The correlation between fatty liver disease and chronic kidney disease

Chen, Po Chun; Kao, Wei Yu; Cheng, Yuan-Lung; Wang, Yuan Jen; Hou, Ming; Wu, Jaw Ching; Su, Chien–Wei

doi:10.1016/j.jfma.2019.02.010

Cited by 20 publications

(20 citation statements)

References 42 publications

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“…The higher risk of men in this study might be based on lifestyle habit including smoking which is known to be a risk factor of CKD. The severity of NAFLD has been reported to be associated with CKD in several cross-sectional and prospective studies [14,15,[20][21][22]. The results of the current study including those of increases in the FIB-4 index ≥1.30 are consistent with previous studies.…”

Section: Discussionsupporting

confidence: 91%

FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

Seko

Yano

Takahashi

et al. 2019

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes.

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Section: Discussionsupporting

confidence: 91%

FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

Seko

Yano

Takahashi

et al. 2019

IJMS

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“…More than one-third of patients with NAFLD have impaired renal function and impaired renal function in patients with NAFLD is also associated with the severity of liver disease and presence of T2DM. 54,55 When common diseases co-exist and share common risk factors, it can be difficult to disentangle causal relationships and understand the role of potential confounders. T2DM or MetS could be examples of confounding conditions linking NAFLD and CKD.…”

Section: Putative Mechanisms Linking Nafld With Ckd T2dm and Metabolimentioning

confidence: 99%

NAFLD as a driver of chronic kidney disease

Byrne

Targher

2020

Journal of Hepatology

306

263

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Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25-30% (NAFLD), and up to 10-15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD.

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“…Up till now, numbers of studies have explored the relationship between NAFLD and CKD risk in different populations. While numbers of previous studies indicated that the presence of NAFLD was a potential contributory risk factor for the development and progression of CKD, recent studies suggested no adverse association between NAFLD hepatic steatosis and renal function both in general populations and diabetic individuals [19][20][21][22]. Some experts argued that NAFLD itself is not an independent risk factor for CKD, while the comorbidities of NAFLD such as obesity, hypertension, hyperglycemia and hyperuricemia are independently associated with renal dysfunction [23].…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) has attracted much attention, since they share similar risk factors and pathogenic mechanisms, such as insulin resistance (IR), diabetes mellitus (DM), hyperlipidemia and obesity [12][13][14][15][16][17][18]. While numbers of previous studies indicated the presence and severity of NAFLD was a potential contributory risk factor for the development and progression of CKD, recent studies suggested no adverse association between NAFLD hepatic steatosis and renal function both in general populations and diabetic individuals [19][20][21][22]. Some researchers argued that NAFLD itself is not an independent risk factor for CKD, while it is the comorbidities of NAFLD such as obesity, hypertension, and hyperuricemia that are independently associated with CKD [23].…”

Section: Introductionmentioning

confidence: 99%

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

Zhou¹,

Wang²,

Chi³

et al. 2020

Preprint

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Background: Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors, but the specific relationship between NAFLD and gouty nephropathy has not been well understood. We aim to evaluate the association between NAFLD and gouty nephropathy in a non-diabetic gouty population.Methods: The retrospective cross‑sectional study was performed on 1049 non-diabetic gouty participants, who were hospitalized between 2014 and 2020, across 4 districts in Shandong, China. Demographic and clinical characteristics of the study population were collected. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to the NAFLD severity determined by ultrasonography were obtained by multiple logistic regression analysis. Results: An unexpectedly inverse relationship was found between NAFLD severity and the risk of gout nephropathy. Multivariate logistic regression analysis demonstrated that higher degree of NAFLD severity is independently associated with lower risk of gouty nephropathy, after adjusted for age, sex, smoking, gout duration, and metabolic risk factors including obesity, hypertension, hyperglycemia, hyperuriacemia and dyslipidemia, with OR 0.392 (95 % CI 0.248–0.619, P < 0.001), 0.379 (95 % CI 0.233–0.616, P < 0.001) and 0.148 (95 % CI 0.043–0.512, P = 0.003) in participants with mild, moderate, and severe NAFLD, respectively, compared to those without NAFLD. We also observed a weakened association of serum uric acid (SUA) with metabolic risk factors and NAFLD under circumstances of gouty nephropathy (r = -0.054, P = 0.466). Conclusions: The presence and severity of NAFLD was negatively associated with the risk of gouty nephropathy in the non-diabetic gouty populations. Further investigation of NAFLD will provide insights into the pathogenesis of gouty nephropathy.Trials registration: Chinese Clinical Trials Registry ChiCTR2000035185. Registered 2 August 2020.

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The correlation between fatty liver disease and chronic kidney disease

Cited by 20 publications

References 42 publications

FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

NAFLD as a driver of chronic kidney disease

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

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