The Correlation Between Migraine and Patent Foramen Ovale

Liu, Kai-Ming; Wang, Brian Z.; Ye, Hao; Song, Shunfeng; Pan, Mengxiong

doi:10.3389/fneur.2020.543485

Cited by 48 publications

(40 citation statements)

References 95 publications

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“…There is a dose-effect relationship between PFO and migraine. Larger PFO, permanent PFO, and anatomical variation of PFO can aggravate RLS, which is associated with migraine attacks [11]. Meanwhile, PFO is more associated with MA than MoA.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have found that the incidence of patent foramen ovale (PFO) in migraine patients is signi cantly higher than that in normal people [9,10]. The relationship between PFO and migraine has been studied and is a major concern [11]. Vestibular migraine is considered to be related to vestibular symptoms caused by migraine mechanisms, and its pathogenesis may be related to ion channel defects, enhanced cortical excitability, and central sensitisation, which are caused by genetic susceptibility [12,13].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Paroxysmal Vertigoes and Right-To-Left Shunt: A Large Observational Study

Liu

Tian

Hong

et al. 2021

Preprint

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Background The association between paroxysmal vertigo and right-to-left shunt (RLS) is rarely reported. We investigated the incidence and correlation of RLS in patients with different paroxysmal vertigo diseases. Methods This large observational study included patients with paroxysmal vertigo from seven different hospitals in China from 2017 to 2021 (NCT04939922). Migraine patients within the same period were included for comparison. Demographic data and medical history were collected, contrast transthoracic echocardiography (cTTE) was performed, and the clinical features, dizziness handicap inventory, and incidence of RLS in each group were recorded. Results This study used a consecutive sampling of 4536 patients from seven centres, and a total of 2751 patients were enrolled. The proportion of RLS in patients with migraine with aura (MA), migraine without aura (MoA), vestibular migraine (VM) with headache, VM without headache, and benign recurrent vertigo (BRV) was significantly higher than that in patients with benign paroxysmal positional vertigo (BPPV), Meniere’s disease (MD), and vestibular paroxysmia (VP) (P<0.05). There was no statistical difference between the frequency of RLS in patients with BRV and those with MoA (P=0.931), MA (P=0.997), VM with migrainous headache (P=0.787), and VM without migrainous headache (P=0.754). There was a positive correlation between the RLS grade and the dizziness handicap inventory scores of VM and BRV patients (P<0.01). Conclusions RLS was significantly associated with BRV and VM. RLS may be involved in the pathogeneses of BRV and VM and may serve as a reference index for the differential diagnosis of central and peripheral vertigo. Trial registration: CHRS, NCT04939922, registered 14 June 2021- retrospectively registered, https://register.clinicaltrials.gov

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship Between Paroxysmal Vertigoes and Right-To-Left Shunt: A Large Observational Study

Liu

Tian

Hong

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, Schwerzmann et al have demonstrated that the number of people having small RLS among migraine patients and healthy subjects was similar but a moderate or large RLS occurred more frequently in the migraine group compared to healthy controls [22]. More remarkably, it has been argued that larger PFO, persistent PFO, and complex tissue structures may cause more RLS to increase the incidence of migraine [23]. These findings may reflect the "dose-response" relationship between RLS and migraine.…”

Section: Migraine Aura and Patent Foramen Ovalementioning

confidence: 99%

High Eosinophil Rates in Patients With Right-to-Left Shunts: An Expected Role, or an Unexpected Risk?

