The Contribution of Strains and Hosts to Outcomes in Clostridium difficile Infection

Martin, Jessica

doi:10.1016/j.idc.2014.11.012

Cited by 11 publications

(4 citation statements)

References 41 publications

(73 reference statements)

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“…Thus, C. difficile is a frequent component of the faecal microbiota of newborn infants not causing disease [38]. Clostridium difficile colonisation in children is common but severe infection and death are much less frequent than in adults [39]. This might be explained by the fact that in infants the microbiota is insufficiently developed and colonisation resistance is not yet established [40,41].…”

Section: Colonisationmentioning

confidence: 99%

“…1). Toxin production and secretion increases after vegetative cells enter into the stationary growth phase [33,39]. …”

Section: Pathogenesis Of Clostridium Difficile Infectionmentioning

confidence: 99%

“…(A) Intoxication of host epithelial cells by C. difficile toxins produced by vegetative cells is primary to inflammatory response. Toxin production and secretion increases after vegetative cells enter into the stationary growth phase [22,39]. During cell infection, the toxins are subjects to time-dependent degradation due to proteolysis and pH effects.…”

Section: Figmentioning

confidence: 99%

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Host response to Clostridium difficile infection: Diagnostics and detection

Usacheva

Jin

Peterson

2016

Journal of Global Antimicrobial Resistance

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Clostridium difficile infection (CDI) is a significant healthcare concern worldwide, and C. difficile is recognised as the most frequent aetiological agent of infectious healthcare-associated diarrhoea in hospitalised adult patients. The clinical manifestation of CDI varies from self-limited diarrhoea to life-threatening colitis. Such a broad disease spectrum can be explained by the impact of host factors. Currently, a complex CDI aetiology is widely accepted, acknowledging the interaction between bacteria and the host. Clostridium difficile strains producing clostridial toxins A and B are considered toxigenic and can cause disease; those not producing the toxins are non-pathogenic. A person colonised with a toxigenic strain will not necessarily develop CDI. It is imperative to recognise patients with active disease from those only colonised with this pathogen and to implement appropriate treatment. This can be achieved by diagnostics that rely on host factors specific to CDI. This review will focus on major aspects of CDI pathogenesis and molecular mechanisms, describing host factors in disease progression and assessment of the host response in order to facilitate the development of CDI-specific diagnostics.

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Section: Colonisationmentioning

confidence: 99%

“…1). Toxin production and secretion increases after vegetative cells enter into the stationary growth phase [33,39]. …”

Section: Pathogenesis Of Clostridium Difficile Infectionmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

See 1 more Smart Citation

Host response to Clostridium difficile infection: Diagnostics and detection

Usacheva

Jin

Peterson

2016

Journal of Global Antimicrobial Resistance

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“…Durch das zunehmende Auftreten hochvirulenter Stämme, z. B. dem Ribotyp 027, wird sich die klinische Problematik weiter verschärfen [8,9]. Der erste Ausbruch durch den Ribotyp 027 im September 2007 wurde in Rheinland-Pfalz beschrieben [10]…”

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