The coordinative interaction of a diorganotin dihalide with N-(meta-substituted phenyl)-2-hydroxynaphthalideneimine

Organotin(IV) complexes with various donor ligands and their cytotoxicity against tumour cell lines. Part(I): R2SnCl2 with Schiff bases; unusual CN bond cleavage of the bases and X‐ray structures of the ionic products formed

“…The most cytotoxically active compounds among all the compounds studied were the ionic compounds (6)(7)(8) In conclusion, the present results exhibited by the ionic compounds 6-8 against the three cell lines used in the present study are very promising when compared with those of the reference standards. However, it is premature to comment on these preliminary results, as further studies using more cell lines are required to confirm the activity of these ionic compounds.…”

“…The Schiff bases (L1-L5), their Me 2 SnCl 2 complexes (1-5) and the ionic compounds (6)(7)(8) were dissolved in 10% dimethylsulphoxide (DMSO) and further diluted in the medium. The three reference standards of cisplatin, carboplatin and oxaliplatin were used for comparison.…”

“…The free Schiff bases (L1-L5), their Me 2 SnCl 2 complexes (1-5) and the ionic compounds (6)(7)(8) were examined for their cytotoxic activity against the three tumour cell lines L 929 , K 562 and HeLa and the results are summarized in Table 7, together with those of the reference standards (the known anti-cancer drugs, cisplatin, carboplatin and oxaliplatin) for comparison.…”

“…R 2 SnCl 2 ·L, where R = Me, Bu, Ph and L = Schiff base derivatives) and their lymphocyte proliferation activity. 6 Several articles have also been reported on the chemistry and Xray structures of ionic compounds containing the diphenyl tetrachlorostannate anion, i. hydroxybenzalidene)-p-methoxyaniline, 7 6-methylpyridine-2-carboxaldehyde phenylhydrazone, 8 8-methoxyquinoline, 9 8-methylaminoquinoline 10 and thiamine. 11 The present work describes the reaction of 2− , where R = H, (2-aminopyridine); 3-Me, (2-amino-3-methylpyridine) and 4-Me, (2-amino-4-methylpyridine) formed from the unusual cleavage of C N bonds of the Schiff bases (containing a pyridine nucleus) upon their reactions with Ph 2 SnCl 2 only (Fig.…”

New adducts of diorganotin(IV) chlorides with a new multifunctional schiff base ligand: Synthesis and spectral properties

“…The NH protons appear as two broad signals at low field due to intramolecular hydrogen bonding. Broadening of the signal at 10.94 ppm, attributable to the NH proton in the acetylacetone moiety, indicates the weakening of the O-H bond and proton transfer to imine nitrogen atom (tautomeric form III) and, consequently, the interaction of the proton signal with the electric quadrupole moment of nitrogen [15,16].…”