The correlation and role analysis of SLC30A1 and SLC30A10 in cervical carcinoma

Zhang, Jing; Chen, Xinwei; Li-sha, Shu; Liu, Chongdong

doi:10.7150/jca.56777

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…These results suggest the involvement of the zinc-binding, metal-regulatory transcription factor MTF-1, which is activated by the release of zinc from metallothionein (MT) upon metal overload or oxidative stress [31]. Interestingly, the up-regulation of SLC30A1, which encodes a proton-coupled zinc antiporter involved in the efflux of zinc from cells to prevent toxicity, was also observed with increasing exposure duration [32].…”

Section: Discussionmentioning

confidence: 92%

Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells

Stößer,

Lumpp,

Fischer

et al. 2023

IJMS

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Millions of people around the world are exposed to elevated levels of arsenic through food or drinking water. Epidemiological studies have linked chronic arsenic exposure to an increased risk of several cancers, cardiovascular disease, central nervous system neuropathies, and genotoxic as well as immunotoxic effects. In addition to the induction of oxidative stress and inhibition of DNA repair processes, epigenetic effects, including altered DNA methylation patterns resulting in aberrant gene expression, may contribute to carcinogenicity. However, the underlying mechanisms by which chronic micromolar concentrations of arsenite affect the methylation status of DNA are not fully understood. In this study, human HepG2 hepatocarcinoma cells were treated with 0.5–10 μM sodium arsenite for 24 h, 10, or 20 days. During these periods, the effects on global DNA methylation, cell cycle phase distribution, and gene expression were investigated. While no impact on DNA methylation was seen after short-term exposure, global hypomethylation was observed at both long-term exposure periods, with concomitant induction of the DNA methyltransferase genes DNMT1 and DNMT3B, while DNMT3A was slightly down-regulated. Pronounced time- and concentration-dependent effects were also seen in the case of genes involved in DNA damage response and repair, inflammation, oxidative stress response, and metal homeostasis. These results suggest that chronic low-dose arsenite exposure can lead to global hypomethylation. As an underlying mechanism, the consistent down-regulation of DNA methyltransferase genes could be excluded; alternatively, interactions at the protein level could play an important role.

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Section: Discussionmentioning

confidence: 92%

Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells

Stößer,

Lumpp,

Fischer

et al. 2023

IJMS

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Section: Potential Anticancer Studiesmentioning

confidence: 99%

“…From these elucidations, computationally designed derivatives could be obtained by optimizing the biological activity. In 2022, Zhang et al (2022) identified that neopeltolide could inhibit the high expression of the SLC30A10 gene, which belongs to the ZnT gene family that is strongly related to tumor development and metastasis. Despite all the in vitro studies that have demonstrated the high cytotoxic effects of neopeltolide and its derivatives against various cancer cell lines, there is still no in vivo evidence that allows taking the next step towards a clinical evaluation.…”

Section: Complex Bc1mentioning

confidence: 99%

Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents

et al. 2023

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Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica’s north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect.

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A dual-pathway pyroptosis inducer based on Au–Cu2-xSe@ZIF-8 enhances tumor immunotherapy by disrupting the zinc ion homeostasis

Yan,

Chen,

Ren

et al. 2024

Acta Biomaterialia

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The correlation and role analysis of SLC30A1 and SLC30A10 in cervical carcinoma

Cited by 7 publications

References 41 publications

Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells

Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells

Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents

A dual-pathway pyroptosis inducer based on Au–Cu2-xSe@ZIF-8 enhances tumor immunotherapy by disrupting the zinc ion homeostasis

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