The Correlation Between RDW, MPV and Weight Indices After Metabolic Surgery in Patients with Obesity and DM/IGR: Follow-Up Observation at 12 Months

Zhou, Li; Lin, Shibo; Zhang, Fan; Ma, Yi-Ping; Fu, Zhen-Yan; Gong, Yingyun; Hu, Dandan; Ma, Shuai; Ye, Xuan; Qian, Leihang; Geng, Xiaomei; Yang, Ningli; Liang, Hui; Zhou, Hongwen

doi:10.1007/s13300-020-00897-9

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…In our study, although there was no statistically significant difference in the group with B12 deficiency, we found that the mean MPV value increased, and the platelet count was lower than in the control group. This was in agreement with the work of Li et al This increase in MPV can be explained by the larger, newly synthesized young platelets to compensate for the decrease in platelets [20].…”

Section: Discussionsupporting

confidence: 93%

B12 vitamin eksikliği olan kişilerin tam kan, ortalama trombosit hacmi (MPV) ve nötrofil-lenfosit oranlarının (NLR) değerlendirilmesi

DURMAZ

2022

Family Practice and Palliative Care

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Introduction: It was aimed to investigate the effects of vitamin B12 deficiency on blood tests, mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR), which is one of the inflammation markers.Methods: Our study is a case-control study of 375 patients. 170 patients with low B12 (<130 pg/dL) were accepted as the experimental group, and 205 individuals with normal B12 levels were accepted as the control group. Between these two groups, white blood cells (WBC), platelet count (Plt), hemoglobin (Hgb), mean erythrocyte volume (Mean Corpuscular Volume-MCV), mean platelet volume (Mean Platelet Volume-MPV), neutrophil, lymphocyte counts, and neutrophil -lymphocyte ratios (NLR) were examined.Results: The mean age was 48.45 ±17.497 years in the B12 deficient group and 51.93 ±16.175 years in the control group. The mean of vitamin B12 in the deficient group was 101.41 ± 20.50 pg/mL (min-max 37-130), while it was 257.24 ± 88.13 pg/mL (131–498) in the control group. It was observed that there was no statistically significant difference between WBC, Hgb, Plt, neutrophil, lymphocyte, MVC, MPV and NLR values.Conclusion: In our study, we could not find a significant relationship between B12 deficiency and blood tests. In previous studies, there has been information that MPV values are affected by B12 deficiency. In our study, we found that there was no significant relationship between B12 deficiency and MPV or NLR (p > 0.05). There is a need for new studies on how B12 deficiency will change as the degree and duration of B12 deficiency increases, especially its effect on atherogenic events.

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Section: Discussionsupporting

confidence: 93%

B12 vitamin eksikliği olan kişilerin tam kan, ortalama trombosit hacmi (MPV) ve nötrofil-lenfosit oranlarının (NLR) değerlendirilmesi

DURMAZ

2022

Family Practice and Palliative Care

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“…In this study, we also observed that patients with obesity had higher pre-operative RDW and NLR, which are risk factors for cardiovascular mortality described in previous studies (35)(36)(37). Their elevation may be associated with obesityrelated lower-grade chronic inflammation and inflammatory mechanisms of aortic dissection (38)(39)(40). Of note, despite the differences in baseline characteristics being unavoidable, gender, past medical history besides hypertension, surgical details, and treatment management did not differ between the two groups.…”

Section: Discussionsupporting

confidence: 76%

Obesity Increases In-Hospital Mortality of Acute Type A Aortic Dissection Patients Undergoing Open Surgical Repair: A Retrospective Study in the Chinese Population

