The Correlation between Functional Connectivity of the Primary Somatosensory Cortex and Cervical Spinal Cord Microstructural Injury in Patients with Cervical Spondylotic Myelopathy

Zhao, Guoshu; Zhang, Chenlei; Zhan, Yaru; He, Laichang

doi:10.1155/2022/2623179

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…After surgery, Cobb's angle of scoliosis (5.10 ± 0.32) and PI-LL (13.92 ± 0.37) in the study group were lower than those before surgery (P < 0.05, Table 3). VAS score [4] 0 is the best, the patient has no pain 1-3 points or less is mild pain that can be tolerated 4-6 points: e pain is more severe, and the patient's sleep is slightly affected 7-10 points are unbearable severe pain, the patient cannot sleep, which seriously affects normal life JOA score [5] Subjective symptoms Clinical signs Limitation of daily activities e total score is 29 points, a higher score represents a better function Quality of life score [6] Cognitive Role Social Physical e total score is 100 points. A higher score represents a better life quality 5).…”

Section: Comparison Of Cobb's Angle Pelvic Projection Angle and Pi-ll...mentioning

confidence: 99%

Feasibility Analysis of 3D Printing-Assisted Pedicle Screw Correction Surgery for Degenerative Scoliosis

Chen

Gao

Zheng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the feasibility of 3D printing-assisted pedicle screw correction surgery for degenerative scoliosis. Methods. From January 1, 2015 to January 31, 2020, patients with degenerative scoliosis who received corrective surgery in our hospital were retrospectively analyzed. Patients were grouped based on the fixation methods. Patients in the control group received traditional pedicle screw internal fixation, while those in the study group received 3D printing-assisted pedicle screw fixation. The therapeutic effects were compared. Results. There were 78 cases in the control group and 82 cases in the study group. There were no significant differences in scoliotic Cobb’s angle, pelvic incidence-lumbar lordosis (PI-LL), VAS score, JOA score, social function, physical function, role function, or cognitive function between the study group and the control group before the surgery, but there were differences in the above parameters between the two groups after surgery. The incidence of postoperative complications in the study group was also significantly lower in the study group. Conclusion. 3D printing-assisted pedicle screw correction surgery provides a strong 3D correction force with reliable effect and fewer complications, and is a good treatment choice for degenerative scoliosis.

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Section: Comparison Of Cobb's Angle Pelvic Projection Angle and Pi-ll...mentioning

confidence: 99%

Feasibility Analysis of 3D Printing-Assisted Pedicle Screw Correction Surgery for Degenerative Scoliosis

Chen

Gao

Zheng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…A recent animal study reported that reduced inflammation in the spinal cord was related to improved neuronal survival in the brain and neurological recovery ( Li et al, 2020 ). In a CSM study, Zhao et al (2022a) found that FA of posterior cervical spinal cord and FC of the somatosensory cortex were relevant. The present study showed that the FA value of FCG was negatively correlated with the paracentral lobule’s zALFF, and FA value of FCC was positively correlated with the caudate zALFF, while CSA of the CST was negatively correlated with the FC between right caudate nucleus and DMN in CSM patients.…”

Section: Discussionmentioning

confidence: 99%

Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy

Wang

Chang

et al. 2023

Front. Neurosci.

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IntroductionCervical spondylotic myelopathy (CSM) is a common form of non-traumatic spinal cord injury (SCI) and usually leads to remodeling of the brain and spinal cord. In CSM with gait instability, the remodeling of the brain and cervical spinal cord is unclear. We attempted to explore the remodeling of these patients’ brains and spinal cords, as well as the relationship between the remodeling of the brain and spinal cord and gait instability.MethodsAccording to the CSM patients’ gait, we divided patients into two groups: normal gait patients (nPT) and abnormal gait patients (aPT). Voxel-wise z-score transformation amplitude of low-frequency fluctuations (zALFF) and resting-state functional connectivity (rs-FC) were performed for estimating brain changes. Cross-sectional area (CSA) and fractional anisotropy (FA) of the spinal cord were computed by Spinal cord toolbox. Correlations of these measures and the modified Japanese Orthopedic Association (mJOA) score were analyzed.ResultsWe found that the zALFF of caudate nucleus in aPT was higher than that in healthy controls (HC) and lower than that in nPT. The zALFF of the right postcentral gyrus and paracentral lobule in HC was higher than those of aPT and nPT. Compared with the nPT, the aPT showed increased functional connectivity between the caudate nucleus and left angular gyrus, bilateral precuneus and bilateral posterior cingulate cortex (PCC), which constitute a vital section of the default mode network (DMN). No significantly different FA values or CSA of spinal tracts at the C2 level were observed between the HC, nPT and aPT groups. In CSM, the right paracentral lobule’s zALFF was negatively correlated with the FA value of fasciculus gracilis (FCG), and the right caudate zALFF was positively correlated with the FA value of the fasciculus cuneatus (FCC). The results showed that the functional connectivity between the right caudate nucleus and DMN was negatively correlated with the CSA of the lateral corticospinal tract (CST).DiscussionThe activation of the caudate nucleus and the strengthening functional connectivity between the caudate nucleus and DMN were associated with gait instability in CSM patients. Correlations between spinal cord and brain function might be related to the clinical symptoms in CSM.

