The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Shu, Juntao; Tan, Anjun; Li, Yan; Huang, Hong; Yang, Jingjing

doi:10.1186/s12891-022-05438-y

Cited by 24 publications

(16 citation statements)

References 27 publications

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“…These osteoblasts proliferate in a feedback manner and synthesize a large amount of bone alkaline phosphatase (BALP), significantly increasing serum ALP levels. [20] Our research, based on a nationally representative sample, is highly relevant to the U.S. population. Additionally, the large sample size enabled subgroup analysis, reporting correlations between serum levels of ALP and pelvic BMD across sex, age, and racial/ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

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The correlation between serum levels of alkaline phosphatase and bone mineral density in adults aged 20 to 59 years

Cheng

Zhao

2023

Medicine

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Serum alkaline phosphatase (ALP) plays an important role in bone metabolism. However, the association between serum ALP and bone mineral density (BMD) remains inconclusive. Therefore, this study aimed to explore the relationship between serum ALP levels and pelvic BMD in young adults. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey conducted from 2011 to 2016. Serum ALP levels and pelvic BMD were analyzed as independent and dependent variables, respectively. Weighted multivariate linear regression models and stratified analysis by age, sex, and race/ethnicity were applied after controlling for confounding factors to assess the relationship between serum ALP and pelvic BMD. Smooth curve fitting and threshold effect analysis were used to describe the nonlinear relationship between the 2 variables. A total of 7796 participants (4063 males and 3733 females) aged 20 to 59 years were included in this study. When serum ALP was represented as a continuous variable and fully adjusted in the regression model, ALP was significantly negatively correlated with pelvic BMD (β = −0.0008, 95% confidence interval: −0.0010 to −0.0006, P < .000001); this significant negative correlation persisted when ALP was transformed into a categorical variable, and was consistent in subgroup analyses. Additionally, smooth curve fitting and threshold effect analysis showed a persistent negative correlation between serum ALP and pelvic BMD, with a saturation effect at 97 U/L. Our results revealed a negative correlation between serum ALP levels and pelvic BMD in young adults. Monitoring serum ALP levels could help in the early detection of risks for bone metabolic disorders such as osteoporosis.

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Section: Discussionmentioning

confidence: 99%

“…These osteoblasts proliferate in a feedback manner and synthesize a large amount of bone alkaline phosphatase (BALP), significantly increasing serum ALP levels. [20]…”

Section: Discussionmentioning

confidence: 99%

The correlation between serum levels of alkaline phosphatase and bone mineral density in adults aged 20 to 59 years

Cheng

Zhao

2023

Medicine

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“…According to research, extracellular pyrophosphate, which is an inhibitor of mineral formation, and inorganic phosphate local rates are both increased by ALP, which promotes mineralization (61). Total alkaline phosphatase levels are actually shown to be a measure of increased osteoblastic activity and bone conversion status (62). According to a study by Takeda et al, four weeks of lutein treatment significantly increased the mass of the femoral bones, particularly the cortical bone.…”

Section: Discussionmentioning

confidence: 99%

Safety Assessment of Lutein and Zeaxanthin Supplementation and Its Effects on Blood Glucose Levels, Kidney Functions, Liver Functions and Bone Health - A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Anzar,

