The correlation of ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia

Chansai, Siriyakorn; Yamsri, Supawadee; Fucharoen, Supan; Fucharoen, Goonnapa; Teawtrakul, Nattiya

doi:10.4084/mjhid.2022.052

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Another potential explanation is the impact of altered erythropoiesis on lipid metabolism. Alpha-thalassemia affects red blood cell production and can lead to ineffective erythropoiesis, where a higher number of immature red blood cells are produced ( 36 ). This altered erythropoiesis may disrupt normal lipid metabolism and result in lower levels of TG as observed in the coexistence of alpha-thalassemia in SCD.…”

Section: Discussionmentioning

confidence: 99%

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Cruz,

Valente,

Ferreira

et al. 2024

Braz J Med Biol Res

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Variations in lipid profile have been observed in sickle cell disease (SCD) and understanding their relationship with disease severity is crucial. This study aimed to investigate the association of polymorphisms of the CETP gene and laboratory markers of disease severity with lipid profile in a pediatric population with SCD. Biochemical and anthropometric analyses and CETP and alpha-thalassemia genotyping were performed. The study included 133 children and adolescents with sickle cell anemia (SCA) or hemoglobin SC disease (SCC), in steady-state. The SCA and no hydroxyurea (no HU) groups had higher values of ApoB, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) compared to the SCC and HU groups. However, there were no significant differences in ApoA1 and HDL-C levels between the groups based on genotype. Furthermore, the groups with altered levels of ApoA1, HDL-C, and the triglyceride/HDL ratio exhibited lower hemoglobin (Hb) levels and higher white blood cell counts. Hb level was associated to HDL-C levels. Analysis of CETP gene variants showed that the minor alleles of rs3764261 (C>A), rs247616 (C>T), and rs183130 (C>T), as well as the TTA haplotype, are explanatory variables for HDL-C levels. These findings suggested that dyslipidemia in SCD, specifically related to HDL-C levels, may be influenced by individual genetic background. Additionally, further investigation is needed to determine if clinical manifestations are impacted by CETP gene variants.

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Section: Discussionmentioning

confidence: 99%

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Cruz,

Valente,

Ferreira

et al. 2024

Braz J Med Biol Res

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“…There are few studies in the literature measuring CEC levels in β‐thalassemia patients [ 17 , 18 ]. In our study, we found that CEC levels in patients with βThal were significantly higher than the control group.…”

Section: Discussionmentioning

confidence: 99%

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Görgülügil,

Uğur Kurtoğlu,

Uğur

et al. 2024

Clinical Laboratory Analysis

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Background/ObjectivesCD71+ erythroid cells (CECs) are immature red blood cells (proerythroblasts, erythroblasts, and reticulocytes). CECs play an important role in the development of sepsis and cancer by causing immunosuppression. We examined the CEC levels in the peripheral blood of beta thalassemia (βThal) patients and investigated the relationship between CECs and the clinical status of the patients, especially splenectomy.MethodsSixty‐eight patients with βThal (46 splenectomized and 22 nonsplenectomized) and 15 healthy controls were included in this study. The hemogram parameters, ferritin, and CECs (flow cytometry method) were measured.ResultsIt was observed that the CEC level in the patient group was significantly higher than the control group (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy (p < 0.05). CEC levels were higher in patients with nontransfusion‐dependent βT (NTD‐βThal) than in patients with transfusion‐dependent βT (TD‐βThal) (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy in both TD‐βThal and NTD‐βThal groups (p < 0.05). There was a moderate‐negative correlation was detected between CECs and Hb levels (r = −0.467; p < 0.05).ConclusionsHigh CEC levels in βThal patients develop as a result of ineffective erythropoiesis. We think that keeping CEC levels under control is important for prognosis, especially in patients with splenectomy.

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The correlation of ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia

Cited by 2 publications

References 17 publications

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

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The correlation of ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia

Cited by 2 publications

References 17 publications

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease

Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

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Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia