The control of cartilage growth in osteochondrosis: A review

Glade, Michael J.

doi:10.1016/s0737-0806(86)80014-4

Cited by 34 publications

(17 citation statements)

References 197 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…l), in conformity with previous evidence (Glade, 1986) that the occurrence of osteochondrosis in horses is independent of growth rate. Endochondral bone growth and ossification, and growth in height, are less affected by feed restriction than is body-weight gain.…”

Section: Growth In Foalssupporting

confidence: 91%

“…All these diseases are possibly manifestations of one metabolic bone disease in which there is a failure of cartilage to develop into healthy weight-bearing bone (Gabel, 1988). The incidence is thought to be increasing (Glade, 1986), and not only nutrition but heredity, conformation and the extent of exercise have all been considered to play contributory roles. Hintz et al (1976) reproduced a condition not unlike hyperflexion by restricting access of 4-month-old foals to feed and then allowing free access.…”

Section: Growth In Foalsmentioning

confidence: 99%

“…Moreover, high concentrations of insulin can inhibit growth hormone secretion (Phillips, 1986), although this relationship has not been examined in horses. Lack of postprandial synchrony of T4 with insulin is speculated to suppress maturation of growing cartilage and contribute to metabolic bone disease (Glade et al 1984;Glade, 1986;Glade & Luba, 1987). Thus, inadequate supplementary protein and the imposition of meal feeding of foals may contribute to the disease incidence.…”

Section: Growth In Foalsmentioning

confidence: 99%

See 2 more Smart Citations

Nutrition and the growth and racing performance of thoroughbred horses

Frape

1989

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Section: Growth In Foalssupporting

confidence: 91%

Section: Growth In Foalsmentioning

confidence: 99%

Section: Growth In Foalsmentioning

confidence: 99%

See 1 more Smart Citation

Nutrition and the growth and racing performance of thoroughbred horses

Frape

1989

Proc. Nutr. Soc.

View full text Add to dashboard Cite

“…The link between a high energy diet and development of dyschondroplasia is well recognised (Jeffcott 1991;Savage et al 1993), presumably via an endocrine route, for example via thyroid hormone modulation (Glade 1986). The mechanism of such an aetiopathological link remains unclear, and our data suggest that modulation of insulin levels or endocrine IGFs, possibly indirectly through the action of insulin on the serum IGF binding proteins (IGFBPl and 2) (see Rechler 1994 for review) are possible candidates.…”

Section: Discussionmentioning

confidence: 99%

Effects of insulin and insulin‐like growth factors I and II on the growth of equine fetal and neonatal chondrocytes

Henson

Davenport

Butler

et al. 1997

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary The effects of insulin and insulin‐like growth factors (IGFs) I and II on fetal and foal chondrocytes were investigated in vitro. Chondrocytes from the lateral trochlear ridge of the distal femur were obtained from 2 fetuses (280 and 320 days gestation) and one 4‐day‐old foal and cultured. Membrane proteins consistent with type 1 and type 2 IGF receptors were demonstrated by radioligand cross linking and equilibrium binding analysis. It was demonstrated that both IGF‐I and IGF‐II acted as mitogens for isolated equine chondrocytes when present as the sole mitogenic factor in monolayer culture. It was further shown that whereas insulin was able to promote the survival and expansion of cell populations of chondrocytes in culture there was significantly reduced mitogenic stimulation compared to the IGFs. These results suggest that the role of insulin in growth cartilage may be to promote chondrocyte survival, or to suppress differentiation/apoptosis. This supports the hypothesis that relative hyperinsulinaemia may be a contributory factor to equine dyschondroplasia (osteochondrosis). Understanding of contributory, and possibly triggering factors such as this may allow the development of modified methods of husbandry which minimise the risk of disease in populations with a known predisposition.

show abstract

“…However, the effect of copper supplementation of the high energy diets on the incidence of lesions was not tested. An association between energy intake and copper requirements has been proposed by Glade (1986) who suggested that it may be mediated by insulin like growth factor. It is not known what the energy intake of our foals was, but they were well grown compared to Anon (1989) estimations for liveweights at 5 months, and compared with the average daily gains and final live weights of the foals in the study of Hurtig et al (1993), as reported by Burton and Hurtig (1991), suggesting that our foals also received a high energy diet.…”

Section: 7mentioning

confidence: 99%

Effect of copper supplementation on the evidence of developmental orthopaedic disease in pasture‐fed New Zealand Thoroughbreds

Pearce

Firth

Grace

et al. 1998

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary The effect of copper status on the evidence of bone and cartilage lesions was investigated in 21 Thoroughbred foals. The foals and their dams were grazed on pasture containing 4.4–8.6 mg Cu/kg dry matter (DM). Four treatment groups were created by randomly allocating mares and their foals to either copper supplemented (0.5 mg Cu/kg liveweight (LW)/day), or control (pasture only) groups. This experimental design allowed the effect of copper supplementation of mare and foal to be examined independently. Parameters of bone and cartilage development were assessed in the foals both in vivo, and at post mortem at approximately age 150 days. Mare copper supplementation significantly (P<0.01) decreased radiographic indices of physitis in the distal third metatarsal bone of the foals at 150 days, and the prevalence of articular cartilage lesions (P<0.05). Articular cartilage lesions were minor in all foals, with no evidence of clinical developmental orthopaedic disease (DOD) in vivo, with the exception of minor radiographic changes assessed at post mortem. Copper supplementation of the foal had no effect on any of the bone and cartilage parameters. Copper supplementation of the mares did not abolish DOD in the growing foals, emphasising the probable multifactorial nature of this condition. However, mare supplementation may be a useful treatment regime on a farm where the incidence and severity of DOD are of concern.

show abstract

The control of cartilage growth in osteochondrosis: A review

Cited by 34 publications

References 197 publications

Nutrition and the growth and racing performance of thoroughbred horses

Nutrition and the growth and racing performance of thoroughbred horses

Effects of insulin and insulin‐like growth factors I and II on the growth of equine fetal and neonatal chondrocytes

Effect of copper supplementation on the evidence of developmental orthopaedic disease in pasture‐fed New Zealand Thoroughbreds

Contact Info

Product

Resources

About