The correlation between transcription factor 7-like 2 gene polymorphisms and susceptibility of gestational diabetes mellitus in the population of central China: A case–control study

Abstract

ObjectiveTo investigate the correlation between transcription factor 7-like 2 (TCF7L2) gene polymorphisms and gestational diabetes mellitus (GDM) risk in the central Chinese population.MethodsThis case–control study examined the association of seven TCF7L2 gene single-nucleotide polymorphisms (SNPs) (rs11196218, rs4506565, rs7895340, rs7901695, rs11196205, rs12243326, and rs290487) with GDM risk in the central Chinese population (843 GDM and 877 controls). The clinical information and blood samples were collected by trained interviewers and nurses. Genotyping of SNPs was conducted on the Sequenom MassARRAY platform. Statistical analyses including t-test, ANOVA, chi-square test, Fisher’s exact test, and logistic regression were performed.ResultsDifferences in age, pre-pregnant body mass index (BMI), and family history of type 2 diabetes mellitus (T2DM) between the case and control groups were significant (p < 0.05). Compared with the wild-type genotype, pregnant women with genotypes of rs4506565-AT (OR = 1.89, 95%CI: 1.18–3.02), rs7895340 GA (OR = 1.93, 95%CI: 1.06–3.54), rs7901695-TC (OR = 1.79, 95%CI: 1.11–2.88), and rs11196205-GC (OR = 2.15, 95%CI: 1.16–3.98) had a significantly higher risk of GDM, adjusted by age, pre-pregnant BMI, and family history of T2DM. Functional annotation showed that all these four SNPs fell in the functional elements of human pancreatic islets. Further cumulative effects analysis concluded that when participants carried all these four risk genotypes, the risk of GDM was 3.51 times (OR = 3.51, 95%CI: 1.38–8.90) than that of those without any risk genotypes.ConclusionsThe findings of this study suggested that rs4506565, rs7895340, rs7901695, and rs11196205 were the genetic susceptibility SNPs of GDM in the central Chinese population. Further studies are needed to validate our findings and clarify the underlying mechanisms.

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

“…Several TCF7L2 SNPs have been reported to be associated with a high risk of developing GDM in various populations [7][8][9][10]. Notably, all SNPs are in intronic regions, as shown in Table 1, suggesting the regulatory function of the SNPs in cell-context specificity.…”

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

“…Numerous studies have explored the relationship between genetic markers and the likelihood of developing GDM, shedding light on the underlying genetic factors contributing to this condition (19). (20,21) have conducted research in this area. For instance, these studies have discovered that specific gene variants, such as TCF7L2 and KCNJ11, are associated with a higher risk of GDM (20)(21)(22).…”

“…(20,21) have conducted research in this area. For instance, these studies have discovered that specific gene variants, such as TCF7L2 and KCNJ11, are associated with a higher risk of GDM (20)(21)(22). These results pave the way for the development of personalized risk prediction models and provide valuable insights into the genetic basis of GDM.…”