The Correlation between Severity of Overactive Bladder Symptoms with Female Sexual Dysfunction and Sexual Satisfaction of Partners

Wang, Yangyun; Shi, Chaoliang; Wang, Yang; Wei, Jiao; Wang, Xilong; Zhang, Jun; Shi, Guowei; Wu, Denglong

doi:10.1159/000508764

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…The study results should be interpreted with the following limitations in mind. Presently, the impact of age and BMI on urine levels of choline and acetylcholine, both of which are associated with OAB, is not well understood [ 33 , 34 ]. Though we accounted for differences in age with matching,, in this analysis there were significant differences in BMI between controls and patients with UUI and responders and non-responders.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship of cholinergic metabolites in urine and urgency urinary incontinence

et al. 2021

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Introduction and hypothesis To investigate differences in urine cholinergic metabolites in women with urinary urgency incontinence (UUI) and responders (R) and non-responders (NR) to anti-cholinergic medications (AC). Methods Patients with UUI and age-matched controls were evaluated pre- and post-treatment using OABSS, UDI-6 and IIQ-7. Controls were defined as having a cumulative OABSS of zero. Patients with UUI were treated with AC and followed for 12 weeks. Responders were those with a > 50% decrease in the total OABSS score. Urine samples were collected from all participants for evaluation. Metabolite detection was accomplished using commercial assay kits. Wilcoxon-rank sum test and Fisher’s exact test were used to express differences between groups. Spearman’s rho correlation coefficient was used to determine the relationship between acetylcholine (Ach), choline (Ch), acetylcholinesterase (AchE) and questionnaire scores. Results We recruited 39 with UUI and 33 controls. We found concentrations of Ch [29.0 (IQR: 24.2–42.5) μmol vs. 15.2 (IQR: 7.5–24.1) μmol] and Ach [65.8 (IQR: 30.4–101.8) nmol and 33.1 (IQR: 11.9–43.8) nmol] were higher in the UUI group compared to controls ( p = 0.003 and p < 0.001, respectively] and no differences in AchE concentrations. In the UUI group, 43.6% responded to AC after 12 weeks of therapy. There were no differences in Ch or AchE levels between R and NR; Ach levels were higher in the R group [82.1 nmol (IQR: 54.8–118.1) vs. 50.3 nmol (IQR: 29.9–68.2), p = 0.007]. Ch and Ach were positively associated with pre-treatment OABSS parameters. Conclusions Urine Ach is higher in responders to anti-cholinergic therapy, and urine cholinergic metabolites were higher in the UUI patients compared to controls.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship of cholinergic metabolites in urine and urgency urinary incontinence

et al. 2021

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“…Unfortunately, most women, especially those who already experience OAB symptoms, seldom express concerns about the decline in sexual function. It has been shown that patients with OAB score lower on the Female Sexual Function Index and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire [ 108 ], indicating that their sexual function is impaired. Traditional pelvic floor physical therapy, anticholinergic medications, and onabotulinumtoxinA (commonly known as Botox) intravesical injections are the first line of treatment for OAB.…”

Section: Pelvic Floor Disordersmentioning

confidence: 99%

Female Sexual Dysfunctions and Urogynecological Complaints: A Narrative Review

et al. 2022

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Female sexual dysfunctions represent a real widespread problem, usually faced from a psychological point of view; however, millions of women worldwide are impacted by pelvic floor dysfunction, personal shame and social taboos, however, continue to inhibit free conversation on the subject. Women’s quality of life is considerably improved by screening, diagnosing, and controlling urogenital and sexual issues. This review aims to provide a critical perspective of urogenital conditions and common disturbances in female sexual function associated with these issues. It also includes a discussion of postpartum pelvic dysfunction.

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“…Possibly, the decrease in the urgency UI episodes with the treatment could also improve these more global aspects of the sexual life. In relation to this, Wang et al [32] performed a study including 323 women with overactive bladder and demonstrated the effect of the severity of its symptoms on the rate of female sexual dysfunction and partners' sexual satisfaction. When the different domains of the overactive bladder were analyzed, the urgency symptoms showed a significant effect on the female sexual function, as more severity of urgency UI has been associated with a higher rate of female sexual dysfunction [32].…”

Section: Urgency Urinary Incontinence Treatment and Sexualitymentioning

confidence: 99%

“…When the different domains of the overactive bladder were analyzed, the urgency symptoms showed a significant effect on the female sexual function, as more severity of urgency UI has been associated with a higher rate of female sexual dysfunction [32]. In this way, UI was closely associated with partners' sexual satisfaction [32]. Serati et al [17] reported that the form of coital UI during orgasm is curable by antimuscarinic treatment in about 60% of cases when associated with detrusor overactivity.…”

Section: Urgency Urinary Incontinence Treatment and Sexualitymentioning

confidence: 99%

Impact of Urinary Incontinence on Women’s Sexuality

Sancho¹,

Ribera-Torres²,

Castelo-Branco³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Objective: Globally, the prevalence of urinary incontinence (UI) in women is estimated to be in the range of 25% to 45%. Different types of UI exist, being the most frequent ones stress UI, urgency UI and mixed UI. Being affected by UI is associated with a higher risk of sexual inactivity, regardless of its type. Mechanism: It is estimated that 5-38% patients with UI are sexually inactive due to UI, whereas 25-38% sexually active women would restrict their sexual activity due to UI. The prevalence of sexual dysfunction within sexually active women with UI is 23-56%. Findings in brief: In patients with UI, the most frequent sexual dysfunctions are dyspareunia (44%), female sexual interest/arousal disorder (34%) and orgasmic disorder (11%). Therefore, UI has a negative impact on the sexual function of sexually active women with UI. Coital incontinence is defined as the complaint of involuntary loss of urine during or after intercourse. UI with penetration represents any complaint of involuntary loss of urine with vaginal stimulation (either with a sexual toy, manually or with penetration). Orgasmic UI refers to any complaint of involuntary loss of urine occurring at orgasm, regardless of the sexual behaviour that has triggered it. Due to the high prevalence of coital UI (50-60%) in the female population and its strongly negative impact on women's sexuality, patients should be specifically asked for coital UI in the gynecologic visits. Conclusions: UI affects between one in four and one in two women and had a negative impact on quality of life. Not only UI has an impact on female sexuality, but also different treatments which are offered to treat it can play a role. The reduction of sexual problems with pelvic floor muscle training in women with stress UI has been proved, being the rate of sexual activity doubled. A significant improvement of the overactive bladder associated to urgency UI and female sexual function has been described after the pharmacological treatment or botulinum toxin. Finally, significant improvement of the sexual function has also been found after midurethral slings for stress UI, as well as for coital UI.

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The Correlation between Severity of Overactive Bladder Symptoms with Female Sexual Dysfunction and Sexual Satisfaction of Partners

Cited by 8 publications

References 33 publications

Evaluation of the relationship of cholinergic metabolites in urine and urgency urinary incontinence

Evaluation of the relationship of cholinergic metabolites in urine and urgency urinary incontinence

Female Sexual Dysfunctions and Urogynecological Complaints: A Narrative Review

Impact of Urinary Incontinence on Women’s Sexuality

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