The contribution(s) of the insula to speech production: a review of the clinical and functional imaging literature

Ackermann, Hermann; Riecker, Axel

doi:10.1007/s00429-010-0257-x

Cited by 167 publications

(111 citation statements)

References 101 publications

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“…While previous evidence from clinical and neuroimaging studies would support the role of the anterior insula in solely motor speech production (see Ackermann and Riecker, 2010, for a review) our findings would indicate that this region serves a broader function beyond motor speech control, and is in fact a crucial region that mediates language function.…”

Section: Speech Perception and Productionmentioning

confidence: 49%

The role of the insula in speech and language processing

2014

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Lesion and neuroimaging studies indicate that the insula mediates motor aspects of speech production, specifically, articulatory control. Although it has direct connections to Broca's area, the canonical speech production region, the insula is also broadly connected with other speech and language centres, and may play a role in coordinating higher-order cognitive aspects of speech and language production. The extent of the insula's involvement in speech and language processing was assessed using the Activation Likelihood Estimate (ALE) method. Meta-analyses of 42 fMRI studies with healthy adults were performed, comparing insula activation during performance of language (expressive and receptive) and speech (production and perception) tasks. Both tasks activated bilateral anterior insulae. However, speech perception tasks preferentially activated the left dorsal mid-insula, whereas expressive language tasks activated left ventral mid-insula. Results suggest distinct regions of the mid-insula play different roles in speech and language processing.

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Section: Speech Perception and Productionmentioning

confidence: 49%

The role of the insula in speech and language processing

2014

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“…Such hypometabolism was also observed in fMRI studies involving gustatory stimulation [15] and cognitive performance [16]. There are also data indicating reduced amount of HA group gray matter volumes at bilateral insula [6] which points to its reduced functionality among the HA group.…”

Section: Introductionsupporting

confidence: 55%

Role of Controlled Breathing in Adaptation to High Altitude

Siranush¹

2013

AJBIO

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Abstract:Possibilities for adaptation to high altitude conditions by the method of controlled breathing are investigated. It is determined that voluntary reduction in respiratory rate (to 6 per minute) among school students living in highlands improves the heart functioning. It identifies the possibility to correct the disturbances revealed during the investigation through the method of controlled breathing.

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“…Furthermore, multiple cognitive tasks have been shown to engage anticorrelated positive and negative signals (Anderson et al, 2011;Anticevic et al, 2010;Buckner et al, 2008;Fox et al, 2005;Vincent et al, 2008). Although the roles of brain regions with positive BOLD signals are well studied in receptive language processes (Ackermann and Riecker, 2010;Price, 2012;Zekveld et al, 2006), the putative roles of brain regions with negative BOLD signals relative to a resting baseline and the interaction between these regions are not well appreciated.…”

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confidence: 99%

Negative Blood Oxygen Level Dependent Signals During Speech Comprehension

2015

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Speech comprehension studies have generally focused on the isolation and function of regions with positive blood oxygen level dependent (BOLD) signals with respect to a resting baseline. Although regions with negative BOLD signals in comparison to a resting baseline have been reported in language-related tasks, their relationship to regions of positive signals is not fully appreciated. Based on the emerging notion that the negative signals may represent an active function in language tasks, the authors test the hypothesis that negative BOLD signals during receptive language are more associated with comprehension than content-free versions of the same stimuli. Regions associated with comprehension of speech were isolated by comparing responses to passive listening to natural speech to two incomprehensible versions of the same speech: one that was digitally time reversed and one that was muffled by removal of high frequencies. The signal polarity was determined by comparing the BOLD signal during each speech condition to the BOLD signal during a resting baseline. As expected, stimulation-induced positive signals relative to resting baseline were observed in the canonical language areas with varying signal amplitudes for each condition. Negative BOLD responses relative to resting baseline were observed primarily in frontoparietal regions and were specific to the natural speech condition. However, the BOLD signal remained indistinguishable from baseline for the unintelligible speech conditions. Variations in connectivity between brain regions with positive and negative signals were also specifically related to the comprehension of natural speech. These observations of anticorrelated signals related to speech comprehension are consistent with emerging models of cooperative roles represented by BOLD signals of opposite polarity.

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The contribution(s) of the insula to speech production: a review of the clinical and functional imaging literature

Cited by 167 publications

References 101 publications

The role of the insula in speech and language processing

The role of the insula in speech and language processing

Role of Controlled Breathing in Adaptation to High Altitude

Negative Blood Oxygen Level Dependent Signals During Speech Comprehension

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