The correlation of the platelet-to-lymphocyte ratio with the severity of stenosis and stroke in patients with carotid arterial disease

Abstract

Objectives Platelet-to-lymphocyte ratio is a novel biomarker, recently shown to be correlated with atherosclerotic inflammation. This study investigated the role of platelet-to-lymphocyte ratio in patients with carotid artery stenosis and stroke. Methods Patients, who underwent carotid angiography with Multiple Detector Computed Tomography Angiography at our hospital, were retrospectively screened. Patients enrolled were divided into three groups based on the platelet-to-lymphocyte ratio. Patients with a platelet-to-lymphocyte ratio value between 55.0 and 106.71 were assigned to Group I, patients with a platelet-to-lymphocyte ratio value between 106.79 and 160.61 were assigned to Group II and patients with a platelet-to-lymphocyte ratio value between 162.96 and 619.61 were assigned to Group III. The carotid arterial stenosis calculated was classified as per the criteria of North American Symptomatic Carotid Endarterectomy Trial. Results One hundred fifty patients were included in our trial (mean age 61.9 ± 13.1 with 104 males). The rate of carotid arterial stenosis was detected to be higher in patients with a high platelet-to-lymphocyte ratio value (p = 0.010). Additionally, the platelet-to-lymphocyte ratio was positively correlated with the carotid arterial stenosis percentage (r = 0.250, p = 0.002). In the multi-variate regression analysis, platelet-to-lymphocyte ratio was detected to be an independent variable with respect to stroke (odd's ratio = 1.012, confidence interval = 1.001-1.024, p = 0.031). Conclusions Increased platelet-to-lymphocyte ratio could be a simple and practical marker of the clinical course in patients with carotid arterial stenosis.

Higher Platelet-to-Lymphocyte Ratio Is Associated With Worse Outcomes After Intravenous Thrombolysis in Acute Ischaemic Stroke

“…In the study of cerebrovascular diseases, an increased PLR was considered a predictor of stroke (35). Studies have suggested that low PLR levels could be a highly negative predictive value to rule out stroke events for patients with carotid artery stenosis (CAS) (36). In another study, high PLR values could indirectly estimate the infarcted size of stoke patients and the poor recanalization rate after thrombectomy therapy (13).…”

The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

“…For this purpose, the fasting blood glucose, lipid profile, complete blood count and total testosterone level that are requested by clinicians are among these tests (Burnett, ). Studies conducted on NLR and PLR values, which show the relation between systemic inflammation and many diseases in ED and aetiology, are increasing in the present literature (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ). When we selected our study group, we included not only the pre‐treatment values, but also those who were asked for a CBC for any reason to determine the changes in the 1st month after PDE5i treatment, which is different from previous studies.…”

“…Idil Soylu et al conducted a study and showed that the PLR rate was positively correlated with carotid arterial stenosis ( r = 0.250, p = 0.002) (İdil Soylu et al, ). Mertoğlu et al showed that the mean NLR values were statistically higher in patients with pre‐diabetes (1.60 ± 0.85) and those who were diagnosed newly (1.58 ± 0.78) and in patients with diabetes (2.07 ± 0.95) when compared to the normal group (1.37 ± 0.69); and the mean PLR value was higher in the diabetic group (122.45 ± 37.43) (Mertoglu & Gunay, ).…”

“…In recent years, publications indicating that active inflammatory processes cause ED are increasing. In these studies where neutrophil–lymphocyte (NLR) and platelet–lymphocyte ratios (PLR) were used as signs of inflammation, a significant relationship was found between diseases with these proportions (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Sambel et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ).…”

The association between platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and carotid artery stenosis and stroke following carotid endarterectomy

“…6 Platelet/lymphocyte ratio (PLR) is considered to be a recent biomarker which is not only related with inflammation but also associated with the atherosclerotic process which may lead to plaque rupture. 7 In some studies, a positive clinical correlation was found between PLR count and the incidence of coronary artery disease, 8 the degree of carotid artery stenosis, 9,10 the incidence of peripheral artery disease, 11,12 and the incidence of aortic valve stenosis. 13 However, data on the association between PLR and carotid artery stenosis in patients undergoing carotid endarterectomy (CEA) are lacking.…”