The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy

Altuhafi, Abdulateef; Altun, Muhammed; Hadwan, Mahmoud Hussein

doi:10.52547/rbmb.10.2.164

Cited by 18 publications

(7 citation statements)

References 40 publications

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“…Similarly, there were no significant differences in genes related to oxidative stress, including GSH-PX family members GPX1, GPX4, GPX7 , and GPX8 . GSH-PX is a key enzyme antioxidant that protects cells from oxidative damage by reducing the rising state of oxidative stress, eliminating the toxicity of peroxide, and transforming it into a non-toxic substance ( 30 ). Additionally, ROS can also act as a signal molecule to transcriptionally activate the apoptosis signaling pathways, promote intestinal inflammatory response, and start the intestinal cell apoptosis program ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of short-distance transportation on physiological indexes, intestinal morphology, microbial community, and the transcriptome of the jejunum in weaned piglets

Yang

Zhou

et al. 2023

Front. Vet. Sci.

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Transportation of livestock is unavoidable in animal production. A total of 72 piglets were randomly divided into the CON group and the TSG group, and the piglets in CON group were transported for two hours. The purpose of this study was to determine the effects of short-distance road transportation lasting 2 h on the jejunum of weaned piglets. Our results showed that compared with the control group, there was no impact on the growth performance of piglets in the transport group (P > 0.05). The concentrations of cortisol, heat shock protein (HSP)70, HSP90, C-reactive protein, interleukin (IL)-6, IL-8, IL-12, and interferon-γ and the activity of reactive oxygen species were increased in the jejunum of piglets in the transport group (P < 0.05 compared with the control group). The concentrations of glutathione peroxidase, claudin-1, occludin, and zonula occludens-1 showed no between-group differences (P > 0.05). Regarding intestinal morphology, the transport group showed infiltration of a small amount of lymphocytes into the jejunum mucosa epithelium that was accompanied by edema of the lamina propria, whereas the control group showed no obvious abnormalities. At the genus level, in the transport group, the 16S rRNA sequencing revealed a downward trend in the relative abundance of Lactobacillus and an upward trend in the relative abundance of Muribaculaceae_unclassified. There was also increased mRNA expression of genes associated with inflammation in the transport group, but the genes and pathways related to apoptosis were not activated. In summary, weaned piglets undergoing 2 h of short-distance road transportation showed stress and inflammatory reactions of the jejunum but did not exhibit oxidative damage or activation of the apoptosis pathway of the jejunum. Furthermore, the growth performance of the piglets was not affected by the trip.

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Section: Discussionmentioning

confidence: 99%

Effects of short-distance transportation on physiological indexes, intestinal morphology, microbial community, and the transcriptome of the jejunum in weaned piglets

Yang

Zhou

et al. 2023

Front. Vet. Sci.

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“…During the diabetic condition, a decreased GPx activity was reported. 57 The over-accumulation of hydroxyl radicals and depleted antioxidants are the major factors of oxidative stress. 58 Here, our present findings represented that the GDM animals displayed increased MDA and decreased SOD, CAT, GST, and GPx activities.…”

Section: Discussionmentioning

confidence: 99%

Visnagin Attenuates Gestational Diabetes Mellitus in Streptozotocin-induced Diabetic Pregnant Rats via Regulating Dyslipidemia, Oxidative Stress, and Inflammatory Response

Yang¹,

Lü²,

Yang³

2022

Pharmacognosy Magazine

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Background: Gestational diabetes mellitus (GDM) is a condition of glucose intolerance and insulin resistance only diagnosed during pregnancy. GDM has exhibited several adverse effects on both mother and offspring. The current research focuses on discovering visnagin’s beneficial properties against the streptozotocin (STZ)-induced GDM in rats via alleviating the inflammation and oxidative stress. Materials and Methods: GDM was caused in the pregnant rats by the administration of 25 mg/kg of STZ by the intraperitoneal route and then treated with 20 mg/kg of visnagin for 20 consecutive days. The rats’ body weight was measured, and fasting blood glucose (FBG) status was determined using a standard glucometer. The contents of total cholesterol (TCh), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were assessed using kits. The MDA level, total antioxidant capacity (TAC) status, and activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) were determined using assay kits. Kits also assessed the contents of TNF-α and IL-1β. The contents of TNF-α and IL-1β effectively improved the body weight and decreased the FBG status in the GDM rats. The visnagin also decreased the TCh, TG, and LDL, and elevated the HDL content. The content of MDA was decreased and the visnagin treatment increased SOD, CAT, GST, and GPx, and the visnagin treatment increased SOD, CAT, GST, and GPx activities SOD, CAT, GST, and GPx activities. The visnagin effectively decreased the STZ-induced histopathological alterations in the pancreas. Conclusion: Altogether, our investigation results suggest a beneficial role visnagin against STZ-induced GDM in rats via inhibiting the inflammatory responses. Hence, it can be a talented therapeutic candidate for the successful management of GDM.

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“…The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and reduce free hydrogen peroxide to water. Low levels of GPx observed in type 2 diabetes are associated with macroalbuminuria, which was correlated to the stage of diabetic nephropathy 34 . The Glutathione peroxidase results were given in Table 16 and Figure 16.…”

Section: Glutathione Peroxidase (Gpx)mentioning

confidence: 94%

Pharmacological Evaluation of Polyherbal Formulation for Nephroprotective Activity

Thirugnanasambantham¹,

Devi

Jayshree

et al. 2022

JNR

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The kidney plays an essential role in removing waste products and drugs from the body and maintaining balanced body fluids. It gets affected due to many factors, notably, diabetes and high blood pressure. Nowadays, naturally, derived products are essential in curing various ailments and are safe and cost-effective. The purpose of this study is to assess the toxicity profile and nephroprotective effect of a proprietary polyherbal formulation in Wistar albino rats for gentamicin-induced nephrotoxicity. The Polyherbal formulation was procured from Rumi Herbals Private Limited. Acute toxicity experiments were conducted in Wistar rats using the Gentamicin induced nephrotoxicity model as per OECD standards 423, and the efficacy was assessed using the Gentamicin induced nephrotoxicity model. The formulation was proven safe up to 2000mg/kg orally in an acute toxicity study, with no behavioral abnormalities and no fatality. The gentamicin 80 mg/kg i.p for 7 days induced nephrotoxicity in rats showed a significant (P<0.05) increase in the renal parameters and reduction in antioxidant levels compared with day 0. Whereas test drug-treated groups at a low dose (200 mg/kg) and high dose (400 mg/kg) showed significant (P<0.05) reduction in elevated renal parameters and improvement in antioxidant levels compared with the disease control group. According to the histopathological interpretation of isolated kidneys, this formulation protects from kidney damage and restores typical kidney architecture. From the results, the proprietary polyherbal formulation has shown effective nephroprotective activity may be due to the presence of secondary metabolites/phytoconstituents. Further investigation is essential to focus on the mechanism involved and standardize the active phytoconstituents responsible for the nephroprotective activity.

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The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy

Cited by 18 publications

References 40 publications

Effects of short-distance transportation on physiological indexes, intestinal morphology, microbial community, and the transcriptome of the jejunum in weaned piglets

Effects of short-distance transportation on physiological indexes, intestinal morphology, microbial community, and the transcriptome of the jejunum in weaned piglets

Visnagin Attenuates Gestational Diabetes Mellitus in Streptozotocin-induced Diabetic Pregnant Rats via Regulating Dyslipidemia, Oxidative Stress, and Inflammatory Response

Pharmacological Evaluation of Polyherbal Formulation for Nephroprotective Activity

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