2018
DOI: 10.1111/exd.13677
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The convergence theory for vitiligo: A reappraisal

Abstract: Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding to chemical/radiation exposure, or only by hyperreactive T cells, but rat… Show more

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Cited by 53 publications
(46 citation statements)
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“…Recent reports suggest that autoimmunity predisposes the melanocyte damage in NSV (Furue & Kadono, ; Kemp, Waterman, & Weetman, ; Rezaei, Gavalas, Weetman, & Kemp, ). Recently, a revised convergence theory elucidates the role of the junction of adaptive and innate immune response with other factors in disease pathogenesis (Kundu, Mhlaba, Rangel, & Le Poole, ). Polygenic inheritance of several susceptibility genes has been reported to contribute NSV susceptibility (Spritz & Andersen, ).…”
Section: Introductionmentioning
confidence: 99%
“…Recent reports suggest that autoimmunity predisposes the melanocyte damage in NSV (Furue & Kadono, ; Kemp, Waterman, & Weetman, ; Rezaei, Gavalas, Weetman, & Kemp, ). Recently, a revised convergence theory elucidates the role of the junction of adaptive and innate immune response with other factors in disease pathogenesis (Kundu, Mhlaba, Rangel, & Le Poole, ). Polygenic inheritance of several susceptibility genes has been reported to contribute NSV susceptibility (Spritz & Andersen, ).…”
Section: Introductionmentioning
confidence: 99%
“…Cytotoxic T cells reactive with melanosomal antigens are primarily responsible for progressive melanocyte loss (Strassner and Harris, 2016). The disease can be triggered by different forms of stress, and skin Koebnerization is common, particularly in confetti-like depigmentation (Kundu et al, 2018;Sosa et al, 2015). Thus, stress proteins might mediate cutaneous depigmentation.…”
Section: Introductionmentioning
confidence: 99%
“…The group of Caroline Le Poole, Chicago, IL, USA, reassesses the convergence theory of vitiligo proposed by the lead author more than twenty‐five years ago . The paper underlines that several factors can drive initial melanocyte loss and trigger autoimmune involvement leading to a progressive loss of melanocytes, and emphasizes that it is no longer justify to label vitiligo as a disease of “unknown” aetiology.…”
Section: Vitiligo: Novel Targets For Therapymentioning
confidence: 98%