2016
DOI: 10.1016/j.anndiagpath.2016.04.002
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Aylin Yazgan, Nilüfer Yıldırım, Ayşegül Gözalan, Sinem Gümüştaş, Aydan Kılıçarslan, Serdar Balci, Cevdet Aydın, Reyhan Ersoy, Bekir Cakir, Gülnur Güler

Abstract: BRAF(V600E) mutation was analyzed by real-time polymerase chain reaction in 96 consecutive cases with classical variant papillary thyroid cancer, and immunohistochemical staining of Na+/I- symporter (NIS) protein was evaluated. Localization (intracellular or membranous), density, and the intensity of cytoplasmic staining were characterized semiquantitatively. Extrathyroidal invasion, surgical margin positivity, and lymph node metastasis were compared with BRAF(V600E) mutation and NIS expression. Eighty-eight p…

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