The Contribution of New Mutations to Genotype-Environment Interaction for Fitness in Drosophila melanogaster

Fry, James D.; Heinsohn, Stefanie L.; Mackay, Trudy F. C.

doi:10.2307/2410700

Cited by 59 publications

(75 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A2). This finding is corroborated by studies looking at mutational variance in flies, where both high (Fernandez and Lopez-Fanjul 1997) and low (Fry et al 1996) temperatures have been shown to increase variance relative to standard laboratory temperatures. In light of current concerns about global climate change, this observation poses an interesting question-to what extent can the release of expressed mutational variance by changing temperature mitigate the negative biological consequences of global climate change?…”

Section: Discussionsupporting

confidence: 53%

“…For example, traits with complex genetic architectures have more mutational targets and may display either more variability because of mutation (Houle et al 1996) or greater robustness to mutations (de Visser et al 2003) than do traits with simple genetic architectures. The environment in which a mutation occurs can also influence how strong an effect that mutation has on a phenotype (e.g., Fry et al 1996;Vassilieva et al 2000;Baer 2008). Characterizing the effects of mutation across trait types and environments can deepen our understanding of the evolutionary process.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Phenotypic Effects of Spontaneous Mutations in Different Environments

Latta

Peacock

Civitello

et al. 2015

The American Naturalist

View full text Add to dashboard Cite

Understanding the context dependence of mutation represents the current frontier of mutation research. In particular, understanding how traits vary in their abilities to accrue mutational variation and how the environment influences expression of mutant phenotypes yields insight into evolutionary processes. We conducted phenotypic assays in four environments using a set of Daphnia pulex mutation accumulation lines to examine the context dependence of mutation. Life-history traits accrued mutational variance faster than morphological traits when considered in individual environments. Across environments, the mutational variance in plasticity was also greater for life-history traits than for morphological traits, although this pattern was less robust. In addition, the expression of mutational variance depended on the environment, which resulted in changes in the rank order of genotype performance across environments in some cases. Such cryptic genetic variation resulting from mutation may maintain genetic diversity and allow for rapid adaptation in spatially or temporally variable environments.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

The Phenotypic Effects of Spontaneous Mutations in Different Environments

Latta

Peacock

Civitello

et al. 2015

The American Naturalist

View full text Add to dashboard Cite

show abstract

“…Recently, an alternative mechanism has been proposed to account for the evolution of crossing reaction norms. Fry et al (1996) have pointed out that a steady influx of spontaneous mutations that are generally mildly deleterious but that differ among environments in the severity of their effects would also generate crossing reaction norms (see Fig. 1 of Fry et al 1996).…”

mentioning

confidence: 99%

“…Fry et al (1996) have pointed out that a steady influx of spontaneous mutations that are generally mildly deleterious but that differ among environments in the severity of their effects would also generate crossing reaction norms (see Fig. 1 of Fry et al 1996). Such mutations are expected to persist if their effects on fitness, particularly in the most common environment, are slight.…”

mentioning

confidence: 99%

The Contribution of Spontaneous Mutation to Variation in Environmental Response in Arabidopsis Thaliana: Responses to Nutrients

Chang¹,

Shaw²

2003

Evolution

View full text Add to dashboard Cite

Although the evolutionary importance of spontaneous mutation is evident, its contribution to the evolution of ecological specificity remains unclear, because the environmental sensitivity of effects of new mutations has received little empirical attention. To address this issue, we report a greenhouse in which we grew plants from 20 mutation-accumulation (MA) lines, advanced by selfing and single-seed descent from a single common founder to generation 17, as well as plants from five lines representing the founder, in high and low nutrient conditions. We examined 11 traits throughout life history, including germination, survivorship, bolting date, flowering date, leaf number, leaf size, early and late height, mean fruit size, total seed weight, and reproductive biomass. Comparison of trait means between the two generations did not support the commonly held view that new mutations affecting fitness in these MA lines are strongly biased toward deleterious effects. We detected significant variance among MA lines for one fitness component, mean fruit size, but we did not detect a significant contribution of mutations accumulated in these MA lines to genotype by environment interaction (GEI). These results suggest that other evolutionary mechanisms play a more important role than spontaneous mutation alone in establishing the GEI found for wild collections and lab accessions of Arabidopsis thaliana in previous studies.

show abstract

“…To date, most QTL analyses have focused on basic issues of genetic architecture: how many QTL influence particular traits, where they are located, and what is the magnitude and type of their effects on the traits of interest (Tanksley, 1993;Liu, 1997;Paterson, 1997). When different environments have been considered, interest has largely centered on the extent of variation in expression of QTL among environments, measured as QTL · environment interactions (e.g., Fry et al, 1996;Juenger et al, this volume). In contrast, the role of QTL in genetic correlations among traits has received relatively little attention.…”

Section: Introductionmentioning

confidence: 99%

Back to the future: genetic correlations, adaptation and speciation

Via

Hawthorne

2005

Genetica

View full text Add to dashboard Cite

Genetic correlations can affect the course of phenotypic evolution. Although genetic correlations among traits are a common feature of quantitative genetic analyses, they have played a very minor role in recent linkage-map based analyses of the genetic architecture of quantitative traits. Here, we use our work on host-associated races in pea aphids to illustrate how quantitative trait locus (QTL) mapping can be used to test specific hypotheses about how genetic correlations may facilitate ecological specialization and speciation.

show abstract

The Contribution of New Mutations to Genotype-Environment Interaction for Fitness in Drosophila melanogaster

Cited by 59 publications

References 0 publications

The Phenotypic Effects of Spontaneous Mutations in Different Environments

The Phenotypic Effects of Spontaneous Mutations in Different Environments

The Contribution of Spontaneous Mutation to Variation in Environmental Response in Arabidopsis Thaliana: Responses to Nutrients

Back to the future: genetic correlations, adaptation and speciation

Contact Info

Product

Resources

About