Joseph,

Sundaram

et al. 2023

Preprint

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ObjectiveHbA1c, a major marker for the sugar levels in the blood, is the litmus test for people who are on the verge of entering the diabetic zone and for those who are already affected by this disease. Oral hypoglycemic agents are the fine line of treatment in such cases. Nutraceutical and herbal supplements can be utilized as a prophylactic to keep such diseases at bay. Lutein, a carotenoid from the marigold flower, is a very well-known ingredient in the management of eye health. Lutein and zeaxanthin, put together, are commonly known as macular pigments. These pigments help in filtering the blue light, thus protecting the eyes from the harmful effects of the blue light emitted from the screens of electronic gadgets. However, recent studies have demonstrated that these macular pigments have a significant effect on improving cognition and overall brain health. A randomized, double-blind, placebo-controlled clinical study was conducted on lutein and zeaxanthin to determine their effect on cognitive performance. As a safety parameter, HbA1c was also recorded during the study. At the end of the study, the statistics on the data revealed that lutein and zeaxanthin have a positive impact on HbA1c levels. It was observed that the HbA1c of the subjects in the treatment group was significantly lower than that of those in the placebo group, and the values significantly improved during the treatment duration between weeks 1 and 5. As a result, the current study examines how lutein and zeaxanthin affect type 2 diabetes mellitus (T2DM), diabetic kidney disease (DKD), non-alcoholic fatty liver disease (NAFLD), and bone health in healthy individuals between the ages of 35 and 75.MethodsThe blood parameters that were measured in thirty individuals who were randomly divided into two groups are the basis for the present study. The trial consisted of two parallel treatment groups and was randomized, double-blind, placebo-controlled clinical research. Through advertising, healthy participants between the ages of 35 and 75 were identified in the community. Following screening, 30 participants were accepted into the trial and randomly assigned using a computer-based randomization methodology into the two model groups, G1 (Group 1-treated) and G2 (Group 2-placebo). The HbA1c level for type 2 diabetes was divided into three groups based on numerical values at various levels: “improved,” “no change,” or “unfavourable.” For instance, if the levels of HbA1c decreased, they were categorized as “improved,” while if they increased, they were categorized as “unfavorable.” The safety profile of the supplement and any potential negative effects on the kidneys are evaluated using renal function testing. The tests help determine whether the supplement is altering kidney function markers such as creatinine, blood urea nitrogen, and serum urea. These factors can show whether the supplement damages the kidneys or affects their ability to function properly. After evaluating the levels of albumin, globulin, bilirubin, SGPT, SGOT, ALP, and GGTP, among various liver function markers, the effects of lutein supplementation on liver function were determined. According to a study by Takeda et al., taking lutein for four weeks significantly increased the amount of cortical bone in the femur and the overall amount of femoral bone mass. This improvement was quantified by dual X-ray absorptiometry and microcomputed tomography (CT) assessments of bone mineral density.ResultsA measure of blood sugar levels called estimated average glucose level (eAG), which is generated from HbA1c, showed similar patterns. At visit 1, the treatment group (group 1, Lutein and Zeaxanthin) reported an average eAG of 135.54, whereas the placebo group (group 2, Placebo) exhibited an eAG of 119.98. Before receiving treatment, group-1’s mean eAG was naturally higher than that of group-2. The mean BUN values at visit 1 for the treatment group (group 1, Lutein and Zeaxanthin) were 10.83, while they were 10.13 for the control group (group 2, Placebo). Groups 1 and 2 showed BUN levels of 11.03 and 10.7, respectively, during visit 5. The mean serum urea levels for groups 1 and 2 were 23.2 and 21.69, respectively. The mean values for groups 1 and 2 at visit 5 appeared to be 23.62 and 22.91, respectively, after 5 weeks. When creatinine levels were evaluated at visit 5, they were practically identical to those at visit 1 (1.02 and 0.99 mg/dL for groups 1 and 2, respectively). The mean values for creatinine during visit 1 were 1.03 and 0.985 mg/dL, respectively. At visit 1, the average albumin levels for groups 1 and 2 were 4.32 and 4.61, respectively. The albumin levels in G1 and G2 were 4.62 and 4.77 mg/dL at visit 5, after receiving therapy for 5 weeks. G1 and G2 exhibited total bilirubin levels of 0.609 and 0.547 mg/dL, respectively, during visit 1. For G1 and G2, the respective readings on the visit-5 were 0.633 and 0.662. During visit 1, the total bilirubin levels for G1 and G2 were 0.183 and 0.176 mg/dL, respectively. For G1 and G2, the respective readings during Visit-5 were 0.217 and 0.219 mg/dL. Throughout this clinical trial, there were no severe adverse effects.ConclusionClinical investigations have shown that the Lutein and Zeaxanthin is safe for bone, kidney, liver, and diabetes health. It was also noted that the Lutein supplementation helped in managing the HbA1c levels. Thus this study helps in establishing the positive effects of Lutein supplementation in people with impaired blood glucose levels.

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“…29 Serum ALP was measured using a Beckman Coulter DxC800 or DxC600i Synchron clinical system based on the kinetic rate approach by utilizing a 2-amino-2-methyl-1-propanol (AMP) buffer. 23…”

Section: Papermentioning

confidence: 99%

“…21,22 Total ALP and bone-specific ALP are byproducts generated during bone remodeling and reflect the bone turnover rate. 23 Additionally, total serum ALP level is considered a potential biomarker of bone formation 20 and can help assess the presence or absence of osteoporosis. 19 However, the relationship between serum total ALP and BMD is controversial, and there is no research on the effect of egg consumption on serum ALP levels.…”

Section: Introductionmentioning

confidence: 99%

Whole egg consumption in relation to bone health of the US population: a cross-sectional study

Shi,

Liu,

Hang

et al. 2024

Food Funct.

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The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Cited by 24 publications

References 27 publications

The correlation between serum levels of alkaline phosphatase and bone mineral density in adults aged 20 to 59 years

The correlation between serum levels of alkaline phosphatase and bone mineral density in adults aged 20 to 59 years

Safety Assessment of Lutein and Zeaxanthin Supplementation and Its Effects on Blood Glucose Levels, Kidney Functions, Liver Functions and Bone Health - A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Whole egg consumption in relation to bone health of the US population: a cross-sectional study

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