The correlations between psychological distress, cognitive impairment and quality of life in patients with brain metastases after whole-brain radiotherapy

Yao, Senbang; Zuo, He; Li, Wen; Cai, Yu; Zhang, Qianqian; Pang, Lulian; Jing, Yanyan; Yin, Xiangxiang; Huang, Cheng

doi:10.1007/s12094-022-02927-3

Cited by 2 publications

(2 citation statements)

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“…Although RT is essential in the management of patients with brain tumors, it leads to cognitive declines that dramatically alter the quality of life of those treated patients [ 2 , 3 ]. To improve the management of brain sequalae caused by RT, it is crucial to propose sensitive tools that detect irradiation-associated brain damage.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation toxicities appear at different times following RT: acute effects from days to weeks with fatigue and variable psycho-cognitive changes, then early effects from 1 to 6 months after RT, especially manifest and progressive cognitive deficits and finally late effects can appear several months or years after RT corresponding to permanent cognitive disabilities [ 1 ]. Cranial RT induces cognitive decline associated with a reduction in the quality of life of long-surviving patients [ 2 , 3 ]. Several preclinical studies evidenced that brain irradiation causes vascular lesions, white matter necrosis, demyelination, inflammation, neurogenesis alterations and neurodegeneration [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?

Brunaud,

Valable,

Ropars

et al. 2024

Cancer Imaging

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Background Radiotherapy is a major therapeutic approach in patients with brain tumors. However, it leads to cognitive impairments. To improve the management of radiation-induced brain sequalae, deformation-based morphometry (DBM) could be relevant. Here, we analyzed the significance of DBM using Jacobian determinants (JD) obtained by non-linear registration of MRI images to detect local vulnerability of healthy cerebral tissue in an animal model of brain irradiation. Methods Rats were exposed to fractionated whole-brain irradiation (WBI, 30 Gy). A multiparametric MRI (anatomical, diffusion and vascular) study was conducted longitudinally from 1 month up to 6 months after WBI. From the registration of MRI images, macroscopic changes were analyzed by DBM and microscopic changes at the cellular and vascular levels were evaluated by quantification of cerebral blood volume (CBV) and diffusion metrics including mean diffusivity (MD). Voxel-wise comparisons were performed on the entire brain and in specific brain areas identified by DBM. Immunohistology analyses were undertaken to visualize the vessels and astrocytes. Results DBM analysis evidenced time-course of local macrostructural changes; some of which were transient and some were long lasting after WBI. DBM revealed two vulnerable brain areas, namely the corpus callosum and the cortex. DBM changes were spatially associated to microstructural alterations as revealed by both diffusion metrics and CBV changes, and confirmed by immunohistology analyses. Finally, matrix correlations demonstrated correlations between JD/MD in the early phase after WBI and JD/CBV in the late phase both in the corpus callosum and the cortex. Conclusions Brain irradiation induces local macrostructural changes detected by DBM which could be relevant to identify brain structures prone to radiation-induced tissue changes. The translation of these data in patients could represent an added value in imaging studies on brain radiotoxicity.

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Section: Discussionmentioning

confidence: 99%