The Correlation of Renal Allograft Weight to Metabolic Index Ratios and Glomerular Filtration Rate Among Living-Unrelated Kidney Transplant Patients: A Cross-Sectional Study

Amante, Angel J.; Piñon-Barretto, S.C.

doi:10.1016/j.transproceed.2008.07.071

Cited by 16 publications

(16 citation statements)

References 11 publications

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“…Donor gender was the factor that revealed the most differences in the parameters analyzed with male donors being heavier and male grafts with higher weight and volumes. These values are consistent with most of the published studies [11,12,15,16]. The relationships between these weights and the indicators of the recipient metabolic demands (Kw/Rw, Kv/Rw, and Dw/Rw) were also significantly higher in males.…”

Section: Discussionsupporting

confidence: 91%

Small Kidneys for Large Recipients: Does Size Matter in Renal Transplantation?

Dinis¹,

Nunes²,

Furriel³

et al. 2015

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 91%

Small Kidneys for Large Recipients: Does Size Matter in Renal Transplantation?

Dinis¹,

Nunes²,

Furriel³

et al. 2015

Transplantation Proceedings

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“…Previous studies examining donor-recipient size mismatch suggested a graft survival advantage for kidney recipients who receive larger organs in relation to their own body size 9–11. An early study described the magnitude of advantage comparable to the benefits for grafts implanted within 48 hours of procurement as well as HLA matched grafts 15.…”

Section: Discussionmentioning

confidence: 99%

“…Also, several investigations have suggested a graft survival advantage for recipients receiving larger kidneys relative to their body size 9–11. Compared to males, females usually have smaller kidneys 12–14.…”

Section: Introductionmentioning

confidence: 99%

Donor-Recipient Gender and Size Mismatch Affects Graft Success after Kidney Transplantation

McGee

Magnus

Islam

et al. 2010

Journal of the American College of Surgeons

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Background Female recipients of male kidneys have an inferior graft survival, and patients receiving larger kidneys relative to their body size may have a graft survival advantage. Thus, graft survival may be affected by both gender and kidney size mismatches. The objective of this study was to analyze the possible confounding effect of body mass mismatch (body mass as proxy for kidney size) between female recipients of male donor kidneys. Study Design A total of 668 kidney transplants between 1996 and 2005 at our center were studied retrospectively. Graft and patient survival were determined by Kaplan-Meier estimation. Multivariate Cox proportional analyses were performed to determine the hazards of graft loss. Results There were 146 female recipients of male kidneys. Compared to all gender combinations, this group had the lowest, unadjusted graft survival (86%, 79%, and 78% vs. 92%, 88%, and 86% at 1, 2, and 3 years, respectively, log-rank p=0.01). Donor body mass index (BMI) correlated with donor kidney size (p<0.001). Male kidneys were a risk factor of graft loss for female recipients (hazard ratio [HR] 3.45, 95% CI 1.40–8.51, p=0.01), but male donors with a larger BMI relative to female recipients’ significantly reduced the risk (HR 0.19, 95% CI 0.05–0.67, p=0.01). Conclusions The inferior graft survival for female recipients of male donor kidneys is mitigated by male donors with a larger BMI.

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“…37 The key to understanding such an effect of BMI on graft function after transplant may lie in treating it as an issue of the relationship between renal allograft weight to BMI and GFR. 38,39 Amante and associates 40 suggested that grafting a relatively smaller living-donor kidney into a heavy recipient may be a risk factor for allograft failure and that a minimum renal allograft weight-to-recipient body weight ratio of 8.2 or more predicted a good GFR after transplant. 40 In a retrospective observational study of 310 patients, the donor-to-recipient BMI ratio was lower in the patient group with slow graft function than in the group with immediate graft function (P < .001).…”

Section: Body Mass Indexmentioning

confidence: 99%

“…38,39 Amante and associates 40 suggested that grafting a relatively smaller living-donor kidney into a heavy recipient may be a risk factor for allograft failure and that a minimum renal allograft weight-to-recipient body weight ratio of 8.2 or more predicted a good GFR after transplant. 40 In a retrospective observational study of 310 patients, the donor-to-recipient BMI ratio was lower in the patient group with slow graft function than in the group with immediate graft function (P < .001). 28 Lee and associates also reported that graft kidney volume-to-recipient body surface area ratio is significantly associated with graft function.…”

Section: Body Mass Indexmentioning

confidence: 99%

Untitled

2016

Exp Clin Transplant

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With an increased incidence of living-donor kidney transplants, in response to increasing unmet needs for renal transplant, a clear understanding of determinants of posttransplant outcomes is essential. The importance of delayed graft function in deceased-donor kidney transplant is now part of conventional medical wisdom, due to the large amount of evidence focused on this aspect. However, the same is not true for living-donor kidney transplant, partly due to lack of evidence on this crucial clinical question and partly due to lack of awareness about this issue. The current review aims to highlight the importance of delayed graft function as a crucial determinant of outcomes in living-donor kidney transplant. An exhaustive search of online medical databases was performed with appropriate search criteria to collect evidence about delayed graft function after living-donor kidney transplant, with a special focus on studies from the Middle East. Data on incidence, impact, risk factors, and possible prevention modalities of delayed graft function in patients undergoing living-donor kidney transplant are presented. A key finding of this review is that contemporary incidence rates reported from the Middle East are comparatively higher than those reported from outside the region. Although in absolute terms the incidence is lower than deceaseddonor kidney transplant, the effects of delayed graft function on graft rejection and graft and patient survival are sufficiently large to warrant the formulation of specific treatment protocols. Key to formulating prevention and treatment strategies is identifying discrete risk factors for delayed graft function. Although this evidence is scant, an overview has been provided. Further studies examining different aspects of delayed graft function incidence after living-donor kidney transplant are urgently needed to address a so far little known clinical question.

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The Correlation of Renal Allograft Weight to Metabolic Index Ratios and Glomerular Filtration Rate Among Living-Unrelated Kidney Transplant Patients: A Cross-Sectional Study

Cited by 16 publications

References 11 publications

Small Kidneys for Large Recipients: Does Size Matter in Renal Transplantation?

Small Kidneys for Large Recipients: Does Size Matter in Renal Transplantation?

Donor-Recipient Gender and Size Mismatch Affects Graft Success after Kidney Transplantation

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