The Correlation between Vitamin D and Polycystic Ovary Syndrome

Abstract

Background: A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in many other chronic diseases. Recent studies have suggested a relevance of vitamin D to reproductive physiology. Moreover, recent evidence is establishing to support the hypothesis that vitamin D status may contribute to the development of metabolic disturbances in PCOS. Aim of the Study: To investigate the relationship between Vitamin D level and polymorphisms related to metabolic disturbances particularly Insulin resistance in women with PCOS. Methods: A review of the scientific literature (PubMed Search 1960 to 2017) Pubmed, Embase and CENTRAL were searched to identify randomized controlled trials that investigated The Correlation between Depression and Folate Deficiency as the primary outcome. Identification of papers and data extraction were performed by two independent researchers. We searched for relevant trials in the Cochrane Library, MEDLINE (from 1960), Embase (from 1960), and ongoing trial databases; all searches current to October 2017. Results: Eight studies were included enrolling 1225 women; 779 patients with depression and 446 control subjects. Univariate regression analyses of the weighted means indicated a significant correlation between vitamin D and IR predictability in both PCOS and control women. However, the significance was neutralized after factoring BMI in PCOS women. Conclusion: There is a growing body of evidence suggesting an inverse association between vitamin D status and metabolic disturbances in PCOS in the current literature yet heterogeneity of the conducted studies made it difficult to come out with a solid conclusion. Nevertheless, normalization of vitamin D levels is recommended generally and especially for PCOS patients.

Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

“…In this issue, Hahn et al proposed that low vitamin D levels might be a primeval factor in the initiation and progression of PCOS, and that dietary abundance of vitamin D could help to restore normal menses in female with this syndrome (21). Several studies also assumed that vitamin D deficiency might be a causal factor in the pathogenesis of IR and the metabolic disturbance found in PCOS (22,23). In addition, recent studies which concluded that low vitamin D levels may aggravate the symptoms of PCOS, including IR, ovulatory dysfunction, irregular menses, impaired fertility, and hydperandrogenism (24,25).…”