The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development

Sondalle, Samuel B.; Baserga, Susan J.; Yelick, Pamela C.

doi:10.1177/0022034516651077

Cited by 8 publications

(5 citation statements)

References 59 publications

(111 reference statements)

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“…WDR43 can also robustly bind to promoter-associated noncoding/nascent RNA. [ 11 , 30 ] However, several research studies have examined the molecular role of WDR43 up to this point. [ 14 , 25 ] This study conducted an all-encompassing pan-cancer analysis of WDR43 through the entire TCGA cancers to determine its possible functions and underlying pathways through the incidence, proliferation, and clinical outcomes of distinct tumors.…”

Section: Discussionmentioning

confidence: 99%

WD repeat domain 43 as a new predictive indicator and its connection with tumor immune cell infiltration in pan-cancer

Yang,

Luo,

Liu

et al. 2024

Medicine

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Background: WD repeat domain 43 (WDR43) is a protein component that encodes WD-repeats and is involved in ribosome biogenesis. However, little is known about the role of WDR43 in cancer prognosis and immune modulation. Methods: In this study, we analyzed the expression and prognostic significance of WDR43 in pan-cancer using the Cancer Genome Atlas, the Genotype-Tissue Expression, and the Human Protein Atlas. We also examined the differential expression of WDR43 in liver hepatocellular carcinoma (LIHC) and adjacent tissues of 48 patients using immunohistochemistry. Additionally, we investigated the correlation between WDR43 and clinical characteristics, gene alterations, tumor mutation burden, microsatellite instability, mismatch repair, tumor microenvironment, immune infiltrating cells, and immune-related genes using bioinformatics methods. Gene set enrichment analysis was conducted, and potential biological mechanisms were identified. Results: Immunohistochemistry staining showed that WDR43 was overexpressed in LIHC among 48 patients. Upregulation of WDR43 was associated with unfavorable prognosis, including overall survival in various types of cancer such as LIHC, uterine corpus endometrial cancer, head and neck squamous cell carcinoma, and pancreatic adenocarcinoma. Differential expression of WDR43 was significantly correlated with microsatellite instability, mismatch repair, and immune cell infiltration. Gene ontology annotation analysis revealed that these genes were significantly enriched in immune-related functions, including immune response, immune regulation, and signaling pathways. Conclusion: We conducted a thorough investigation of the clinical features, phases of tumor development, immune infiltration, gene mutation, and functional enrichment analysis of WDR43 in various types of cancer. This research offers valuable insight into the significance and function of WDR43 in clinical therapy.

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Section: Discussionmentioning

confidence: 99%

WD repeat domain 43 as a new predictive indicator and its connection with tumor immune cell infiltration in pan-cancer

Yang,

Luo,

Liu

et al. 2024

Medicine

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“…Ribosome biogenesis is a key means to control total protein synthesis and thereby regulate important functions such as cell growth, proliferation, and differentiation. Temporal regulation of ribosome biogenesis, hence protein translation, coordinates specific developmental events in many tissue types (Chau et al, 2018;Sondalle et al, 2016;Trainor and Merrill, 2014). Recent studies with embryonic stem cell derived cardiomyocytes suggest that downregulation of ribosome biogenesis and global protein synthesis are required for cardiomyocyte maturation (Pereira et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomic Profiling of Murine Embryonic Heart Development Reveals a Role for the Mevalonate Pathway in Cardiomyocyte Proliferation

Edwards

Greco

Miner

et al. 2022

Preprint

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Defining the molecular mechanisms that govern heart development is essential for identifying the etiology of congenital heart disease. Here, quantitative proteomics was used to measure temporal changes in the cardiac proteome at eight critical stages of murine embryonic heart development. Global temporal profiles of the over 7,300 identified proteins uncovered signature cardiac protein interaction networks that linked protein dynamics with molecular pathways. Using this integrated dataset, we identified and established a functional role for the mevalonate pathway in the regulation of embryonic cardiomyocyte proliferation and cell signaling. Overall, our proteomic datasets are an invaluable resource for studying molecular events that regulate embryonic heart development and contribute to congenital heart disease.

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“…The WDR43 protein belongs to the protein family containing the WDR domain. It is usually involved in the assembly of small-subunit processome as a conserved component, and mediates the transcription and processing of small-subunit ribosomal RNA (18S rRNA), which plays a key role in the biogenesis of ribosomes [ 8 , 9 ]. Studies have shown that WDR43 can suspend the release of Pol II and promote transcription extension to regulate the high-level transcription and translation process in the pluripotency of embryonic stem cells [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer

Feng

Zhang

et al. 2021

Cancer Cell Int

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Background WD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain protein family. Its biological function is largely unclear, particularly in colorectal cancer (CRC). Methods In the present study, we searched the TCGA database and found the correlation between WDR43 and CRC. Subsequently, the high expression of WDR43 in human clinical samples of CRC was validated and we further examined the biological functions of it in CRC cells. Finally, we explored potential downstream proteins or pathways and established subcutaneous xenograft model to verify our findings. Results Immunohistochemistry of 16 patient specimens confirmed that the expression of WDR43 was elevated in CRC. WDR43 knockdown was shown to increase apoptosis and inhibit the proliferation, migration and invasion of CRC cells in vitro and reduce tumorigenesis in animal models. In addition, it was found that WDR43 knockdown inhibited vimentin (VIM) expression in CRC cells and overexpression of VIM can partially reverse the effects of WDR43 both in vitro and in vivo. Conclusion In conclusion, the role of WDR43 in the occurrence and development of CRC was investigated in the present study. WDR43 may serve as a valuable biomarker and provide new options for the diagnosis and treatment of colorectal cancer.

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The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development

Cited by 8 publications

References 59 publications

WD repeat domain 43 as a new predictive indicator and its connection with tumor immune cell infiltration in pan-cancer

WD repeat domain 43 as a new predictive indicator and its connection with tumor immune cell infiltration in pan-cancer

Quantitative Proteomic Profiling of Murine Embryonic Heart Development Reveals a Role for the Mevalonate Pathway in Cardiomyocyte Proliferation

WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer

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