The correlation of triglyceride/high-density lipoprotein cholesterol ratio with muscle mass in type 2 diabetes patients

Fu, Qingsong; Zhang, Zhenwen; Hu, Wenchao; Yang, Yinrong

doi:10.1186/s12902-023-01349-8

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Obesity is related to and impacts diabetes. Patients with diabetes are prone to abnormal blood lipid levels, as fat synthesis is reduced, degradation is accelerated and disorders of lipid metabolism cause an increase in blood lipids ( 143 ). In diabetes, large amounts of fatty acids and glycerol enter the liver due to accelerated fat degradation with a decrease in the insulin/glucagon ratio.…”

Section: Lipid Metabolism Disorders In Osteoporotic Patients With Dia...mentioning

confidence: 99%

Obesity and lipid metabolism in the development of osteoporosis (Review)

Wang,

Zhang,

Zhao

et al. 2024

Int J Mol Med

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Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator-activated receptor γ and Wnt/β-catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis. Lipid substances play an important role in the occurrence and development of osteoporosis. The content and proportion of lipids modulate the activity of immunocytes, mainly macrophages, and the secretion of inflammatory factors, such as IL-1, IL-6 and TNF-α. These inflammatory effectors increase the activity and promote the differentiation of osteoclasts, which leads to bone imbalance and stronger bone resorption. Obesity also decreases the activity of antioxidases and leads to oxidative stress, thereby inhibiting osteogenesis. The present review starts by examining the bidirectional differentiation of BM-MScs, describes in detail the mechanism by which lipids affect bone metabolism, and discusses the regulatory role of inflammation and oxidative stress in this process. The review concludes that a reasonable adjustment of the content and proportion of lipids, and the alleviation of inflammatory storms and oxidative damage induced by lipid imbalances, will improve bone mass and treat osteoporosis. Contents1. Introduction 2. Obesity-induced osteoporosis 3. Balance of osteogenesis and adipogenesis 4. Hyperlipemia-induced pathological changes and osteoporosis 5. Lipids and osteoporosis 6. Obesity in postmenopausal osteoporosis 7. Lipid metabolism disorders in osteoporotic patients with diabetes 8. discussion

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Section: Lipid Metabolism Disorders In Osteoporotic Patients With Dia...mentioning

confidence: 99%

Obesity and lipid metabolism in the development of osteoporosis (Review)

Wang,

Zhang,

Zhao

et al. 2024

Int J Mol Med

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“…2,3 The overall prevalence of sarcopenia varied from 10.4% to 28.8% among type 2 diabetic patients in China. [4][5][6] Sarcopenia is associated with poor outcomes in patients with diabetes, including chronic kidney disease (CKD), diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), atherosclerosis, cognitive impairment, infection, and mortality. [7][8][9][10] Therefore, early recognition and intervention of sarcopenia are essential to improve the prognosis of patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Assessment of the Gastrocnemius Muscle as a Potential Tool for Identifying Sarcopenia in Patients with Type 2 Diabetes

Wei,

Xie,

Cao

et al. 2023

DMSO

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This study aims to examine the clinical significance of ultrasound evaluation of the gastrocnemius muscle (GM) in identifying sarcopenia in patients with type 2 diabetes (T2D). Methods: One hundred and fifty-three patients with T2D were included in this study. We measured the appendicular skeletal muscle mass index (ASMI), handgrip strength, and 6-meter walking speed. The US-derived muscle thickness (MT), cross-sectional area (CSA), and shear wave ultrasound elastography (SWE) of GM were also measured. We assessed the correlations between clinical indicators and US features. The model for screening sarcopenia was established using stepwise logistic regression. Stepwise linear regression was used to identify a set of variables that jointly estimated ASMI. The model's ability to identify sarcopenia and low muscle mass was assessed by receiver operating characteristic (ROC) curve analysis. Results: The prevalence of sarcopenia in this study was 24.2%. The CSA, MT and SWE values of the patients with sarcopenia were lower than those of patients without sarcopenia (all p < 0.05). ASMI was positively correlated with CSA (r = 0.56, p < 0.001) and MT (r = 0.39, p < 0.001). Handgrip strength was positively correlated with CSA (r = 0.45, p < 0.001), MT (r = 0.25, p < 0.001), and SWE (r = 0.26, p = 0.002). A diagnostic model for sarcopenia was established with a sensitivity of 81.1%, specificity of 75.0%, and an area under the curve (AUC) of 0.800. The estimated ASMI equation was developed and found to have a positive correlation with actual ASMI (r = 0.70, p < 0.001). It was also effective in diagnosing low muscle mass, with an AUC of 0.787 for males and 0.783 for females. Conclusion: Ultrasonographic assessment of the gastrocnemius muscle was found to be a useful and convenient method for detecting sarcopenia in patients with T2D.

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