The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men

Kazemi, Fahimeh

doi:10.1007/s40618-015-0373-9

Cited by 26 publications

(18 citation statements)

References 28 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, it appears that the hepatic insulin resistance revealed by IR HOMA as well as the rise of plasma glucose and insulin in the early phase of OGTT is relatively less in RES compared with SIE. This is in agreement with recent findings of a reduction in IR HOMA 24 hours following a circuit resistance exercise program [28]. Moreover, despite the difference in the increase in Cederholm and Gutt indices between RES and SIE not achieving statistical significance level, the increase in peripheral insulin sensitivity from the CON level tends to be higher following RES (Cohen's d effect size: Cederholm 0.5, Gutt 0.5) than SIE (0.36, 0.43).…”

Section: Discussionsupporting

confidence: 94%

Comparable Effects of Brief Resistance Exercise and Isotime Sprint Interval Exercise on Glucose Homeostasis in Men

Tong

Kong

Shi

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

This study compared the effects of a single bout of resistance exercise (RES) on glycemic homeostasis to isotime sprint interval exercise (SIE) using a within-subjects design. Nineteen nondiabetic males (age: 23.3 ± 0.7 yrs; height: 173.1 ± 1.2 cm; weight: 79.1 ± 4.8 kg; % fat: 22.5 ± 2.5%) were studied. RES involved nine exercises of 10 repetitions at 75% 1-RM using a 2 : 2 s tempo and was interspersed with a one-minute recovery; SIE involved four 30 s' all-out cycling effort interspersed with four minutes of active recovery. Plasma glucose and insulin in response to a 75 g oral glucose tolerance test were assessed 12 h after exercise. In comparison to a no exercise control trial (CON), the area under curve (AUC) of plasma glucose was reduced with both RES and SIE (P < 0.05), while insulin AUC was only reduced with RES. Cederholm, Gutt, Matsuda, and HOMA indices were improved (P < 0.05) following RES compared to CON. Corresponding changes following SIE were only found in Cederholm and Gutt indices (P < 0.05). No difference was found in plasma variables and indices between RES and SIE (P > 0.05). Such findings suggest that the RES may represent a potential alternative to the SIE in the development of time-efficient lifestyle intervention strategies for improving diabetes risk factors in healthy populations.

show abstract

Section: Discussionsupporting

confidence: 94%

Comparable Effects of Brief Resistance Exercise and Isotime Sprint Interval Exercise on Glucose Homeostasis in Men

Tong

Kong

Shi

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…It is abundantly expressed in skeletal muscles, but is also expressed to a lesser extent in cardiac muscles and fat tissues (McPherron et al, 1997; Sharma et al, 1999). Myostatin levels in the plasma of healthy young men has been shown to significantly decrease within 24 h post-exercise when compared to pre-exercise and has also been shown to positively correlate with plasma IL-6 (Kazemi, 2016). In contrast, serum myostatin has been shown to increase in patients with spinal cord injury after aerobic exercise (Han et al, 2016).…”

Section: Myostatinmentioning

confidence: 99%

Role of Myokines in Regulating Skeletal Muscle Mass and Function

2019

View full text Add to dashboard Cite

Loss of skeletal muscle mass and strength has recently become a hot research topic with the extension of life span and an increasingly sedentary lifestyle in modern society. Maintenance of skeletal muscle mass is considered an essential determinant of muscle strength and function. Myokines are cytokines synthesized and released by myocytes during muscular contractions. They are implicated in autocrine regulation of metabolism in the muscle as well as in the paracrine/endocrine regulation of other tissues and organs including adipose tissue, the liver, and the brain through their receptors. Till date, secretome analysis of human myocyte culture medium has revealed over 600 myokines. In this review article, we summarize our current knowledge of major identified and characterized myokines focusing on their biological activity and function, particularly in muscle mass and function.

show abstract

“…Literature has characterized the influence of exercise on myostatin concentration as ambiguous. Kazemi et al reported that a single session of high-volume circuit resistance training resulted in a significant decrease in plasma myostatin 24 h after exercise [ 38 ]. Contrarily, according to Willoughby et al, a single session of eccentric muscle actions caused an increase in serum myostatin concentration with peak values recorded 24 h post exercise [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Resistance Training Supported by Whole-Body Cryostimulation Induced a Decrease in Myostatin Concentration and an Increase in Isokinetic Muscle Strength

Jaworska

Rodziewicz-Flis

Kortas

et al. 2020

IJERPH

View full text Add to dashboard Cite

The study aimed to determine whether combining cryostimulation with resistance training would effectively increase muscle strength, and if so, whether this adaptation would be related to changes in circulating levels of exerkines (i.e., mediators of systemic adaptation to exercise). Twenty-five students completed 12 sessions of resistance training, each followed by either cryostimulation (n = 15, 3 min exposure at −110 °C) or passive recovery (n = 10). Prior to and post this intervention, participants performed two eccentric cycling bouts (before and after training). At these points, serum concentrations of muscle damage marker (myoglobin), exerkines (interleukin 6 (IL-6), interleukin 15 (IL-15), irisin, brain-derived neurotrophic factor), hypertrophy-related factors (myostatin, insulin-like growth factor 1), and muscle strength were measured. The applied procedure reduced the physiological burden of the second eccentric cycling bout and myoglobin concentrations only in the group subject to cryostimulation. The same group also exhibited decreased levels of myostatin (from 4.7 ± 1.7 to 3.8 ± 1.8 ng·mL−1, p < 0.05). A significant and large interaction between the group × time was noted in IL-15 concentration (p = 0.01, ηp2= 0.27). Training and cryostimulation induced a positive and likely significant improvement of isokinetic muscle strength. Altogether, obtained results support the claim that resistance training combined with cold exposure modified muscle strength through modulation of myostatin and IL-15 concentrations.

show abstract

The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men

Abstract: It seems that a circuit RE bout by reducing HOMA-IR and changing plasma cytokines (decreased IL-6 and increased IL-10) can decrease plasma level of MSTN in healthy young men. In other word, the beneficial effect of acute RE may be reflected by changes in MSTN in healthy young individuals.

Cited by 26 publications

References 28 publications

Comparable Effects of Brief Resistance Exercise and Isotime Sprint Interval Exercise on Glucose Homeostasis in Men

Comparable Effects of Brief Resistance Exercise and Isotime Sprint Interval Exercise on Glucose Homeostasis in Men

Role of Myokines in Regulating Skeletal Muscle Mass and Function

Short-Term Resistance Training Supported by Whole-Body Cryostimulation Induced a Decrease in Myostatin Concentration and an Increase in Isokinetic Muscle Strength

Contact Info

Product

Resources

About