The Correlation Between Arterial Hypertension and Endothelial Function

Abstract

001arterial bed, as shown by a study performed in hypertensive patients in which abnormal brachial artery FMD was correlated with in vitro maximal response to acetylcholine in subcutaneous small resistance arteries and, on the other hand, FMD was independently related to the impaired small artery vasodilation [7]. Moreover brachial artery FMD correlates with the severity of hypertension: patients with uncontrolled resistant hypertension have, in fact, a greater impairment in endothelial function compared to controlled resistant hypertension ones, and this result is related to non-dipping BP pattern [8]. Furthermore, a study performed in treated hypertensive subjects showed that nocturnal systolic and diastolic BP mainly affected FMD of the brachial artery rather than insulin sensitivity [9].Lower brachial artery FMD was also related to increased risk of CV events during a 95 months-follow-up in 172 uncomplicated hypertensive patients [10].Endothelial dysfunction associated to arterial hypertension shows, however, of being a reversible alteration: six months of antihypertensive therapy improve brachial artery FMD in postmenopausal women and reduce CV events during a mean followup of 67 months compared to women in which FMD did not change during treatment [11]. Among the antihypertensive drugs nebivolol ameliorates vasodilatory response to acetylcholine [12], while reninangiotensin system blockers [13] and combination of perindopril/ indapamide [14] FMD values in hypertensive subjects.Inflammation appears to underlie the link between high blood pressure and endothelial dysfunction. In fact, a systemic inflammatory status induces endothelial dysfunction also in nonhypertensive patients [15], and in addition, circulating levels of C-reactive protein, a marker of inflammation, may independently predict the development of arterial hypertension [16]. Furthermore, also oxidative stress, a well-known determinant of endothelial dysfunction, plays a role in pathogenesis of hypertension through a vicious cycle involving inflammation [17].The severity of endothelial dysfunction is correlated with serum levels of inflammation markers and antioxidant substances also in relatively young subjects affected by essential hypertension [18]. Moreover, in hypertensive patients higher levels of the plasma inflammatory cytokine neopterin are associated with impaired brachial FMD, and, after 3 months of antihypertensive treatment, the decrease in neopterin levels was correlated with the improvement in FMD and the reduction in blood pressure values [19]. As others CV risk factors, hypertension injuries endothelium, EditorialArterial hypertension is defined by a stable increase in systemic arterial blood pressure (BP) values, i.e. systolic value of 140 mmHg or more and/or diastolic one of 90 mmHg or more. Its prevalence is about 30-45% of the general population; representing a well-known cardiovascular (CV) risk factor [1]. In addition to BP values, the assessment of target organ damage has a pivotal role in stratification of total CV risk...