The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis

Sutton, Saski; Clutterbuck, A.L.; Harris, Pat; Gent, Thomas C.; Freeman, Sarah; Foster, Neil; Barrett‐Jolley, Richard; Mobasheri, Ali

doi:10.1016/j.tvjl.2007.08.013

Cited by 170 publications

(155 citation statements)

References 137 publications

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“…Na osteoartrite são encontrados diversos mediadores pró-inflamatórios catabólicos. Tais mediadores são determinantes no desenvolvimento da doença e compõem um importante método de avaliação do grau de implicação articular (Bertone et al, 2001;Sutton et al, 2009). As interleucinas são responsáveis pelo aumento de prostaglandinas no líquido sinovial.…”

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Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

Yamada

Carvalho

Oliveira

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica [Platelet-rich plasma RESUMOEstudou-se a eficácia do plasma rico em plaquetas (PRP) no tratamento de lesões condrais articulares, experimentalmente induzidas em equinos. Para isso, foi induzida uma lesão condral, na tróclea medial femoral dos dois membros pélvicos de quatro animais. Após 30 dias da indução, as oito articulações foram divididas em dois grupos. Os animais do grupo 1 receberam o tratamento intralesional e intra-articular com PRP, e os do grupo 2 foram tratados apenas com solução fisiológica. As avaliações clínicas, constituídas de exames de claudicação e análises do líquido sinovial, foram realizadas antes da indução da lesão  tempo zero , quinzenalmente, até 120 dias e aos 150 dias. Avaliações macroscópicas, histológicas e histoquímicas foram realizadas no tempo zero e aos 150 dias. Os equinos do grupo 1 apresentaram melhora do grau de claudicação em relação aos do grupo 2. Os exames macroscópicos, histológicos e histoquímicos revelaram melhor tecido de reparação igualmente no grupo 1. Concluiu-se que a administração de PRP apresentou efeitos benéficos no tratamento de lesões condrais experimentais de equinos.Palavras-chave: equino, articulação, artroscopia, plasma rico em plaquetas ABSTRACTThe use of platelet-rich plasma (PRP)

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Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

Yamada

Carvalho

Oliveira

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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“…Die Rolle des subchondralen Knochens rückte in den letzten Jahren in den Fokus, denn ätiopathogenetisch wird zusätzlich eine Versorgungsstörung des Gelenkknorpels von der subchondralen Seite her vermutet (Kawcak et al 2001). Diese Ursachen können Änderungen im Stoffwechsel der Chondrozyten bedingen (Caron 2011), wodurch ein Ungleichgewicht zwischen Zerstörung und Reparatur der extrazellulären Knorpelmatrix (ECM) zugunsten des Knorpelabbaus entsteht (Sutton et al 2009). …”

Section: Introductionunclassified

“…In diesem Prozess gelten zurzeit die proinflammatorischen Zytokine Interleukin-1b (IL-1b) und Tumornekrosefaktor-a (TNF-a), die aus Chondrozyten und Synoviozyten der entzündlich veränderten Synovialmembran freigesetzt werden, als die wichtigsten Entzündungsmediatoren (Martel-Pelletier et al 1999, Sutton et al 2009). Über Rezeptoren auf der Zelloberfläche stimulieren sie die Zellen zu einem katabolen Stoffwechsel (Sutton et al 2009), wodurch vermehrt knorpelabbauende Enzyme wie Matrix-Metalloproteinasen, Kollagenasen und Proteasen, freigesetzt werden (Goldring 2000a).…”

Section: Introductionunclassified

“…Über Rezeptoren auf der Zelloberfläche stimulieren sie die Zellen zu einem katabolen Stoffwechsel (Sutton et al 2009), wodurch vermehrt knorpelabbauende Enzyme wie Matrix-Metalloproteinasen, Kollagenasen und Proteasen, freigesetzt werden (Goldring 2000a). Zusätzlich zu proinflammatorischen Zytokinen werden auch antiinflammatorische Zytokine, wie IL-4, IL-10, IL-13 und Interleukin-1 Rezeptorantagonist (IL-1Ra), in osteoarthritisch veränderten Gelenken gebildet (Arend et al 1998, MartelPelletier et al 1999, Goldring 2000a.…”