Pan

Xing

Yang

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveThe prevalence of obesity is increasing worldwide, and the role of the obesity paradox in cardiovascular surgery remains controversial. In this study, we redefined obesity according to the Chinese criteria and examined the relationship between obesity and in-hospital mortality in patients with acute type A aortic dissection (AAD) undergoing open surgical repair.Materials and MethodsA total of 289 patients with AAD (between 2014 and 2016) were divided into the non-obese group and obese group for correlation analysis, general information, demographic factors, blood biochemistry, surgical details, and complications, which were used as covariates. Survival was estimated by the Kaplan–Meier method, and any differences in survival were evaluated with a stratified log-rank test. Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression were used to evaluate the effect and interaction of obesity on surgical mortality.ResultsAll the 289 patients had a mean age of 48.64 (IQR 44.00–55.00) and 74.39% were men. Of the 289 patients, 228 were non-obese (78.89%) and 61 were obese (21.11%). Patients with obesity were younger and more prone to unstable blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], preoperative hypoxemia and delirium, prolonged operative time, and surgical wound deep infection (p < 0.05). In the fully adjusted model, we observed an increased risk of in-hospital mortality in patients with obesity after fine-tuning other covariates including age and sex (HR = 2.65; 95% CI = 1.03 to 6.80; p = 0.042). The interaction suggested that obesity was more likely to cause death in elderly patients (age ≥ 60), although it was more common in younger patients (test for interaction, p = 0.012).ConclusionObesity, interacting with age, increases the risk of in-hospital mortality in patients with AAD undergoing open surgical repair. Although more verification is needed, we believe these findings provide further evidence for the treatment of AAD.

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“…Other blood biomarkers were also considered as weight loss predictors after bariatric surgery; Wise ES et al showed that preoperative red blood cell distribution width (RDW), also a biomarker of inflammation and oxidative stress, is directly correlated with surgical success after laparoscopic Roux-en-Y gastric bypass one year after surgery [30]. Similar results were reported by others [31] as regards the role of preoperative RDW and mean platelet volume as predictors of weight loss after sleeve gastrectomy and bypass surgery.…”

Section: Discussionmentioning

confidence: 68%

Monocyte to high-density lipoprotein cholesterol ratio is correlated with baseline anthropometric measurements in patients with obesity but not with weight-loss process after sleeve gastrectomy - An observational cohort study

Sala,

Kiss,

Daniealopol

et al. 2024

Revista Romana De Medicina De Laborator

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Introductionː A strong connection between inflammation and obesity was repeatedly described, with the latter defined as a chronic low-degree systemic inflammatory state. This study analyzed the correlations between inflammatory blood indexes and both baseline anthropometric measurements and the weight–loss process after bariatric surgery. Methodsː An observational study was conducted on patients with obesity admitted for metabolic surgery in a private and a public hospital. The primary endpoints were to establish correlations between baseline inflammatory ratios i.e. neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR), monocyte to lymphocyte (MLR), monocyte to high-density lipoprotein cholesterol (MHR) ratios, systemic inflammatory index (SII) and anthropometric measurements. Secondary endpoints were to find out if these ratios measured at baseline are predictive factors for weight loss after bariatric surgery. Results: In the present study, we included 191 patients, mean age 39.1±10,7 and mean BMI 42,2±6,5 kg/m2. There was a positive correlation between MHR and all anthropometric measurements taken at baseline; a direct correlation was also found for MLR in regards to initial weight and waist circumference. No statistical correlations were found between the above-mentioned indexes and the weight loss process (measured as a percentage of excess weight loss - %EWL) at different follow-up timeframes. Conclusionsː Monocyte to high-density lipoprotein cholesterol ratio (MHR) was positively associated with baseline anthropo-metric measurements in patients with obesity. The above-mentioned inflammatory ratios did not correlate with the weight loss process after bariatric surgery, thus they should not be used as predictors of good postoperative results.

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The Correlation Between RDW, MPV and Weight Indices After Metabolic Surgery in Patients with Obesity and DM/IGR: Follow-Up Observation at 12 Months

Cited by 6 publications

References 31 publications

B12 vitamin eksikliği olan kişilerin tam kan, ortalama trombosit hacmi (MPV) ve nötrofil-lenfosit oranlarının (NLR) değerlendirilmesi

B12 vitamin eksikliği olan kişilerin tam kan, ortalama trombosit hacmi (MPV) ve nötrofil-lenfosit oranlarının (NLR) değerlendirilmesi

Obesity Increases In-Hospital Mortality of Acute Type A Aortic Dissection Patients Undergoing Open Surgical Repair: A Retrospective Study in the Chinese Population

Monocyte to high-density lipoprotein cholesterol ratio is correlated with baseline anthropometric measurements in patients with obesity but not with weight-loss process after sleeve gastrectomy - An observational cohort study

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