The correlation between LDL-C/HDL-C and Hypertension: a case control study

Abstract

Dyslipidemia is a risk factor of hypertension, which can promote the occurrence and development of hypertension. In this study, we collect data of 362 elderly patients to explore the correlation between blood lipid indexes and hypertension in the elderly population. Patients were divided into two groups : hypertensive group and control group. Multivariate logistic regression analysis, Spearman correlation analysis and receiver operating characteristics (ROC) curve were used to analyze the correlation between blood lipid and hypertension and its predictive value for hypertension. We found that The levels of LDL-C/HDL-C in hypertensive group were higher than those in control group, and the levels of LDL-C/HDL-C in moderate and severe hypertension groups were higher than those in mild hypertension group (P < 0.05). Multivariate logistic regression analysis showed that LDL-C/HDL-C was an independent risk factor for hypertension. Correlation analysis showed that LDL-C/HDL-C was positively correlated with the severity of hypertension (r = 0.580, P < 0. 01). ROC curve analysis showed that area under the curve (AUC) of LDL-C/HDL-C in predicting hypertension was 0. 937 (95%CI: 0.914-0. 961, P < 0.01). When the cut-off value was 4.276, the specificity and sensitivity were 96.2% and 75. 20%. In conclusion, LDL-C/HDL-C is an independent risk factor for hypertension and has predictive value for hypertension.