Section: Introductionunclassified

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Treatment of Osteoarthritis with ACS (IRAP®) on 26 horses – retrospective study

Warner¹,

Schulze²,

Lischer³

2016

PHK

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The expected clinical results of the treatment with autologous conditioned serum (ACS) used on horses with osteoarthritis (OA) are based mainly on studies from the field of human medicine. These studies documented an effect lasting up to two years after therapy. The aim of the underlying study was to investigate the long-term outcome of horses with OA of the coffin joint that are exclusively treated with ACS. For this purpose, the medical records of horses whose coffin joint was treated with ACS between January 2007 and June 2010 were analysed. X-ray and MRI scans were re-evaluated. The coffin joint was only diagnosed with osteoarthritis if the coffin joint anesthesia reduced lameness by at least 50 % or if the block anesthesia delimited the lameness to the hoof area and the OA was clearly confirmed through diagnostic imaging. The long-term outcome was determined through telephone interviews with the owners. After a period of at least two years following the ACS treatment of the coffin joint, eight out of 26 horses (31%) returned to work at a level equal to or greater than their previous performance level and four (15 %) returned to work at a lower level. In the case of 14 horses (54 %), no long-term treatment success could be observed. No significant correlation between the severity level of the OA and the therapy results could be proven.Keywords: horse / osteoarthritis / coffin joint / diagnostic techniques / medical treatment / ACS / autologous conditioned serum

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“…Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1, play a central role in OA. Activated synoviocytes are one of the main sources of cytokines, and an increase in synoviocytes worsens inflammation of the synovium and other structures of the entire joint [25,28]. Thus, inducing apoptosis of the activated and increased numbers of synoviocytes is thought to be a part of the anti-inflammatory effects that improve osteoarthritic conditions [3].…”

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confidence: 99%

Pro-Apoptotic Effects of Tepoxalin, a Cyclooxygenase/Lipoxygenase Dual Inhibitor, on Canine Synovial Fibroblasts

Sunaga

Hosoya

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Canine osteoarthritis occurs frequently and causes secondary synovitis. Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the major therapeutic options for pain management of joint diseases. Tepoxalin has an unique property as an NSAIDs that suppresses both cyclooxygenase and lipoxygenase. The purpose of this study was to evaluate antiproliferative effects of tepoxalin on cultured canine synovial cells. Cytotoxic effects of tepoxalin, carprofen, meloxicam and AA-861 on cultured canine synoviocytes were evaluated by MTT colorimetric assay. Apoptosis was detected by morphological observations with Giemsa or annexin V/Hoechst 33342 staining and by the inhibition of caspase-3 activity with N-Ac-Asp-Glu-Val-Asp-CHO (Ac-DEVD-CHO). Cytotoxic effects of tepoxalin were evident in comparison with the effects of carprofen or meloxicam. The same tendency of cytotoxicity was observed when 5-lipoxygenase was inhibited by AA-861. The morphological findings and contradictory effects of Ac-DEVD-CHO with regard to the cytotoxicity proved the proapoptotic effects of tepoxalin. In conclusion, tepoxalin might control osteoarthritic synovitis by inducing apoptosis in proliferating synoviocytes, while most NSAIDs that selectively inhibit cyclooxygenase-2 most likely would not suppress synovial proliferation.

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The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis

Cited by 170 publications

References 137 publications

Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

Treatment of Osteoarthritis with ACS (IRAP®) on 26 horses – retrospective study

Pro-Apoptotic Effects of Tepoxalin, a Cyclooxygenase/Lipoxygenase Dual Inhibitor, on Canine Synovial Fibroblasts

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