The Correlation between Hand Grip Strength and Nutritional Variables in Ambulatory Cancer Patients

Pereira, Antonio G.B.; Zaia, Rebecca Dias; Souza, Gustavo Henrique Gandolfo; Luizeti, Bárbara Okabaiasse; Andreola, Ricardo; Vizzotto, Alvo Orlando; Ferrari, Ariana

doi:10.1080/01635581.2020.1750662

Cited by 10 publications

(11 citation statements)

References 44 publications

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“…However, regression models were not used then, nor were cut-off points considered for HGS. The authors confirm the importance of using HGS as an auxiliary method in nutritional screening and as a complementary method in the nutritional diagnosis of cancer patients, in addition to the need for further studies [41]. GIT: gastrointestinal tract.…”

Section: Discussionsupporting

confidence: 55%

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Presence of dynapenia and association with anthropometric variables in cancer patients

et al. 2020

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Background Dynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analyze the presence of dynapenia and its association with anthropometric variables in hospitalized cancer patients. Methods Participants comprised adult and elderly cancer patients evaluated within the first 48 h of hospital admission to a tertiary public hospital, a referral center for gastrointestinal tract surgery. Anthropometric variables were measured according to standardized protocols. Dynapenia was identified based on handgrip strength (HGS), according to the cutoff points defined by the European Working Group on Sarcopenia in Older People (EWGSOP2), with values for women < 16 kg and for men < 27 kg. Statistical analysis was performed using SPSS software, version 22.0, with a significance level of 5%. Results This study included 158 patients aged in average 59.5 ± 14.0 years; of these, 53.6% were elderly, 58.9% non-white and 59.5% had some degree of malnutrition. The most prevalent type of cancer was that of the lower gastrointestinal tract (33.5%). The presence of dynapenia was observed in 23.4% of the patients and cachexia in 36.1%. There was an association between dynapenia with age (p < 0.001), life stage (p = 0.002) and race/color (p = 0.027), and also with body mass index (BMI) (p = 0.001) and adductor pollicis muscle thickness (APMT) of both hands (p < 0.05). After logistic regression analysis, adjusted for the sociodemographic variables, the APMT of the dominant hand and the low weight determined by body mass index remained associated with the occurrence of dynapenia (p < 0.05). Conclusions In this study we confirmed that dynapenia was present in cancer patients, being associated with APMT of the dominant hand and low weight. HSG was proven to be a reliable and complementary measure to be added to the process of assessing nutritional status, contributing to the nutritional diagnosis of these patients and to the detection of early muscle depletion.

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Section: Discussionsupporting

confidence: 55%

“…Dynapenia can be diagnosed through the HGS, a measure of functional capacity that complements the nutritional assessment for being associated with malnutrition [39][40][41], in addition to being recommended by the American Society for Parenteral and Enteral Nutrition (ASPEN) for the diagnosis of malnutrition in clinical practice [42].…”

Section: Discussionmentioning

confidence: 99%

Presence of dynapenia and association with anthropometric variables in cancer patients

et al. 2020

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“…The results presented in this study demonstrate an agreement between maximum and mean HGS values in identifying probable sarcopenia in cancer patients. Previous studies have shown no pattern as to the use of these measures at the time of their diagnostic classification [19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Regardless, both maximum HGS [20][21][22]25] and mean HGS [21][22][23][24] present satisfactory outcomes.…”

Section: Discussionmentioning

confidence: 99%

Agreement between maximum and mean handgrip strength measurements in cancer patients

et al. 2022

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Background and aim Handgrip strength (HGS) can be used to identify probable sarcopenia, by measuring maximum strength and/or through the average of three measurements. This study analyzed the agreement between maximum and mean HGS measurements in identifying probable sarcopenia in cancer patients. Methods Adult individuals of both sexes diagnosed with malignant neoplasm were evaluated. HGS (kg/f) was measured in both hands and nutritional status defined by the Patient-Generated Subjective Global Assessment (PG-SGA). Bland-Altman, Intraclass Correlation Coefficient (ICC), and Cronbach’s Alpha tests were applied to assess the agreement between measurements. Results One hundred forty-one patients aged 60.0 ± 14.2 years were evaluated. There was a predominance of elderly (57.4%), male (53.2%), and non-white (58.2%) individuals, with tumors located in the lower gastrointestinal tract (GIT) (36.9%) and with suspected or some degree of malnutrition (61.0%). For men, the Bland-Altman test showed a mean error of 1.37 (95% CI—1.03 to 3.80) for dominant HGS (DHGS) and 1.50 (95% CI—1.60 to 4.60) for non-dominant HGS (NDHGS), while for women the values were 1.34 (95% CI—0.27 to 2.95) and 1.14 (95% CI—1.10 to 3.39), respectively. The ICC showed excellent reproducibility (> 0.90) and the Cronbach’s Alpha was satisfactory (0.99). Conclusion Despite the satisfactory agreement observed between maximum and mean HGS values, in this study, individuals of both sexes with probable sarcopenia were better identified through mean values.

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“…HGS has been proposed as an easy-to-use, noninvasive, objective and inexpensive tool to detect and monitor changes in nutritional status, and to predict functional decline during hospitalization and post-discharge [ 16 , 17 , 18 , 19 ]. HGS correlates with nutritional status and may detect changes in functional capacity in an early stage, before changes in the body composition are manifest [ 20 ]. Therefore, the use of HGS has been advocated by different international guidelines as an important adjunct in the assessment of malnutrition [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength Values Depend on Tumor Entity and Predict 180-Day Mortality in Malnourished Cancer Patients

et al. 2022

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Background: Cancer-related malnutrition is a prevalent condition associated with a loss of muscle mass and impaired functional status, leading to immunodeficiency, impaired quality of life and adverse clinical outcomes. Handgrip strength (HGS) is a practical measure to assess muscle strength in individual patients during clinical practice. However, HGS reference values refer to populations of healthy people, and population-specific values, such as those in the population of cancer patients, still need to be defined. Methods: Within a secondary analysis of a previous randomized controlled nutritional trial focusing on hospitalized cancer patients at risk for malnutrition, we investigated sex-specific HGS values stratified by age and tumor entity. Additionally, we examined the association between HGS and 180-day all-cause mortality. Results: We included data from 628 cancer patients, which were collected from eight hospitals in Switzerland. Depending on the age of patients, HGS varied among female patients from 7 kg to 26 kg and among male patients from 20.5 kg to 44 kg. An incremental decrease in handgrip strength by 10 kg resulted in a 50% increase in 180-day all-cause mortality (odds ratio 1.52 (95%CI 1.19 to 1.94), p = 0.001). Conclusion: Our data provide evidence of the prognostic implications of HGS measurement in cancer patients and validate the prognostic value of handgrip strength in regard to long-term mortality. In addition, our results provide expected HGS values in the population of hospitalized malnourished cancer patients, which may allow better interpretation of values in individual patients.

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The Correlation between Hand Grip Strength and Nutritional Variables in Ambulatory Cancer Patients

Cited by 10 publications

References 44 publications

Presence of dynapenia and association with anthropometric variables in cancer patients

Presence of dynapenia and association with anthropometric variables in cancer patients

Agreement between maximum and mean handgrip strength measurements in cancer patients

Handgrip Strength Values Depend on Tumor Entity and Predict 180-Day Mortality in Malnourished Cancer Patients

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