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“…Studies have shown that the ALB value of cerebrospinal fluid is increased in patients with CS. Measuring the ALB value can understand the degree of blood-brain barrier damage in patients [34] ; IL-6, IL-1β, and TNF-α play a role in the early degeneration of cervical discs, and the levels of IL-6, IL-1β, and TNF-α in cervical discs are significantly increased in patients with CS [35,36] ; TP53 is involved in the coordination of multiple cell effects and signal transduction, and inhibition of TP53 can promote the proliferation of human nucleus pulposus cells. [37][38][39] The KEGG function enrichment results showed that the targets were mainly concentrated in the cancer signaling pathway, Kaposi sarcoma-associated herpes virus infection, PI3K-Akt signaling pathway, lipid and atherosclerosis, and human T-cell leukemia type 1 virus infection.…”

Section: Discussionmentioning

confidence: 99%

Study on the mechanism of Shujin Tongluo granules in treating cervical spondylosis based on network pharmacology and molecular docking

et al. 2023

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Background: To investigate the potential active ingredients and possible mechanisms of Shujin Tongluo granules (SJTLG) in the treatment of cervical spondylosis (CS) by network pharmacology and molecular docking. Methods: The active ingredients and potential targets of SJTLG were obtained through databases such as traditional Chinese medicine system (TCMSP) and BATMAN-traditional Chinese medicine (TCM), and the relevant human targets of CS were identified through databases such as OMIM, GeneCards, and DisGeNET. The intersection targets were imported into STRING for protein-protein interaction (PPI) analysis. The obtained data were imported into Cytoscape 3.9.0 software for visualization, and module analysis was performed using the MCODE plug-in. The representative targets were screened through the Metascape website for pathway enrichment analysis in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Cytoscape software was used to build networks such as “drug-compound-target” and “drug-compound-target-pathway.” Finally, the key targets were selected for molecular docking with the corresponding compounds by Autodock Tools 1.5.7 and visualized by PyMol. Results: A total of 132 active compounds and 996 targets from SJTLG and 678 targets from CS were screened with 116 intersection targets. The key targets were AKT1, GAPDH, ALB, IL-6, TP53, TNF, VEGFA, IL-1β, EGFR, HSP90AA1, ESR1, and JUN. The results of GO and KEGG enrichment analysis showed that the treatment of CS was mainly related to biological processes such as cellular response to nitrogen compound, cellular response to organonitrogen compound, and positive regulation of locomotion, and the targets were mainly focused on pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, lipid, and atherosclerosis. Molecular docking results showed that the minimum binding energy between the core targets and the corresponding compound was <−5.0 kcal·mol−1. Conclusion: This study preliminarily elucidates the potential active ingredients and mechanism of anti-inflammatory, analgesic, microcirculation improvement, vasodilation, osteoporosis inhibition and nerve nutrition effects of SJTLG in the treatment of CS and provides a reference for its clinical application.

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The Correlation between Functional Connectivity of the Primary Somatosensory Cortex and Cervical Spinal Cord Microstructural Injury in Patients with Cervical Spondylotic Myelopathy

Cited by 7 publications

References 47 publications

Feasibility Analysis of 3D Printing-Assisted Pedicle Screw Correction Surgery for Degenerative Scoliosis

Feasibility Analysis of 3D Printing-Assisted Pedicle Screw Correction Surgery for Degenerative Scoliosis

Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy

Study on the mechanism of Shujin Tongluo granules in treating cervical spondylosis based on network pharmacology and molecular docking

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