Our findings carve a path for refined motor rehabilitation strategies, underscoring the importance of timely noninvasive brain stimulation treatments.

show abstract

The cortical connectome of primate lateral prefrontal cortex

Cited by 32 publications

References 125 publications

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Monkey dorsolateral prefrontal cortex represents abstract visual sequences during a no-report task

Neural correlates of fine motor grasping skills: Longitudinal insights into motor cortex activation using fNIRS

Contact Info

Product

Resources

About