The corneal thickness during perfusion of the anterior chamber with solutions of various tonicity

Bahr, Gunnar von

doi:10.1007/bf00146715

Cited by 6 publications

(3 citation statements)

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“…3 This may be the reason that the nature of diurnal changes in tear osmolarity remains unclear and a subject of debate. 25–28 Terry et al reported that the tear film is hypertonic during waking hours and that it is isotonic with the blood serum during sleep. 25 Uniacke et al found that tear osmolarity increased during the day, declined in the evening, and was isotonic with the blood serum during sleep.…”

Section: Discussionmentioning

confidence: 99%

“…These data are consistent with the findings of von Bahr et al; they reported that there were no variations in tear osmolarity that were associated with sleep/wake cycles. 27,28 Dalton et al (Dalton KN, Jones LW. Optom Vis Sci 2005;82:E-abstract 055070) used a novel nanoliter osmometer to evaluate the tear osmolarities of a group of subjects that included both healthy people and dry eye patients.…”

Section: Discussionmentioning

confidence: 99%

“…Optom Vis Sci 2005;82:E-abstract 055070). 25–28 The goal of the present study was to measure the diurnal variations of tear osmolarity and to assess the relationship between tear osmolarity and the volume of the tear meniscus during daytime hours in both healthy subjects and dry eye patients.…”

Section: Introductionmentioning

confidence: 99%

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Daytime Variations of Tear Osmolarity and Tear Meniscus Volume

Zhu

et al. 2012

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives To determine the pattern of variations in tear osmolarity and tear meniscus volume in dry eye patients and in healthy control subjects over an 8-hour daytime period. Methods Ten normal subjects (5 males and 5 females with a mean age of 27 ± 7 yrs) and 10 dry eye patients (4 males and 6 females with a mean age of 36 ± 12 yrs) who had been diagnosed on the basis of having an ocular surface discomfort index (OSDI) >12 and a tear breakup time of < 10 seconds or Schirmer’s test score of < 5 mm were included. The tear meniscus volumes of the participants were measured using ultra-high resolution optical coherence tomography (OCT), and tear osmolarity was measured using the TearLab Osmolarity System. Both measurements protocols were conducted on the right eye of each participant every two hours beginning at 8:30AM and ending at 4:30PM. OCT imaging was performed first and was followed by osmolarity testing. Results The mean tear osmolarity of the dry eye patients was 304.0 ± 10.8 mOsm/L, and the mean tear osmolarity of the normal subjects was 298.0 ±14.2 mOsm/L (P > 0.05). Over the course of 8 hours, the average measured osmolarities of the dry eye group varied by approximately 21.9 ± 13.5 mOsm/L (range, 6–43 mOsm/L), and the average measured tear osmolarities of the normal group varied by approximately 21.0 ± 9.2 mOsm/L (range, 8–35 mOsm/L). At 2:30 PM, the average volume of the tear menisci in the dry eye group was significantly lower than that of the subjects in the normal group (P < 0.05). No correlations between the tear meniscus volumes and tear osmolarities of either group were observed. Conclusions Variations in the tear osmolarities of individual dry eye patients and healthy normal control subjects were documented over the course of 8 daytime hours. No relationships between tear osmolarities and tear meniscus volumes were observed.

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