The correlation between serum total bilirubin and outcomes in patients with different subtypes of coronary artery disease

Huang, Fang‐Yang; Peng, Yong; Huang, Bao‐Tao; Yang, Yong; Pu, Xiaobo; Chen, Shijian; Gui, Yi‐Yue; Xia, Tianli; Chen, Fei; Liu, Rui-Shuang; Zhu, Ye; Chen, Mao

doi:10.1016/j.cca.2016.12.020

Cited by 30 publications

(36 citation statements)

References 25 publications

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“…[9–11] However, the use of serum total bilirubin level for predicting the MACEs and long-term mortality is conflicting. [12,13] Furthermore, the magnitude of the prognostic value of total bilirubin varied considerably across studies.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of total bilirubin in patients with acute myocardial infarction

Shen

Zeng²,

Wu³

et al. 2019

Medicine

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Section: Introductionmentioning

confidence: 99%

Prognostic value of total bilirubin in patients with acute myocardial infarction

Shen

Zeng²,

Wu³

et al. 2019

Medicine

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“…TB reduces the oxidation of low-density lipoprotein, which is involved in the pathogenesis of atherosclerosis TA B L E 2 ORs and 95% CI of cross-sectional association of total bilirubin with QT interval (Holvoet, Stassen, Van Cleemput, Collen, & Vanhaecke, 1998). It has been suggested that the prognostic significance of TB is different in stable CAD and acute myocardial infarction (AMI) (Huang et al, 2017). For stable CAD, elevated TB levels are associated with better prognosis through reduction of cardiac reperfusion injury and improvement of postischemic cardiac function (Bakrania et al, 2017;Clark et al, 2000), while in AMI patients, elevated TB levels correlated with high burden thrombus (Hamur et al, 2016), coronary atherosclerosis (Sahin et al, 2013), and angiographic no-flow (Celik et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Relation of total bilirubin and QT interval prolongation (from the Third National Health and Nutrition Examination Survey)

Majeed

Ahmad

Ahsan

et al. 2019

Noninvasive Electrocardiol

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Objective The association of bilirubin with cardiovascular disease (CVD) is controversial. We sought to explore the association of total bilirubin (TB) levels with QT interval in a multiracial cohort. Methods A total of 6,627 participants (59.0 ± 13.3 years; 52.6% women, 49.7% Non‐Hispanic Whites) without CVD from the Third National Health and Nutrition Examination Survey were included in this analysis. QT was automatically measured from digital 12‐lead electrocardiogram in a central reading center. A multivariable logistic regression model was used to examine the cross‐sectional association between tertiles of TB and prolonged QT interval (≥450 ms in men and ≥460 ms in women). Results The prevalence of prolonged QT was higher among those with higher levels of TB (prolonged QT prevalence was 4.7%, 6.8%, and 7.0% across TB lower (0–0.4 mg/dl), middle (0.5–1.6 mg/dl), and higher (0.70–4.30 mg/dl) tertiles, respectively). In a model adjusted for potential confounders, participants within the highest TB tertile had significantly greater odds of the prolonged QT interval (Odds ratios [95% confidence interval] 1.53 [1.16–2.02]) compared to those with bilirubin levels in the first tertile. Each 0.29 mg/dl increase in TB levels was associated with a 12% (p‐value <.0001) increase in the prevalence of prolonged QT interval. This association was stronger in men than in women (interaction p‐value = .04). Conclusion Elevated bilirubin levels are associated with a prolonged QT interval. This finding extends our current knowledge on the relationship between serum bilirubin and CVD by demonstrating a link between higher TB and abnormal cardiac repolarization.

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“…Accurate identification of liver abnormalities cannot only reflect nonhepatic diseases, and influence diagnostic as well as therapeutic processes, but also indicate the infarct size and thrombus burden, and enable the prediction of prognosis and mortality in AMI patients and in HF patients. [ 21 – 26 ] Prior studies had also suggested that elevations in the CK-MB and troponin I levels were widely accepted as indicators of myocardial necrosis and as risk factors for the development of a fulminant course, and were useful in the diagnosis, risk stratification, guiding treatments, and provide prognostic information in patients with AMI. [ 12 , 13 , 27 ] Consistent with these findings, AMI patients presenting with HFpEF in our study had higher levels of inflammatory indicators (WBC counts, neutrophils counts, and Hs-CRP), elevated level of blood glucose, liver biomarkers (TB, ALT, and AST), and myocardial necrosis indicators (CK-MB, troponin I) than non-HF patients.…”

Section: Discussionmentioning

confidence: 99%

Predictors and prognosis for incident in-hospital heart failure in patients with preserved ejection fraction after first acute myocardial infarction

Liu²,

Xu³

et al. 2018

Medicine

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Patients with acute myocardial infarction (AMI) complicated by heart failure with preserved ejection fraction (HFpEF) are likely to have more adverse cardiovascular events and higher mortality. The purpose of this study was to examine the predictors and outcomes in AMI patients complicated by HFpEF.We examined the demographics, clinical data, and clinical outcomes in 405 consecutive subjects who firstly presented with AMI after undergoing emergency percutaneous coronary intervention from January 2013 to June 2016.Three hundred twenty patients and eighty-five patients were classified into the nonheart failure (non-HF) group and HFpEF group, respectively. Patients with HFpEF had higher prevalence of prior hypertension, had higher levels of biomarkers, and had a larger left atrial diameter with a nondilated left ventricle were more likely to develop multivessel disease-vessels and had infarction-related artery located in left anterior descending artery than patients without HF. Moreover, patients with HFpEF had a higher probability of developing the in-hospital incident cardiovascular complications and death than non-HF patients.Two routine biomarkers, levels of hypersensitive C-reactive protein and N-terminal-pro brain natriuretic peptide, and number of diseased-vessels were independent predictors for in-hospital HFpEF incidence in AMI patients with preserved LVEF. AMI patients with HFpEF had a higher probability of in-hospital cardiovascular outcomes and mortality.

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The correlation between serum total bilirubin and outcomes in patients with different subtypes of coronary artery disease

Cited by 30 publications

References 25 publications

Prognostic value of total bilirubin in patients with acute myocardial infarction

Prognostic value of total bilirubin in patients with acute myocardial infarction

Relation of total bilirubin and QT interval prolongation (from the Third National Health and Nutrition Examination Survey)

Predictors and prognosis for incident in-hospital heart failure in patients with preserved ejection fraction after first acute myocardial infarction

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