The correlation of the radiologic extent of lung transplantation edema with pulmonary oxygenation.

Abstract

OBJECTIVE. The studysetout to evaluatethe relationshipbetweenthe efficiencyof pul monary oxygenation and the extent of the reimplantation response as revealed on chest radi ography after bilateral lung transplantation.MATERIALS AND METHODS. Postoperativechestradiographsof 31 patientswho had undergone bilateral lung transplantation were evaluated for the extent of the reimplanta tion response. For each patient, the contemporaneous oxygenation indexes (partial pressure of oxygenin arterialblood divided by fraction of inspiredoxygen)werecalculatedandcorre lated with a radiographic score produced from the evaluation of chest radiographs. RESULTS. The methodof evaluatingchestradiographs for theextentof thereimplantationresponse was shown to be reproducible. Although mean oxygenation indexes were found to de creasewith increasing radiographic scores, thistrendwasnot statisticallysignificant.CONCLUSION. Althoughtheextentof the reimplantationresponse on theearly postop erative chest radiography inversely correlated with the oxygenation efficiency of the trans planted lungs, this finding was not statistically significant.

Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating the Calcium-Sensing Receptor

“…I conclusion, the preservation of ELF thickness at ~0.2μm suggests the involvement of exquisite homeostatic regulations by lung epithelia involving ENaC, CFTR, and Na,K-ATPase. Impairment of lung epithelia ion channels and Na,K-ATPase function leads to pulmonary edema [61,87,88], a serious complication triggered by many diseases and various types of traumata initiated by inhaled or aspirated particles, pathogens and toxic gases [89][90][91][92]. The precise occurrence and the associated morbidity and mortality of pulmonary edema are difficult to quantitate, as it is associated with such a wide variety of conditions.…”