The controlling nutritional status score: A promising tool for nutritional screening and predicting severity in ulcerative colitis patients

De-León-Rendón, Jorge L.; López-Pérez, R.Y.; Gracida-Mancilla, Noé I; Jiménez-Bobadilla, Billy; Alarcón-Bernés, Lisbeth; Mendoza-Ramírez, Saulo; Villanueva-Herrero, Juan Antonio

doi:10.1016/j.rgmxen.2020.05.007

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Only J L de-León-Rendón et al showed that patients with a high (>6 points) CONUT score presented with moderate-to-severe activity on the Truelove and Witts scale. [ 18 ] Researchers speculated that the CONUT score could be a promising tool for evaluating nutritional status in UC patients and predicting UC severity. In our study, we showed the lower baseline CONUT scores in patients with positive clinical remission at week 14 (1.00 ± 1.08 vs. 2.16 ± 1.46; p = 0.031).…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status Indicators as a Predictor of Achieving Remission at Week 14 during Vedolizumab Therapy in Patients with Ulcerative Colitis: A Pilot Study

Sobolewska-Włodarczyk

Walecka-Kapica

Włodarczyk

et al. 2023

Nutrients

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Background: The loss of response or failure to achieve remission to vedolizumab in ulcerative colitis (UC) patients is currently a major clinical problem. Recently, Nutritional Risk Index (NRI), Controlling Nutritional Status (CONUT), and Malnutrition Universal Screening Tool (MUST) have been suggested as a new prognostic factor of UC activity. Here, we aimed at confirmation of hypotezis that NRI, CONUT and MUST may be used as inexpensive and efficient predictive biomarkers of response in UC patients treated with vedolizumab. Methods: This study was conducted in retrospective manner in 32 adult patients with UC of Caucasian origin (21 men and 11 women), who were qualified for 52-week therapy with vedolizumab and finished the 14-weeks from January 2020 to March 2022. Our study analyzed the 45 courses of vedolizumab therapy. Nutritional status indicators, i.e., the NRI, CONUT and MUST of each UC patient, were marked at the time of qualifying for biological treatment. Results: In our study, the MUST score was significantly lower in UC patients who positively achieved clinical remission at week 14 during vedolizumab induction therapy (0.33 ± 0.49 vs. 1.37 ± 0.83; p = 0.002). The analysis showed the lower baseline NRI and CONUT scores in patients with positive clinical remission at week 14 (NRI: 96.42 ± 4.29 vs. 101.41 ± 7.09; p = 0.024; CONUT: 1.00 ± 1.08 vs. 2.16 ± 1.46; p = 0.031). Conclusions: Nutritional status indicators (NRI, MUST and CONUT) may become valuable predictor of achieving remission at week 14 during vedolizumab therapy in UC patients.

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Section: Discussionmentioning

confidence: 99%

Nutritional Status Indicators as a Predictor of Achieving Remission at Week 14 during Vedolizumab Therapy in Patients with Ulcerative Colitis: A Pilot Study

Sobolewska-Włodarczyk

Walecka-Kapica

Włodarczyk

et al. 2023

Nutrients

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“…A previous study that investigated the ability of the CONUT score to predict the severity of UC in Mexico, demonstrated that UC patients with a high CONUT score presented with moderate-to-severe activity of disease. 35 However, the characteristics and constitutions of patients in China are different to those in Mexico due to different races and lifestyle habits. Therefore, this current study was undertaken to explore the potential ability of the CONUT score to assess the disease activity of UC patients in China.…”

Section: Discussionmentioning

confidence: 99%

Association with controlling nutritional status score and disease activity of ulcerative colitis

Lian,

Hu,

Cheng

et al. 2023

J Int Med Res

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Objective To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC). Methods This retrospective study enrolled patients with UC. Demographic, clinical and laboratory data were collected and compared. The CONUT score was obtained for each patient. The association between the CONUT score and laboratory parameters was analysed and the ability of the score to assess disease activity was evaluated. Results A total of 182 patients with UC were enrolled. Patients with active disease showed significantly increased inflammatory biomarkers and decreased nutritional biomarkers compared with patients in remission. Malnourished individuals had significantly elevated inflammatory biomarkers and significantly reduced haemoglobin, prealbumin and retinol-binding protein. The CONUT score was inversely correlated with haemoglobin, prealbumin, retinol-binding protein and was positively correlated with faecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. The area under the receiver operating characteristic curve was 0.655 (95% confidence interval, 0.557–0.752). The optimal cut-off value was 1.5 points, with a sensitivity of 75.7% and a specificity of 50.0%. Conclusion The CONUT score may evaluate the inflammatory response and nutritional status of UC patients, so it could be a potential biomarker to assess disease activity in UC.

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“…Body mass index (BMI) = weight (kg)/height (m)^2. The systemic inflammation score (SIS) and controlling nutritional status (CONUT) score were calculated as reported in previous studies (De‐Leon‐Rendon et al, 2021; S. Li et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

Qiu

et al. 2023

Oral Diseases

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ObjectivesTo explore the predictive value of inflammatory‐nutritional score (INS) and a nomogram for survivals in head and neck soft tissue sarcoma (HNSTS) patients with negative resection margins (R0).MethodsClinical characteristics and hematological features of 315 HNSTS patients underwent R0 surgery were analyzed.ResultsThe 5‐year overall survival (OS) rate, 3‐year recurrence‐free survival rate and disease‐free survival (DFS) rate were 77.3%, 61.0% and 55.4%, respectively. High INS was associated with a deep tumor location (p < 0.001), high tumor grade (p < 0.001), and advanced AJCC stage (p < 0.001). The low‐risk group (INS 0) exhibited a higher 5‐year OS rate and 3‐year DFS rate than others (87.6% vs. 81.3% vs. 53.3%, p < 0.001; 62.2% vs. 56.9% vs. 37.9%, p = 0.007). The INS (p = 0.023), tumor depth (p < 0.001), pT classification (p = 0.022), pN classification (p < 0.001) and tumor grade (p < 0.001) were independent survival predictors. Moreover, a novel nomogram for predicting OS was generated and assessed by the concordance index, exhibiting a better performance than the p7TNMG classification alone (p < 0.001).ConclusionsFor R0 resected HNSTS patients, the oncological outcomes can be predicted using the INS system and a specific nomogram.

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The controlling nutritional status score: A promising tool for nutritional screening and predicting severity in ulcerative colitis patients

Cited by 3 publications

References 33 publications

Nutritional Status Indicators as a Predictor of Achieving Remission at Week 14 during Vedolizumab Therapy in Patients with Ulcerative Colitis: A Pilot Study

Nutritional Status Indicators as a Predictor of Achieving Remission at Week 14 during Vedolizumab Therapy in Patients with Ulcerative Colitis: A Pilot Study

Association with controlling nutritional status score and disease activity of ulcerative colitis

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

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