The contribution of the prefrontal cortex to relevancy-based gating of visual and tactile stimuli

Adams, Meaghan S.; Andrew, Danielle; Staines, Richard

doi:10.1007/s00221-019-05633-9

Cited by 8 publications

(6 citation statements)

References 28 publications

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“…The relevance of a stimulus to the task at hand is a contributor to how the stimulus is processed, with more relevant stimuli eliciting more robust cortical responses. Previous work by our lab demonstrated that the somatosensory-evoked N70 potential is enhanced when the evoking stimulus is task-relevant and attenuated when the evoking stimulus is irrelevant during a sensory grading task (Adams et al, 2017 , 2019 ). When the ability to downregulate cortical excitability to irrelevant distractor stimuli was disrupted using cTBS applied to the prefrontal cortex, these distractors exerted a greater behavioral cost during the sensory grading task (Adams et al, 2019 ).…”

Section: Introductionmentioning

confidence: 88%

“…The present study was designed to investigate how a history of concussion affected the tactile-evoked N70 ERP, which we have shown to be a cortical correlate of task relevance and distractibility in two separate groups of participants (Adams et al, 2017 , 2019 ). The first hypothesis of the present experiment was that relevancy-based sensory gating would be impaired in participants with a history of concussion, resulting in less suppression of N70 cortical responses to task-irrelevant stimuli.…”

Section: Introductionmentioning

confidence: 99%

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A History of Concussion Affects Relevancy-Based Modulation of Cortical Responses to Tactile Stimuli

Adams

Niechwiej-Szwedo

McIlroy

et al. 2020

Front. Integr. Neurosci.

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Modulating cortical excitability based on a stimulus' relevance to the task at hand is a component of sensory gating, and serves to protect higher cortical centers from being overwhelmed with irrelevant information (McIlroy et al., 2003; Kumar et al., 2005; Wasaka et al., 2005). This study examined relevancy-based modulation of cortical excitability, and corresponding behavioral responses, in the face of distracting stimuli in participants with and without a history of concussion (mean age 22 ± 3 SD years; most recent concussion 39.1 ± 30 SD months). Participants were required to make a scaled motor response to the amplitudes of visual and tactile stimuli presented individually or concurrently. Task relevance was manipulated, and stimuli were occasionally presented with irrelevant distractors. Electroencephalography (EEG) and task accuracy data were collected from participants with and without a history of concussion. The somatosensory-evoked N70 event-related potential (ERP) was significantly modulated by task relevance in the control group but not in those with a history of concussion, and there was a significantly greater cost to task accuracy in the concussion history group when relevant stimuli were presented with an irrelevant distractor. This study demonstrated that relevancybased modulation of electrophysiological responses and behavioral correlates of sensory gating differ in people with and without a history of concussion, even after patients were symptom-free and considered recovered from their injuries.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

A History of Concussion Affects Relevancy-Based Modulation of Cortical Responses to Tactile Stimuli

Adams

Niechwiej-Szwedo

McIlroy

et al. 2020

Front. Integr. Neurosci.

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“…To improve the verification performance, we investigated the knowledge of the response to the vibration stimuli and found that the response to the vibration stimuli appeared within approximately 1 s immediately after the stimuli for a short time stimuli [3], [4]. Specifically, when a perceivable oscillatory stimulus was presented, positive to negative potential changes such as P50, N70, P100, and N140 appeared approximately 50 or 100 ms after the stimulus.…”

Section: A Investigation Of Evoked Responses To Vibration Stimulimentioning

confidence: 99%

“…A positive potential change followed by a negative potential change was observed approximately 100 ms after the stimulus as observed in Refs. [3], [4].…”

Section: B Evoked Responses To Perceptible Brief Vibration Stimulimentioning

confidence: 99%

Performance Improvement in User Verification Using Evoked Electroencephalogram by Imperceptible Vibration Stimuli

Nakashima

Shindo

Nakanishi

2021

2021 20th International Symposium on Communications and Information Technologies (ISCIT)

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In this study, we examine electroencephalogram (EEG) biometric information that can be detected continuously with high confidentiality to realize personal verification using the evoked EEG when presented with an imperceptible vibration stimulus. Considering the survey of conventional studies on brainwaves evoked by perceptible vibration stimulation, we determined that to use the evoked EEG, including the immediately response after the stimulus is effective in verification. Therefore, we introduce a method for repeating the stimulus presentation over a short time. In addition, to improve the verification performance, we introduce support vector machine (SVM). Furthermore, we evaluated the verification performance and obtained an equal error rate of 11%.

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“…Further evidence comes from visual attention deficits in neuropsychiatric disorders known to involve dopamine alterations in the brain, such as Parkinson’s disease (Tommasi et al 2015 ; McCoy et al 2020 ) and schizophrenia (Braver et al 1999 ; Keedy et al 2009 ). Next to the neurotransmitter level, there is evidence in humans at the neuroanatomical level for a crucial role of the PFC and a modulating function of the striatum from neurostimulation studies (Adams et al 2019 ; Wang et al 2020 ), lesion studies (Voytek and Knight 2010 ; Wolf et al 2014 ), and functional MRI studies (Anderson et al 2007 ; Parhizi et al 2018 ; Wang et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task

et al. 2022

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Rationale The cognitive control dilemma describes the necessity to balance two antagonistic modes of attention: stability and flexibility. Stability refers to goal-directed thought, feeling, or action and flexibility refers to the complementary ability to adapt to an ever-changing environment. Their balance is thought to be maintained by neurotransmitters such as dopamine, most likely in a U-shaped rather than linear manner. However, in humans, studies on the stability-flexibility balance using a dopaminergic agent and/or measurement of brain dopamine are scarce. Objective The study aimed to investigate the causal involvement of dopamine in the stability-flexibility balance and the nature of this relationship in humans. Methods Distractibility was assessed as the difference in reaction time (RT) between distractor and non-distractor trials in a visual search task. In a randomized, placebo-controlled, double-blind, crossover study, 65 healthy participants performed the task under placebo and a dopamine precursor (L-DOPA). Using 18F-DOPA-PET, dopamine availability in the striatum was examined at baseline to investigate its relationship to the RT distractor effect and to the L-DOPA-induced change of the RT distractor effect. Results There was a pronounced RT distractor effect in the placebo session that increased under L-DOPA. Neither the RT distractor effect in the placebo session nor the magnitude of its L-DOPA-induced increase were related to baseline striatal dopamine. Conclusions L-DOPA administration shifted the stability-flexibility balance towards attentional capture by distractors, suggesting causal involvement of dopamine. This finding is consistent with current theories of prefrontal cortex dopamine function. Current data can neither confirm nor falsify the inverted U-shaped function hypothesis with regard to cognitive control.

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The contribution of the prefrontal cortex to relevancy-based gating of visual and tactile stimuli

Cited by 8 publications

References 28 publications

A History of Concussion Affects Relevancy-Based Modulation of Cortical Responses to Tactile Stimuli

A History of Concussion Affects Relevancy-Based Modulation of Cortical Responses to Tactile Stimuli

Performance Improvement in User Verification Using Evoked Electroencephalogram by Imperceptible Vibration Stimuli

L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task

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