The Control of Circadian Glycogen Rhythms

Sollberger, A.

doi:10.1111/j.1749-6632.1964.tb48204.x

Cited by 44 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These rhythms in glycogen metabolism, along with rhythms in physiology and behavior, are regulated, in part, by a molecular circadian clock that allows organisms/tissues/cells to anticipate and adapt to changes in their environment (3,12). Accordingly, hepatic glycogen levels display diurnal rhythms that persist during fasting (15,20,41). A recent study by Doi et al (10) reported that the diurnal expression of GYS2 is transcriptionally regulated by the core clock component CLOCK (circadian locomotor output cycles kaput).…”

Section: Discussionmentioning

confidence: 95%

Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice

Udoh

Swain

Filiano

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

Chronic ethanol consumption has been shown to significantly decrease hepatic glycogen content; however, the mechanisms responsible for this adverse metabolic effect are unknown. In this study, we examined the impact chronic ethanol consumption has on time-of-day-dependent oscillations (rhythms) in glycogen metabolism processes in the liver. For this, male C57BL/6J mice were fed either a control or ethanol-containing liquid diet for 5 wk, and livers were collected every 4 h for 24 h and analyzed for changes in various genes and proteins involved in hepatic glycogen metabolism. Glycogen displayed a robust diurnal rhythm in the livers of mice fed the control diet, with the peak occurring during the active (dark) period of the day. The diurnal glycogen rhythm was significantly altered in livers of ethanol-fed mice, with the glycogen peak shifted into the inactive (light) period and the overall content of glycogen decreased compared with controls. Chronic ethanol consumption further disrupted diurnal rhythms in gene expression (glycogen synthase 1 and 2, glycogenin, glucokinase, protein targeting to glycogen, and pyruvate kinase), total and phosphorylated glycogen synthase protein, and enzyme activities of glycogen synthase and glycogen phosphorylase, the rate-limiting enzymes of glycogen metabolism. In summary, these results show for the first time that chronic ethanol consumption disrupts diurnal rhythms in hepatic glycogen metabolism at the gene and protein level. Chronic ethanol-induced disruption in these daily rhythms likely contributes to glycogen depletion and disruption of hepatic energy homeostasis, a recognized risk factor in the etiology of alcoholic liver disease.

show abstract

Section: Discussionmentioning

confidence: 95%

Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice

Udoh

Swain

Filiano

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…cycles. The term of diurnal rhythm in liver physiology was used as early as 1927 by Forsgren (7). In the 1950s, the term circadian rhythm was used for fruit flies by Colin Pittendrigh and in humans by Jurgen Aschoff (8).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Circadian Regulation of Gene Expression and Metabolism in the Liver

Guan

Lazar

2022

Semin Liver Dis

View full text Add to dashboard Cite

Circadian rhythms are approximately 24-hour cycles of variation in physiological processes, gene expression, and behavior. They result from the interplay of internal biological clocks with daily environmental rhythms, including light/dark and feeding/fasting. 24-hour rhythms of liver metabolic processes have been known for almost 100 years. Modern studies reveal that, like metabolism, hepatic gene expression is highly rhythmic. Genetic or environmental changes can disrupt the circadian rhythms of the liver, leading to metabolic disorders and hepatocellular carcinoma. In this review, we summarize the current understanding of mechanisms regulating rhythmic gene expression in liver, highlighting the roles of transcription factors that comprise the core clock molecular as well as noncanonical regulators. We emphasize the plasticity of circadian rhythms in the liver as it responds to multiple inputs from the external and internal environments as well as the potential of circadian medicine to impact liver-related diseases.

show abstract

“…Evidence exists that the hepatocyte circadian clock plays an important role in several processes involved in glucose homeostasis, including gluconeogenesis and glycogen turnover. In the latter case, hepatic glycogen levels display a diurnal variation in a variety of species including rats, mice, rabbits, guinea pigs, chickens, and human as highlighted in (Sollberger 1964). Interestingly, time-of-day-dependent rhythms in glycogen levels persist in fasted rodents (albeit at lower amplitude), suggesting that these rhythms are not simply secondary to feeding/fasting cycles (Ishikawa and Shimazu 1976).…”

Section: Circadian Clock Control Of Metabolismmentioning

confidence: 99%

Circadian regulation of metabolism

Bailey

Udoh

Young

2014

Journal of Endocrinology

178

140

View full text Add to dashboard Cite

In association with sleep/wake and fasting/feeding cycles, organisms experience dramatic oscillations in energetic demands and nutrient supply. It is therefore not surprising that various metabolic parameters, ranging from the activity status of molecular energy sensors to circulating nutrient levels, oscillate in time-of-day-dependent manners. It has become increasingly clear that rhythms in metabolic processes are not simply in response to daily environmental/behavioral influences, but are driven in part by cell autonomous circadian clocks. By synchronizing the cell with its environment, clocks modulate a host of metabolic processes in a temporally appropriate manner. The purpose of this article is to review current understanding of the interplay between circadian clocks and metabolism, in addition to the pathophysiologic consequences of disruption of this molecular mechanism, in terms of cardiometabolic disease development.

show abstract

The Control of Circadian Glycogen Rhythms

Cited by 44 publications

References 47 publications

Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice

Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice

Circadian Regulation of Gene Expression and Metabolism in the Liver

Circadian regulation of metabolism

Contact Info

Product

Resources

About