The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study

Wu, Ying; Shi, Xiaoguang; Tang, Xulei; Li, Yongze; Tong, Nanwei; Wang, Guixia; Zhang, Jinan; Wang, Youmin; Ba, Jianming; Chen, Bing; Du, Junbao; He, Lin; Lai, Xiulan; Li, Yanbo; Chi, Haiyi; Liao, Er-Yuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Xue, Yue; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jihe; Zhu, Mei; Wang, Teng; Shan, Zhongyan

doi:10.4158/ep-2020-0008

Cited by 23 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In autoimmune thyroid diseases (AITD), thyroid autoantibodies not only cause damage to thyroid tissues, but may also have potential out-thyroid actions ( 16 ). Recently, studies have shown that the presence of thyroid antibodies are involved in glucose and lipid metabolic disorders ( 17 , 18 ). In addition, thyroid autoimmune may have a tumor-promoting role in breast cancer carcinogenesis ( 19 ) and may act as an independent CVD risk factor by promoting chronic inflammation ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

Zhang

Chen

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundPrevious studies have shown that metabolic dysfunction associated fatty liver disease (MAFLD) is associated with thyroid hormones (THs), immunity, and inflammation status, but few studies involved thyroid autoimmunity. This study aimed to evaluate the role of THs, thyroid autoantibodies, inflammatory biomarkers in MAFLD, its cofactors, and other possible determinants.Materials and MethodsIn the study, a total of 424 Chinese patients were selected and categorized as non-MAFLD and MAFLD. Serum thyroid hormone, thyroid autoantibody and high-sensitive C-reactive protein (hsCRP) levels were measured. The data of blood pressure, the serum lipid profile, glucose and liver enzymes were collected. The differences and association between research findings were examined and analyzed by Wilcoxon Signed Rank Test, One-Way ANOVA test and Multiple Logistic Regression models.ResultsThe study showed significant increase in the prevalence of MAFLD with high thyroid stimulating hormone (TSH) levels (P < 0.01) and abnormal high-sensitive C-reactive protein (hsCRP) levels (P < 0.01). The proportion of MAFLD patients decreased significantly with the rise of free thyroxine (FT4) (P = 0.04), thyrotropin receptor antibodies (TRAb) (P < 0.01), anti-thyroglobulin antibodies (TgAb) (P < 0.01), and thyroid peroxidase antibodies (TPOAb) levels (P < 0.01). Based on logistic regression analysis, MAFLD was significantly associated with lower levels of TgAb (P < 0.01), TPOAb (P < 0.01), and higher levels of hsCRP (P < 0.01) in male. In female, elevated TgAb (P < 0.01) may be a protective factor, while higher levels of hsCRP (P < 0.01) showed increased risk of MAFLD. Logistic models were adjusted for age, BMI, SBP, DBP, FBG, ALT, AST, TC, TG, LDL, HDL.ConclusionsTaken together, TgAb may be a potential protective factor for MAFLD and elevated hsCRP level should be considered as an independent risk factor for MAFLD in both genders. TPOAb also demonstrated protective effect, but only in male. The prevalence of MAFLD increased with higher TSH levels and lower FT4, TRAb levels, but no significant association were found. However, Our findings provide a new insight into the pathogenesis of MAFLD by further investigating the impact of THs, thyroid autoimmunity, and inflammation on MAFLD patients.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

Zhang

Chen

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Obesity is a variable known to be associated with IR and GDM, as it was also the case in our regression analysis ( 8 , 15 , 16 ). In one study, obesity, high LDL and hyperuricemia were positively correlated with TAI in euthyroid subjects, and the so-called ‘immunometabolism’ highlights the relationship between the immune and hormonal system ( 17 ). Obesity might increase the susceptibility to harbor TAI with leptin as a peripheral determinant, which can decrease the function of regulatory T cells and increase the percentage of T helper 1 cells ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Association between thyroid autoimmunity and gestational diabetes mellitus in euthyroid women

Sitoris

Veltri

Ichiche

et al. 2022

European Thyroid Journal

View full text Add to dashboard Cite

Objective: Pregnant women with autoimmune (subclinical) hypothyroidism have an increased risk of developing gestational diabetes mellitus (GDM). However, this association remains controversial in euthyroid women with thyroid autoimmunity (TAI). Therefore, the aim of the study was to determine the association between TAI and GDM in euthyroid women in a logistic regression analysis with adjustments for baseline / demographic parameters. Methods: Cross-sectional study in 1447 euthyroid women who performed their biological work-up and oral glucose tolerance test (OGTT) in our center. At median 13 (11-17) weeks of gestation, TSH, free T4 and thyroid peroxidase antibodies (TPOAb) were measured, baseline characteristics recorded and an OGTT was performed between 24-28 weeks of pregnancy. Exclusion criteria were pre-pregnancy diabetes, assisted pregnancies, and women with (treated) thyroid dysfunction before or after screening. The diagnosis of GDM was based on 2013 WHO criteria, and TAI was defined as TPOAb levels ≥60 kIU/L. Results: Two hundred eighty women were diagnosed with GDM (19.4%), 26.1% in women with TAI and 18.9% in women without TAI (p=0.096). In the logistic regression analysis, TAI was associated with GDM in women older than 30 years (adjusted odds ratio (aOR) 1.68 (95% CI, 1.01-2.78); p=0.048). Maternal age >30 years, pre-pregnancy BMI ≥30 kg/m2 and another than Caucasian background were also associated with GDM; aOR 1.93 (95% CI, 1.46-2.56); p<0.001, 2.03 (95% CI, 1.46-2.81); p<0.001 and 1.46 (95% CI, 1.03-2.06); p=0.034, respectively. Conclusions: In older pregnant women, the presence of TAI in euthyroid women was associated with GDM. In line with literature data, (higher) age and BMI were strongly associated strongly with GDM.

show abstract

“…Tg is a glycoprotein that is mainly secreted by the thyroid follicular epithelium, and its expression in the healthy human body is low. 16 , 17 However, patients with thyroid cancer develop inflammatory responses due to thyroid tissue damage, which may induce the activation of thyroid epithelial cells, 18 thereby causing them to release more Tg. 19 Therefore, Tg is highly expressed in patients with thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Differential diagnostic value of the ResNet50, random forest, and DS ensemble models for papillary thyroid carcinoma and other thyroid nodules

et al. 2022

View full text Add to dashboard Cite

Objective To explore the differential diagnostic efficiency of the residual network (ResNet)50, random forest (RF), and DS ensemble models for papillary thyroid carcinoma (PTC) and other pathological types of thyroid nodules. Methods This study retrospectively analyzed 559 patients with thyroid nodules and collected thyroid pathological images and auxiliary examination results (laboratory and ultrasound results) to construct datasets. The pathological image dataset was used to train a ResNet50 model, the text dataset was used to train a random forest (RF) model, and a DS ensemble model was constructed from the results of the two models. The differential diagnostic values of the three models for PTC and other types of thyroid nodules were then compared. Results The DS ensemble model had the highest sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (85.87%, 97.18%, 93.77%, and 0.982, respectively). Conclusions Compared with Resnet50 and the RF models trained only on imaging data or text information, respectively, the DS ensemble model showed better diagnostic value for PTC.

show abstract

The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study

Cited by 23 publications

References 34 publications

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

Association between thyroid autoimmunity and gestational diabetes mellitus in euthyroid women

Differential diagnostic value of the ResNet50, random forest, and DS ensemble models for papillary thyroid carcinoma and other thyroid nodules

Contact Info

Product

Resources

About