The Correlation Between Urinary 8-Iso-Prostaglandin F2α and Hydrogen Peroxide Toward Renal Function in T2DM Patients Consuming Sulfonylurea and Combination of Metformin-Sulfonylurea

Sauriasari, Rani; Wulandari, Fitri; Nurifahmi, Rahmaningtyas; Sekar, Andisyah Putri; Susilo, Veronika Yulianti

doi:10.2174/1573399812666161214141716

Cited by 3 publications

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“…This is consistent with our observation that the associations were stronger when we considered baseline oxidant stress in relation to longitudinal outcomes compared with the analysis of longitudinal oxidant stress measures with longitudinal outcomes. Cross-sectional studies that have measured urinary F 2 -isoprostanes have reported positive associations with eGFR [46][47][48] , and one also found a negative association with albuminuria. Our results provide evidence of this same phenomenon even in a longitudinal setting, and is supported by our consistent observation that urinary oxidant stress biomarkers were associated with a reduced hazard of RRT.…”

Section: Discussionmentioning

confidence: 99%

Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study

Jacobson

Liu

et al. 2020

Sci Rep

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it is hypothesized that chronic kidney disease (cKD) induces oxidant stress which contributes to the decline in kidney function. However, few studies have incorporated longitudinal designs and no studies have investigated this association among children. Using data from the chronic Kidney Disease in children (cKiD) study, we examined longitudinal associations between urinary biomarkers of oxidant stress, 8-OH deoxyguanosine (8-OHdG) and F2-isoprostane, and measures of renal function and blood pressure among children with CKD. Baseline levels of 8-OHdG were positively associated with estimated glomerular filtration rate (eGFR) over time and a log-unit increase in baseline 8-OHdG predicted a 5.68 ml/min/1.73 m 2 increase in eGFR (95% Confidence Interval (CI): 3.75, 7.61). This association was attenuated when longitudinal measures of 8-OHdG were analyzed in relation to longitudinal eGFR (per log-unit increase in 8-OHdG, β = 0.81, 95% CI: 0.22, 1.39). Baseline 8-OHdG concentrations were also associated with decreased proteinuria over time, as measured by urinary protein:creatinine ratio. In addition, F2-isoprostane concentrations were associated with increases in eGFR, but only when baseline levels (vs. longitudinal levels) were considered in relation to longitudinal eGFR. There were no significant associations between either 8-OHdG or F2-isoprostane and blood pressure over time. Urinary measures of oxidant stress are not associated with worsening GFR over time. Our findings suggest that excretion of these biomarkers may be influenced by changes in glomerular and tubular function in varying patterns, which would limit their value in evaluating the impact of oxidant stress on cKD progression in children.Chronic kidney disease (CKD) is a progressive condition that ultimately leads to loss of kidney function and a need for renal replacement therapy (RRT), either dialysis or transplant 1 . CKD is common in the US, affecting 11% of adults 2,3 , and is projected to increase over time 4 . Although substantially less common in children, it is associated with substantial adverse sequelae specific to this age group, such as growth impairment, cognitive deficits, and cardiovascular complications 5,6 .Several factors have been shown to affect the rate of decline in kidney function among those with CKD 7 . Mechanistically, it has been widely hypothesized that oxidant stress accelerates kidney function decline 8-10 . This can arise within the glomeruli or the tubulointerstitium, in the later compartment secondary to increased tubular workload and oxygen consumption 11,12 . An imbalance in the production of reactive oxygen species and antioxidant defenses disturbs cell signaling and promotes injury to the kidneys, limits cellular repair mechanisms, and accelerates functional decline. In several cross-sectional studies, plasma levels of oxidant stress have been found to be associated with advanced stages of CKD [13][14][15] . Further evidence in support of this relationship is limited by a lack of longitudinal studies examining both...

