The conundrum of Thiamine Responsive Acute Pulmonary Hypertension (TRAPH) syndrome in the Emergency Department

Bhat, Ramesh Y; Tirlangi, Praveen; Ravindra, Prithvishree; Balakrishnan, Jayaraj Mymbilly

doi:10.1016/j.ajem.2021.06.015

Cited by 1 publication

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“…A number of case reports have documented WE in women with hyperemesis gravidarum which underlines the significance of thiamine supplementation for pregnant women experiencing protracted vomiting ( 134 , 166 , 241 – 245 ). Thiamine-responsive acute pulmonary hypertension of early infancy and acute life-threatening metabolic acidosis in exclusively breast-fed infants has been reported intermittently from North India, especially Kashmir ( 188 – 190 , 246 ). Another recent study from Kashmir has reported thiamine-responsive neuropathy among peripartum women ( 28 ).…”

Section: Prevalence Of Thiamine Deficiency In Women and Infantsmentioning

confidence: 99%

Thiamine deficiency in pregnancy and lactation: implications and present perspectives

et al. 2023

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During pregnancy, many physiologic changes occur in order to accommodate fetal growth. These changes require an increase in many of the nutritional needs to prevent long-term consequences for both mother and the offspring. One of the main vitamins that are needed throughout the pregnancy is thiamine (vitamin B1) which is a water-soluble vitamin that plays an important role in many metabolic and physiologic processes in the human body. Thiamine deficiency during pregnancy can cause can have many cardiac, neurologic, and psychological effects on the mother. It can also dispose the fetus to gastrointestinal, pulmonological, cardiac, and neurologic conditions. This paper reviews the recently published literature about thiamine and its physiologic roles, thiamine deficiency in pregnancy, its prevalence, its impact on infants and subsequent consequences in them. This review also highlights the knowledge gaps within these topics.

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