“…Consistently, C. elegans models carrying gain/loss of function mutations of genes involved in neurodegenerative diseases have been generated, recapitulating many of the characteristics of the disease at the cellular level [210,211]. These models provide interesting possibilities for the study of disease mechanisms.…”
Section: Ca 2+ Imaging In Caenorhabditis Elegansmentioning
Calcium (Ca2+) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic transmission and neuronal plasticity are regulated by Ca2+, and neuronal survival itself relies on Ca2+-dependent cascades. Indeed, impaired Ca2+ homeostasis has been reported in aging as well as in the onset and progression of neurodegeneration. Understanding the physiology of brain function and the key processes leading to its derangement is a core challenge for neuroscience. In this context, Ca2+ imaging represents a powerful tool, effectively fostered by the continuous amelioration of Ca2+ sensors in parallel with the improvement of imaging instrumentation. In this review, we explore the potentiality of the most used animal models employed for Ca2+ imaging, highlighting their application in brain research to explore the pathogenesis of neurodegenerative diseases.
“…Consistently, C. elegans models carrying gain/loss of function mutations of genes involved in neurodegenerative diseases have been generated, recapitulating many of the characteristics of the disease at the cellular level [210,211]. These models provide interesting possibilities for the study of disease mechanisms.…”
Section: Ca 2+ Imaging In Caenorhabditis Elegansmentioning
Calcium (Ca2+) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic transmission and neuronal plasticity are regulated by Ca2+, and neuronal survival itself relies on Ca2+-dependent cascades. Indeed, impaired Ca2+ homeostasis has been reported in aging as well as in the onset and progression of neurodegeneration. Understanding the physiology of brain function and the key processes leading to its derangement is a core challenge for neuroscience. In this context, Ca2+ imaging represents a powerful tool, effectively fostered by the continuous amelioration of Ca2+ sensors in parallel with the improvement of imaging instrumentation. In this review, we explore the potentiality of the most used animal models employed for Ca2+ imaging, highlighting their application in brain research to explore the pathogenesis of neurodegenerative diseases.
“…The profound influence of neuromodulators on behavior, metabolism, and overall physiology is a common thread throughout this issue (Cheon, Hwang, & Kim, 2020;Honer et al, 2020;Kim & Flavell, 2020;Kim, Lee, Kim, & Lee, 2020;Liang, McKinnon, & Rankin, 2020;Liu & Zhang, 2020;Muirhead & Srinivasan, 2020;Prahlad, 2020;Srinivasan, 2020;Takeishi, Takagaki, & Kuhara, 2020;Yang, Lee, Yim, & Lee, 2020). In this perspective, we will focus on the roles of monoamines and neuropeptides in C. elegans survival.…”
Section: A Common Thread Throughout This Issuementioning
confidence: 99%
“…As in mammalian neurodegenerative models, C. elegans DA neurons appear more susceptible to degeneration upon expression of disease-associated aggregation-prone proteins, such as a-synuclein (Mor et al, 2017). In this collection, the Rankin lab focuses on how C. elegans serves as a powerful model in which to study neurodegeneration (Liang, McKinnon, & Rankin, 2020).…”
Section: Monoamine Modulatorsmentioning
confidence: 99%
“…For example, there are ILPs that sometimes behave like the DAF-2 receptor in one context and opposite from DAF-2 in another context (Fernandes de Abreu et al, 2014). The articles in this collection discuss the roles of ILPs in temperature-sensing (see Takeishi, Takagaki, & Kuhara, 2020), in context-dependent avoidance behaviors (see Cheon, Hwang, & Kim, 2020;Kim & Flavell, 2020), in neuroprotection (see Liang, McKinnon, & Rankin, 2020), the dauer program (see Yang et al, 2020), and longevity (see .…”
Section: Neuropeptidesmentioning
confidence: 99%
“…Indeed, numerous studies in mammalian systems implicate neuromodulator dysfunction in neurodegenerative diseases, such as Alzheimer's disease, Huntington's disease and Parkinson's disease, where impaired neuromodulator signaling often preempt disease symptoms (Du, Pang, & Hannan, 2013;Elsworthy & Aldred, 2019;Ohno, Shimizu, Tokudome, Kunisawa, & Sasa, 2015;Politis & Niccolini, 2015). Caenorhabditis elegans expresses many orthologs of neurodegenerative disease-associated genes and their study in the worm have contributed to our understanding of the above human diseases (see Liang, McKinnon, & Rankin, 2020;this issue). Understanding the role of neuromodulators in worm neurodegeneration will likely add to our understanding of human neurodegenerative disorders.…”
The coordination between the animal's external environment and internal state requires constant modulation by chemicals known as neuromodulators. Neuromodulators, such as biogenic amines, neuropeptides and cytokines, promote organismal homeostasis. Over the past several decades, Caenorhabditis elegans has grown into a powerful model organism that allows the elucidation of the mechanisms of action of neuromodulators that are conserved across species. In this perspective, we highlight a collection of articles in this issue that describe how neuromodulators optimize C. elegans survival.
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