The correlation between patent foramen ovale and brain ischemia in plateau residents

Liu, Gang; Feng, Zhao; Feng, Fan; Xue, Changju; Liu, Fei; Xie, Xiaoting

doi:10.1186/s12872-021-02172-6

Cited by 3 publications

(4 citation statements)

References 27 publications

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“… 113 In plateau residents, 71% of PFO patients showed ischemic lesions on cranial MRI, a much higher occurrence than that in healthy controls (19%). 114 The diameter of PFOs was correlated with the incidence and number but not the location of cerebral ischemic lesions. Single and multiple cerebral ischemic lesions were observed in patients with PFO diameters of less than 2 mm and more than 4 mm, respectively.…”

Section: Discussionmentioning

confidence: 96%

“…Single and multiple cerebral ischemic lesions were observed in patients with PFO diameters of less than 2 mm and more than 4 mm, respectively. 114 Nevertheless, in a retrospective case-control study, researchers failed to find a higher incidence of high-risk PFOs in the Stoke + MA group, arguing that they were not the primary contributors to the increased risk of MA stroke. 56 …”

Section: Discussionmentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

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Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Zhang,

Zhou

et al. 2023

JPR

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Background Both migraine and stroke heavily burden individuals, health systems, and society. The migraine-stroke association is of concern and has been studied widely. Our objective is to explore and overview the current research status and emerging trends. Materials and Methods Studies on migraine-stroke association from January 2013 to May 2023 were retrieved and screened from the Web of Science Core Collection (WOSCC) database. Records fulfilling the selection criteria were downloaded and imported into CiteSpace for data mining and visualization. Results A total of 862 papers on migraine-stroke association were included. Annual publications grew slowly. The United States and European countries dominated research in this area. Harvard University published the largest number of articles, while the University of London was most active with other institutions. Ayata Cenk contributed the most articles, while KURTH T and NEUROLOGY were co-cited most. Research hotspots included migraine with aura, ischemic stroke, patent foramen ovale, cortical spreading depolarization, meta-analysis, cross-sectional study, and risk factors. Pathophysiology and small vessel disease represented research frontiers and emerging trends. Conclusion Our study scientifically outlines the migraine-stroke association over the past decade, presenting useful information.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Zhang,

Zhou

et al. 2023

JPR

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“…Right-heart contrast echocardiography was performed to identify the presence of right-to-left shunting, by using agitated saline (80%) combined with air (10%) and the patient’s own blood (10%) when the patient was at rest or performing a Valsalva maneuver. Microbubbles were detected in the left atrium during 3 to 5 cardiac cycles [ 10 , 11 ].…”

Section: Study Population and Methodsmentioning

confidence: 99%

The association between patent foramen ovale and unexplained syncope in pediatric patients

Zou,

Wang,

Liu

et al. 2024

Ital J Pediatr

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Background Patent foramen ovale (PFO) is associated with transient ischemia attack (TIA) or stroke, paradoxical embolism, and migraines. PFO closure decreases the recurrent incidence of cerebral ischemic events and reduces the incidence of syncope in adults. However, whether PFO is associated with syncope in pediatric patients has not been investigated. Methods 1001 pediatric patients (aged 4 to 17 years, mean age 10.31 ± 2.61 years, 519 males) who complained of unexplained syncope, palpitation, headache, dizziness and chest pain and were hospitalized in the Syncope Ward, The Second Xiangya Hospital, Central South University between January 2013 and April 2022 were recruited. Children with definite etiology of syncope, neurological, cardiogenic, psychological and other system diseases were excluded. PFO was measured by transthoracic echocardiography and right-heart contrast echocardiography was performed to identify the presence of right-to-left shunting. The demographic data and medical records were retrospectively reviewed and analyzed. Results 276 cases were included in the simple syncope group, 379 cases in the headache/dizziness group, 265 cases in the chest pain group, and 81 cases in the palpitation group. The incidence of PFO between the four groups was insignificant (4.71%, 4.74%, 4.15%, 6.17%, respectively, P = 0.903). Multivariate Logistic regression demonstrated that PFO is not associated with the increased risk of syncope (P = 0.081). Conclusion PFO may not increase the risk of syncope in pediatric patients. Further study may include a large and multicenter sample to investigate the association between PFO and unexplained syncope.

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Predictive value of transesophageal echocardiography combined with contrast transthoracic echocardiography for embolic stroke of undetermined source

Huang,

Wang

2023

Perfusion

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Objective In this study, we aimed to assess the predictive value of transesophageal echocardiography (TEE) combined with contrast transthoracic echocardiography (cTTE) for embolic stroke of undetermined source (ESUS). Methods A total of 52 patients with ESUS were examined by TEE and cTTE. The detection rate of patent foramen ovale (PFO) and right-to-left shunt (RLS) grade were compared in patients with ESUS between cTTE alone and cTTE combined with TEE. The Risk of Paradoxical Embolism (RoPE) score, PFO diameter, and PFO length of patients with PFO-associated ESUS and non-PFO-associated ESUS were compared by cTTE alone and cTTE combined with TEE. The receiver operating characteristic (ROC) curve was utilized to determine the effect of RoPE score and PFO diameter on patients with PFO-associated ESUS. Results The positive rate of PFO detected by cTTE alone (46.15%) was lower than that detected by cTTE combined with TEE (69.23%). The proportion of patients with RLS grade I + II + III detected by cTTE combined with TEE (69.23%) was higher than that detected by cTTE alone (46.15%). Both the RoPE score and PFO diameter were significantly greater in the patients with PFO-associated ESUS than in the patients with non-PFO-associated ESUS ( p < .05). The combination of RoPE score and PFO diameter had the largest area under the ROC curve (AUC = 0.875), which was larger than the AUC alone of RoPE score (AUC = 0.819) and PFO diameter (AUC = 0.783) ( p < .05). Conclusion The combination of cTTE and TEE is helpful to the diagnosis of ESUS patients caused by PFO and to judge the degree of RLS.

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The correlation between patent foramen ovale and brain ischemia in plateau residents

Cited by 3 publications

References 27 publications

Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

The association between patent foramen ovale and unexplained syncope in pediatric patients

Predictive value of transesophageal echocardiography combined with contrast transthoracic echocardiography for embolic stroke of undetermined source

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