The Correlation of Serum Brain Natriuretic Peptide and Interleukin-6 with Quality of Life Using the Chronic Obstructive Pulmonary Disease Assessment Test

Abstract

Objective: The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using the COPD assessment test (CAT). Materials and Methods: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP and serum IL-6 levels, pulmonary function, and oxygen saturation (SpO₂) were measured according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and CAT score. Also, the associations of both pro-BNP and IL-6 with the clinical parameters of patients were tested. Results: The serum levels of IL-6 (7.57 [5-11.16] pg/mL) and pro-BNP (120.55 [92.89-144.20] pg/mL) were higher with enhancing disease severity based on the GOLD classification (p = 0.034 and 0.068, respectively). Also, serum levels of pro-BNP (120.55 [89.50-147.90] pg/mL) and IL-6 (6.68 [4.40-11.97] pg/mL) were increased in patients with high CAT scores (p = 0.004 and 0.017, respectively). There was a significant positive correlation between plasma pro-BNP and IL-6 levels (r = 0.332, p = 0.002). Conclusion: The results demonstrated that with increased severity of obstruction based on the GOLD criteria both IL-6 and pro-BNP were elevated. This increase in inflammatory markers was associated with a reduced quality of life and the severity of hypoxia. These findings indicated that lowering IL-6 and pro-BNP could be useful in the management of COPD patients.

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

“…The elevated levels of IL-6 and IL-8 in the serum of subjects with BNP gene rs198389, rs6668352, and rs198388 mutations in the present study indicate that these SNPs are involved in the development of inflammatory response and may contribute to COPD. Ghobadi et al [ 33 ] showed that the levels of serum IL-6 and pro-BNP increased with the severity of COPD, and the results were consistent with the results of the present study.…”

Diet-induced obesity in animal models: points to consider and influence on metabolic markers

“…In this way, some of the evaluated studies noticed an increase in the serum concentration of triglycerides [ 1 , 2 , 9 , 16 , 17 , 21 – 23 , 25 , 35 , 51 , 61 , 63 ] and cholesterol [ 2 , 9 , 16 , 23 , 27 , 29 , 35 , 51 , 61 , 63 ] in the groups fed with DIO. This change seems to be especially related to saturated fatty acid-rich [ 27 ] obesogenic diets (Table 2 ).…”

“…This inflammatory condition contributes to the development of metabolic disorders [ 1 , 35 ], such as diabetes [ 27 ]; to a decrease in lymphatic function and cutaneous hypersensitivity [ 34 ]; and to the occurrence of other diseases, such as periodontitis [ 62 ] and respiratory allergies [ 63 ]. Furthermore, the immune system can also be altered, with an improvement in this system when there is a modulation of the production of inflammatory cytokines [ 64 ].…”

Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology

“…IL-6 is an important marker of the inflammatory response. Ghobadi et al [23] found a higher level of IL-6 in the serum with a more severe COPD condition. These results indicate that IL-6 has an important role in the development of COPD.…”