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Section: Discussionmentioning

confidence: 99%

Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study

Jacobson

Liu

et al. 2020

Sci Rep

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“…Small lipids in the form of eicosanoids have the capacity to be either proinflammatory or anti‐inflammatory and pro‐resolution (Dennis & Norris ) and have been linked to peroxidation of membrane lipids (Sauriasari et al. ; Van't Erve et al. ).…”

Section: Future Studies and Challengesmentioning

confidence: 99%

“…More studies should be conducted on mediators of oxidative stress such as lipids. Small lipids in the form of eicosanoids have the capacity to be either proinflammatory or anti-inflammatory and pro-resolution (Dennis & Norris 2015) and have been linked to peroxidation of membrane lipids (Sauriasari et al 2016;Van't Erve et al 2016). For example, in dry eye, the small lipid prostaglandin E2 (PGE2) has been found to increase and prostaglandin D2 (PGD2) to decrease in the tears (Shim et al 2012).…”

Section: Future Studies and Challengesmentioning

confidence: 99%

Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

221

162

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Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease. The biomarkers used to indicate oxidative damage in ocular surface tissues include 8-hydroxy-2 deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE) and malondialdehyde (MDD). Antioxidative defences in the ocular surface occur in the form of tear proteins such as lactoferrin and S100A proteins, and enzymes such as superoxide dismutase (SOD), peroxidase, catalase and mitochondrial oxidative enzymes. An imbalance between the level of reactive oxygen species (ROS) and the action of protective enzymes will lead to oxidative damage, and possibly inflammation. A small number of interventional studies suggest that oxidative stress may be directly targeted in topical therapy of dry eye treatment. For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful. Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis. With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.

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“…This result was in line with the study that has been conducted previously, in which the level of urinary 8-iso-Prostaglandin F2α in metformin-sulfonylurea group was lower than sulfonylurea group. 11 It is known that metformin produced significant effect on the malondialdehyde, a lipid peroxidation product, whereas sulfonylurea was not. 12 Thus, metformin could be more effective in reducing the oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

“…Glomerular filtration rate is known to have a positive correlation with levels of 8-iso-Prostaglandin F2α. 6,11 The linear regression analysis results in albuminuric subjects (n=55) indicate HbA1c and the use of a combination of metformin-sulfonylurea were the most predictive factors for increased UACR, after controlled by age, gender, IMT, systolic blood pressure, 8-iso-Prostaglandin F2α, smoking habit and exercise habit (Table 4). It is reported that the use of sulfonylureas compared with metformin for initial treatment of diabetes were associated with an increased hazard of cardiovascular disease events or death, through UACR as one of the markers.…”

Section: Bivariate Correlationmentioning

confidence: 99%

Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients

Sauriasari¹,

Andriany

Sekar

et al. 2017

JYP

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Background: Even though oxidative stress is intensively studied for its role in diabetic nephropathy, the effectiveness of first-line medication on diabetes in preventing oxidative stress and diabetic nephropathy is still unknown. This study aimed to analyze 8-iso-Prostaglandin F2α, UACR, and their correlation on 114 type 2 diabetes mellitus patients who consumed metformin and the combination of metformin-sulfonylurea. Material and Method: Urinary 8-iso-Prostaglandin F2α was measured by ELISA and urinary albumin was measured by Bromocresol Green Albumin assay. Results: The results showed that HbA1c (p=0.038) and 8-iso-Prostaglandin F2α level higher in the combination group than in metformin group, but not for UACR (p=0.838). However, subgroup analysis on albuminuric patients (UACR>30 mg/g, n=55) showed no different in HbA1c and 8-isoProstaglandin F2α level between the medication groups. Linear regression analysis showed HbA1c (β=0.402, p=0.002) and the combination of metformin-sulfonylurea (β=0.364, p=0.004) were the most predictive factors for increased UACR after controlled by age, gender, IMT, systolic

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The Correlation Between Urinary 8-Iso-Prostaglandin F2α and Hydrogen Peroxide Toward Renal Function in T2DM Patients Consuming Sulfonylurea and Combination of Metformin-Sulfonylurea

Abstract: The two treatments did not have any significant differences in antioxidant activity. However, an increase of urinary 8-iso-prostaglandin F2. and hydrogen peroxide which correlates with eGFR in the total sample may play a significant role in the pathophysiology of diabetic nephropathy.

Cited by 3 publications

References 0 publications

Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study

Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study

Dry eye disease and oxidative stress

Comparison of Antioxidative Effect of Metformin and Combination of Metformin-Sulfonylurea in Type 2 Diabetes Mellitus Patients

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