“…Computational multi-scale and large-scale modeling are increasingly used to gain insights on brain functions and dysfunctions (Dyhrfjeld-Johnsen et al, 2007 ; Bouteiller et al, 2011 ; Hendrickson et al, 2013 ; Mattioni and Le Novère, 2013 ; Dougherty et al, 2014 ; Yu et al, 2014 ). At the synaptic level, a large number of receptors, mechanisms, and pathways modulate synaptic strength, function, and plasticity.…”