Karakuş¹,

Okutucu²

2021

Cureus

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Background and objectiveEosinophils are associated with thromboembolic events. Since eosinophils are eliminated in the pulmonary vasculature, right-to-left shunt (RLS) through patent foramen ovale may increase eosinophils in the peripheral blood. In this report, we evaluated the eosinophils of patients with regard to the presence of RLS and its quantity. Patients and methodsIn this retrospective observational study, we analyzed the complete blood cell count (CBC) of patients with RLS (n=47) and without RLS (n=31) diagnosed by contrast echocardiography (CE). RLS was identified as mild (5-10 bubbles) and moderate shunt (10-25 bubbles). ResultsAge and CBC were not significantly different between the groups, with the exception of eosinophils. Patients with RLS had higher eosinophils percentage compared to patients without RLS (3.1 ±1.5 vs. 1.7 ±0.7, p=0.001). Additionally, eosinophils percentage was significantly higher in the mild RLS group (2.4 ±0.9 vs. 1.7 ±0.7, p=0.016) and the moderate RLS group (4.3 ±1.6 vs. 1.7 ±0.7, p=0.001) compared to normal subjects. Also, it was significantly higher in the moderate RLS group compared to the mild group (4.3 ±1.6 vs. 2.4 ±0.9, p=0.001). ConclusionsEosinophils percentage was higher in patients with mild and moderate RLS compared to normal individuals. Moreover, the eosinophil rate was higher in patients with moderate RLS than in patients with mild RLS.

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“…Інші теорії МІ пов'язані з ендотеліальною дисфункцією та гіперкоагуляцією під час аури [15]. Також, мігрень може бути асоційована з певними патологічними станами (наприклад, відкрите овальне вікно [16] і диссекція хребтової артерії [17]). Той факт, що певні генетичні синдроми (наприклад, церебральна аутосомно-домінантна артеріопатія з підкірковими інфарктами та лейкоенцефалопатією -CADASIL) асоціюються з мігренню та інсультами, може свідчити про генетичні механізми, і, ймовірно, вроджені зміни стінки дрібних мозкових судин [18].…”

Section: результати та їх обговоренняunclassified

Клінічний Випадок Можливої Мігрені З Аурою, Ускладненої Мігренозним Інфарктом

Нікіфорова¹,

Саник²,

Дельва³

2021

Med. and Ecol. probl.

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We present a clinical case of ischemic stroke in a man with a new-onset migraine attack. Clinical case. A 25-year-old man was admitted to the acute cerebrovascular department due to severe throbbing headache in the left temporal area, vomiting, impaired vision on the right and numbness of the right leg. Complaints appeared abruptly in the form of scotoma in the right visual field. 20 minutes later, severe throbbing headache, nausea and numbness of the right leg developed. The event was preceded by sleep deprivation for 2 days. The patient’s mother has migraine with aura. Previously, the patient never had such attacks. On examination: right-sided homonymous upper-quadrant hemianopsia, hypoesthesia of the right leg. Brain MRI - focal hyperintensity at T2 and DWI in the left occipital region (acute ischemic stroke). The patient took aspirin at a dose of 300 mg for the first day, then 100 mg per day and valproic acid at a dose of 1200 mg per day. Two days after hospitalization, the patient experienced recovery of sensitivity in the right leg and regression of right-sided homonymous upper quadrant hemianopsia to small scotoma. The patient was discharged on the 5th day with a small right scotoma. It is recommended to continue taking aspirin 100 mg/day and valproic acid 1200 mg/day for the secondary prevention of migraine attacks and stroke. Discussion. The peculiarities of this case include the lack of history of migraine (at least 5 or more migrainous headache attacks) and the development of severe migraine attack with prolonged aura symptoms, which was triggered by sleep deprivation and eventually evolved into ischemic stroke. Conclusions. It is necessary to consider the possibility of ischemic stroke even in the cases of a new-onset migraine attack. If migrainous aura duration exceeds 60 minutes, it is necessary to perform a brain MRI to detect the early signs of cerebral ischemia.

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The Correlation Between Migraine and Patent Foramen Ovale

Cited by 48 publications

References 95 publications

The Relationship Between Paroxysmal Vertigoes and Right-To-Left Shunt: A Large Observational Study

The Relationship Between Paroxysmal Vertigoes and Right-To-Left Shunt: A Large Observational Study

High Eosinophil Rates in Patients With Right-to-Left Shunts: An Expected Role, or an Unexpected Risk?

Клінічний Випадок Можливої Мігрені З Аурою, Ускладненої Мігренозним Інфарктом

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