The correlation of atherosclerosis and triglyceride glucose index: a secondary analysis of a national cross-sectional study of Japanese

Yang, Xingping; Gao, Zhao; Huang, Xuming; Zhang, Mingxing; Chen, Zhuoming

doi:10.1186/s12872-022-02685-8

Cited by 11 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, TyG was effective to screen steatosis, and was superior to other indicators for MAFLD [ 54 ]. Besides, the mean TyG (8.86 mmol/L) of participants in our study was higher than the threshold (TyG ≥ 8.5 mmol/L) proposed for identifying MAFLD among the general population in China [ 25 ], and was also higher than the mean level among the general population in Korea [ 55 ] and Japan [ 56 ]. The difference might be explained by the heterogeneity in metabolic status between the employed adults and the general population.…”

Section: Discussioncontrasting

confidence: 78%

Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults

Yang

Wang

et al. 2023

BMC Public Health

View full text Add to dashboard Cite

Objective Metabolic-associated fatty liver disease (MAFLD) is of concern in employed adults, while the crucial indicators in predicting MAFLD are understudied in this population. We aimed to investigate and compare the prediction performance of a set of indicators for MAFLD in employed adults. Methods A cross-sectional study recruiting 7968 employed adults was conducted in southwest China. MAFLD was assessed by abdominal ultrasonography and physical examination. Comprehensive indicators of demographics, anthropometric, lifestyle, psychological, and biochemical indicators were collected by questionnaire or physical examination. All indicators were evaluated for importance in predicting MAFLD by random forest. A prognostic model based on multivariate regression model was constructed to obtain a prognostic index. All indicators and prognostic index were compared to evaluate their prediction performance in predicting MAFLD by the receiver operating characteristic (ROC) curve, calibration plot, and Decision curve analysis (DCA). Results Triglyceride Glucose-Body Mass Index (TyG-BMI), BMI, TyG, triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C), and TG ranked the top five important indicators, and TyG-BMI performed the most accurate prediction of MAFLD according to the ROC curve, calibration plot and DCA. The area under the ROC curves (AUCs) of the five indicators were all over 0.7, with TyG-BMI (cut-off value: 218.284, sensitivity: 81.7%, specificity: 78.3%) suggesting the most sensitive and specific indicator. All five indicators showed higher prediction performance and net benefit than the prognostic model. Conclusion This epidemiological study firstly compared a set of indicators to evaluate their prediction performance in predicting MAFLD risk among employed adults. Intervention targeting powerful predictors can be helpful to reduce the MAFLD risk among employed adults.

show abstract

Section: Discussioncontrasting

confidence: 78%

Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults

Yang

Wang

et al. 2023

BMC Public Health

View full text Add to dashboard Cite

show abstract

“…2A). Relatively similar outcomes were achieved in 10 studies in which the TyG index was treated as a continuous variable [22,24–28,31–34] (RR: 1.46, 95% CI: 1.32–1.61, I 2 = 77%, P < .001; Fig. 2B).…”

Section: Resultssupporting

confidence: 60%

“…Lee 2018 [23] men 1.77 1.41-2.22 72 <.001 Lee 2018 [23] women 1.86 1.46-2.38 77 <.001 Li 2020 [24] 1.67 1.44-1.93 23 <.001 Su 2021 [27] 1.87 1.46-2.39 77 <.001 Wang 2021 [28] 1.92 1.50-2.46 75 <.001 Wu 2021 [29] 1.91 1.47-2.47 76 <.001 Zhao 2019 [30] 1.94 1.52-2.47 73 <.001 Wu 2020 [32] 1.92 1.49-2.46 76 <.001 Yang 2022 [33] 1.87 1.47-2.38 77 <.001 Ji 2022 [34] 1.86 1.49-2.33 74 <.001 CI = confidence interval, RR = risk ratio, TyG = triglyceride-glucose.…”

