The Correlation Between Serum Vitamin D Level and Total Antioxidant Capacity in diabetic and Non-diabetic Subjects in Iran

Zare-Mirzaie, Ali; Kazeminezhad, Behrang; Ghouchani, Mona Akbari

doi:10.30699/ijp.13.2.212

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…[37] Similarly Aoucheri et al, Zare-Mirzaie et al, and Dhas et al, reported relatively lower values. [38,39,40] Sheth et al reported values of 8.36% ± 1.79%, which were comparable to those of the current study. [41] Previous study stated that a FBS of patients was 175.5 ± 30.08 (mg/dL) which is significantly higher than control group their mean 74.17 ± 13.76 (mg/dL) (P< 0.01).…”

Section: Table;5supporting

confidence: 91%

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Singh,

Kaur,

Verma

2023

J. Adv. Zool.

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Type 2 diabetes mellitus (T2DM) has a heavy disease burden and is one of the leading causes of death worldwide. It is considered to be evolving from a complex and multifactorial metabolic disorder to an inflammatory condition. The strong link between hyperglycemia and oxidative stress has long been established. Oxidative stress leads to the generation of inflammatory mediators and reactive oxygen species, which results in an inflammatory state, which plays a key role in the pathogenesis of diabetic complications. We aimed to correlate the levels of Glycated Hemoglobin with Oxidative Stress.This cross-sectional study included 200 subjects, 100 were type 2 diabetic patients and 100 were healthy non-diabetic individuals. The data were analyzed using a t test. The results showed that as the Glycated Hb increased, the levels of FBS, MDA increased and Serum SOD, Glutathione and Catalase levels decreased. The results showed a positive correlation between HbA1c and fasting blood glucose (r = 0.417, p= 0.000) and MDA (r= 0.340, p=0.000). Whereas negative correlation was observed between HbA1c and other antioxidant parameters, SOD (r= 0.025, p=0.803) Catalase (r= 0.096, p= 0.342), Glutathione (r= -0.164, p= 0.103). It is hereby concluded for the present study that when glycated Hb increases the natural antioxidants that is SOD, catalase and glutathione decrease to combact the increased formation of ROS. Serum MDA, a marker of lipid peroxidation, increased with increased glycated Hb, and shows a positive correlation, indicating that lipid peroxidation increased, when glycation of Hb increased, thus depicting an increased chance of macrovascular complication in type 2 diabetics.

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Section: Table;5supporting

confidence: 91%

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Singh,

Kaur,

Verma

2023

J. Adv. Zool.

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“…Our study showed that people with high BMI and severe VIT D3 de ciency have higher HSCRP than other group when adjusted with age, in people younger than 60 year old; decrease in VITD3 level accompanied by high HSCRP whereas in people older than 60 year, this relation is reverse. Data from latter studies (17,18,19) are very con icting, This nding may be due to some other interfering factor such as in ammatory markers. Difference between results of our study and others may be due to different study population.…”

Section: Discussionmentioning

confidence: 95%

Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital

Zare-Mirzaie¹,

Mehdizadeh²,

Babaheidarian³

2020

Preprint

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Background: In diabetic patients high HbA1c is associated with high level of HSCRP and VITD3 deficiency could result in diabetes and high HbA1c level. The aim of this study was to determine the relation of HbA1c, HSCRP and vitamin D3 in healthy individuals who referred to Rasool Akram Hospital. Methods: In this cross sectional study, individuals who referred to our center between 2018 and 2019 for the measurement of HbA1c were classified to three groups based on the level of the HbA1c: <5, 5-5.6 and 5.7≤. Then the Serum level of HSCRP and vitamin D3 were measured and compared between these three groups.Results: In this study, 90 healthy individuals were studied. In subjects with BMI below 25, no significant difference in HSCRP level was seen in group with low and normal HbA1c, but group with high HbA1c has non-significant higher level of HSCRP rather than group with normal HbA1c. In subject with BMI higher than 25, group with high HbA1c and low HbA1c had non-significant higher level of HSCRP than group with normal HbA1c and in the subjects, no significance difference at serum level of vitamin D3 level has been identified between HbA1c groups. Conclusion: As immunomedulatory role of VitD3 is shown in many studies and low VitD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VitD3 could be a better overview on vitD3 effect on glucose metabolism

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“…In AMI, the serum level of TOS is correlated with the intensity and complexity of coronary artery disease [59]. It was suggested that TAC may represent an indicator of the protective effects of antioxidant agents, and it is used as a new biomarker for the prevention, diagnosis, and prognosis of DM and several other diseases [60]. TAC was reported to be low in patients with AMI; therefore, the antioxidant therapy may have beneficial effects in the prevention of coronary artery disease [61] Thiols are an important antioxidant system since they are able to mediate redox-signaling processes as a response to oxidative stress, playing a significant role in mitigating the lipid peroxidative effects of ROS, along with other antioxidants in the body [62,63].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats

Boarescu

Bocşan

et al. 2019

Antioxidants

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We have investigated the cardio-protective effects of pretreatment with curcumin nanoparticles (CUN) compared to conventional curcumin (CUS) on the changes in oxidative stress parameters and inflammatory cytokine levels during induced acute myocardial infarction (AMI) in rats with diabetes mellitus (DM). DM was induced with streptozotocin, and AMI with isoproterenol. Eight groups of seven Wister Bratislava rats were included in the study. The N-C was the normal control group, AMI-C was the group with AMI, DM-C was the group with DM, and DM-AMI-C was the group with DM and AMI. All four groups received saline solution orally during the whole experiment. S-DM-CUS-AMI and S-DM-CUN-AMI groups received saline for seven days prior to DM induction and continued with CUS (200 mg/kg bw, bw = body weight) for S-DM-CUS-AMI and CUN for S-DM-CUN-AMI (200 mg/kg bw) for 15 days before AMI induction. The CUS-DM-CUS-AMI group received CUS (200 mg/kg bw), while the CUN-DM-CUN-AMI received CUN (200 mg/kg bw) for seven days prior to DM induction, and both groups continued with administration in the same doses for 15 days before AMI induction. CUS and CUN prevented elevation of creatine kinase, creatine kinase-MB, lactate dehydrogenase in all groups, with better results in the CUN (S-DM-CUN-AMI and CUN-DM-CUN-AMI groups). CUS and CUN significantly reduced serum levels of oxidative stress markers (malondialdehyde, the indirect assessment of nitric oxide synthesis, and total oxidative status) and enhanced antioxidative markers (total antioxidative capacity and thiols, up to 2.5 times). All groups that received CUS or CUN showed significantly lower serum levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1β. The best antioxidative and anti-inflammatory effects were obtained for the group that received CUN before DM induction (CUN-DM-CUN-AMI group). Pretreatment with CUN proved higher cardio-protective effects exerting an important antioxidative and anti-inflammatory impact in the case of AMI in DM.

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The Correlation Between Serum Vitamin D Level and Total Antioxidant Capacity in diabetic and Non-diabetic Subjects in Iran

Cited by 11 publications

References 22 publications

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital

Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats

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