Section: Dataset Excluded Rr 95% CI I 2 % P For Effectmentioning

confidence: 99%

Association between the triglyceride-glucose index and arterial stiffness: A meta-analysis

et al. 2023

View full text Add to dashboard Cite

Background: Studies have shown a strong association between the triglyceride-glucose (TyG) index, a simple marker of insulin resistance, and various metabolic diseases. We performed a systematic review of the interaction between the TyG index and arterial stiffness.Methods: Relevant observational studies assessing the association between the TyG index and arterial stiffness were thoroughly searched in PubMed, Embase, and Scopus, and a manual search of the preprint server was conducted. A random-effects model was utilized to analyze the data. The risk of bias for the included studies was assessed using the Newcastle-Ottawa Scale. A pooled effect size estimate with a random-effects model was used for the meta-analysis.Results: Thirteen observational studies comprising 48,332 subjects were included. Of these, 2 were prospective cohort studies, and the remaining 11 were cross-sectional studies. According to the results of the analysis, the risk of developing high arterial stiffness was 1.85 times greater for those in the highest TyG index subgroup versus the lowest group (risk ratio [RR]: 1.85, 95% confidence interval: 1.54-2.33, I 2 = 70%, P < .001). Consistent results were observed when the index was analyzed as a continuous variable (RR: 1.46, 95% confidence interval: 1.32-1.61, I 2 = 77%, P < .001). A sensitivity analysis excluding each of the studies one by one yielded similar results (RRs for categorical variables: 1.67-1.94, P all <.001; RRs for continuous variables: 1.37-1.48, P all <.001). A subgroup analysis showed that different characteristics of the study subjects, such as type of study design, age, population, disease status, (including hypertension and diabetes), and pulse wave velocity measurement methods had no substantial effect on the results (P for subgroup analysis, all >0.05).Conclusions: A relatively high TyG index might be linked to an increased incidence of arterial stiffness.

show abstract

“…Table 1 presents the baseline characteristics of the included studies, which were published between 2017 and 2022, with a sample size ranging from 180 to 13,706 and a total of 87,307 participants. Among the included studies, 15 were from China[ 9 , 14 , 15 , 28 , 29 , 31 , 33 , 34 , 36 , 40 , 42 , 44 , 45 , 47 , 50 ], seven were conducted in Korea [ 27 , 30 , 34 , 35 , 37 – 39 ], three were from [ 42 , 48 , 49 ] Japan [ 41 , 47 , 49 ], and only one originated in non-Asia (United States) [ 43 ]. The mean age of participants ranged from 28.7 to 75 years, and the BMI ranged from 22.5 to 28.5 kg/m 2 .…”

Section: Resultsmentioning

confidence: 99%

“…2 A ) . When the TyG index was treated as a continuous variable [ 14 , 28 , 36 , 40 – 45 , 47 , 48 ], each unit of the TyG index increased the risk of arterial stiffness by 51% (OR = 1.51, 95% CI 1.35–1.69, I 2 = 82%, τ 2 = 0.03) (Fig. 2 B).…”

Section: Resultsmentioning

confidence: 99%

Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis

Liu

Ling

Xie

et al. 2023

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background The triglyceride and glucose (TyG) index has been linked to various cardiovascular diseases. However, it's still unclear whether the TyG index is associated with arterial stiffness and coronary artery calcification (CAC). Methods We conducted a systematic review and meta-analysis of relevant studies until September 2022 in the PubMed, Cochrane Library, and Embase databases. We used a random-effects model to calculate the pooled effect estimate and the robust error meta-regression method to summarize the exposure-effect relationship. Results Twenty-six observational studies involving 87,307 participants were included. In the category analysis, the TyG index was associated with the risk of arterial stiffness (odds ratio [OR]: 1.83; 95% CI 1.55–2.17, I2 = 68%) and CAC (OR: 1.66; 95% CI 1.51–1.82, I2 = 0). The per 1-unit increment in the TyG index was also associated with an increased risk of arterial stiffness (OR: 1.51, 95% CI 1.35–1.69, I2 = 82%) and CAC (OR: 1.73, 95% CI 1.36–2.20, I2 = 51%). Moreover, a higher TyG index was shown to be a risk factor for the progression of CAC (OR = 1.66, 95% CI 1.21–2.27, I2 = 0, in category analysis, OR = 1.47, 95% CI 1.29–1.68, I2 = 41% in continuity analysis). There was a positive nonlinear association between the TyG index and the risk of arterial stiffness (Pnonlinearity < 0.001). Conclusion An elevated TyG index is associated with an increased risk of arterial stiffness and CAC. Prospective studies are needed to assess causality. Graphical Abstract

show abstract

The correlation of atherosclerosis and triglyceride glucose index: a secondary analysis of a national cross-sectional study of Japanese

Cited by 11 publications

References 46 publications

Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults

Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults

Association between the triglyceride-glucose index and arterial stiffness: A meta-analysis

Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis

Contact Info

Product

Resources

About