The contribution of hepatic metabolism to diet-induced thermogenesis

Berry, Michael N.; Clark, Dallas G.; Grivell, Anthony R.; Wallace, Patricia G.

doi:10.1016/0026-0495(85)90123-4

Cited by 66 publications

(23 citation statements)

References 31 publications

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“…Such ability to overcome excessive energy intake may be related to rat ability to dissipate excess energy as heat. It is particularly true for young rats that resist becoming obese when fed a cafeteria-diet by increasing energy expenditure [33] through thermogenic processes occurring in liver [34] and BAT [35]. Our results show that, in rats fed a high fat diet, the ability of the liver to oxidize fatty acid, as assessed by i) ketone body formation, and ii) hepatocyte and mitochondrial respiration, is not enhanced.…”

Section: Discussionmentioning

confidence: 81%

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Romestaing

Piquet²,

Bedu

et al. 2007

Nutr Metab (Lond)

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Section: Discussionmentioning

confidence: 81%

Untitled

Romestaing

Piquet²,

Bedu

et al. 2007

Nutr Metab (Lond)

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“…Although direct studies of splanchnic oxygen consumption showed no consistent change after glucose administration (52,53), Berry et al (54) recently suggested that the liver plays a significant role in diet-induced thermogenesis. The consistently higher specific activity in arterial than in venous plasma water (Fig.…”

Section: Discussionmentioning

confidence: 98%

Influence of Aging on Hepatic and Peripheral Glucose Metabolism in Humans

Jackson

Hawa²,

Roshania³

et al. 1988

Diabetes

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Mechanisms of glucose intolerance with aging were studied by comparing the metabolic response to glucose ingestion in 10 young (20-23 yr) and 10 elderly (73-80 yr) normal men with the simultaneous application of the forearm and double-isotope techniques. The latter technique consisted of a primed-constant infusion of [3-3H]glucose followed by the administration of an oral glucose load (mean +/- SE, 90.7 +/- 0.7 g) containing [1-14C]glucose. Fasting plasma glucose and insulin concentrations were similar in young and elderly subjects, but in the elderly, glucose tolerance was markedly impaired. Although in the elderly the initial rise in insulin levels (delta, i.e., the incremental area under the curve) from 0 to 30 min was delayed (P less than .02), the response from 0 to 45 min, 0 to 60 min, and thereafter equaled that in the young group, and from 90 to 240 min insulin concentrations in the elderly exceeded those in young subjects. Basal hepatic glucose output (HGO) was similar in young and elderly men (2.13 +/- 0.10 and 1.97 +/- 0.14 mg.kg-1.min-1, respectively). Similar proportional reductions in HGO from 0 to 270 min after glucose loading occurred in young (59.7 +/- 10.3%) and elderly (50.3 +/- 4.9%) subjects but was delayed in the elderly. Suppression of HGO was observed in the young 30 min after glucose ingestion (P less than .02), but not before 60 min in the elderly subjects (P less than .05). The systemic appearance of ingested glucose (0-270 min) was slowed with age (80.7 +/- 3.1 and 66.9 +/- 4.3% of the oral load in the young and elderly groups, respectively; P less than .02). Initial increments in both total glucose disappearance (Rd) and forearm glucose uptake (FGU) from 0 to 60 min after glucose loading were decreased in the elderly (Rd, 4.1 +/- 0.7 vs. 11.5 +/- 1.3 g, P less than .001; FGU, 17.2 +/- 1.4 vs. 24.6 +/- 2.5 md/dl forearm, P less than .02). The overall increment (delta, 0-270 min) in Rd was reduced with age (47.2 +/- 2.9 and 34.5 +/- 3.6 g, P less than .02 in the young and elderly, respectively), but the corresponding data for FGU were similar in the two groups.(ABSTRACT TRUNCATED AT 400 WORDS)

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“…The site of regulatory thermogenesis in the mammal has been placed by most authors on the brown adipose tissue (Rothwell & Stock, 1979b;Girardier, 1983), or in liver (Berry, Clark, Grivell & Wallace, 1985;Ma, Nadeau & Foster, 1987), as well as in muscle for shivering thermogenesis (Hemingway, 1963;Jansky & Hart, 1963).…”

Section: Introductionmentioning

confidence: 99%

Short‐term oscillations of aortic core temperature and thermogenic organ blood flow in the rat

Closa

Gómez-Sierra²,

Latres³

et al. 1993

Experimental Physiology

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SUMMARYCore and organ temperatures in the rat have been found to be subject to regular periodic oscillations (with a frequency of ca 12 cycles per day, i.e. 143 ,tHz) within set limits, by using a chronic thermocouple implant procedure. These cycles consisted of consecutive warming (the temperature increased steadily) and cooling periods (the temperature decreased regularly).There were sustained temperature differences between several tissues and that of the aortic blood (core temperature), higher for brown adipose tissue, kidney and liver, and lower for muscle, white adipose tissue and skin. Organ blood flows and cardiac output were measured by a radioactive microsphere retention method applied to unanaesthetized rats. Blood flow measurements were done on unaware rats (see Methods), during either the warming or cooling phases. During the warming phases, there was a higher blood flow across the brown adipose tissue, kidneys and skin, with a cardiac output about twice that found in the cooling periods. The haemodynamic changes observed, as well as the organ temperature differences observed with respect to the blood, suggest that periodic changes in blood flow are an essential part of the operation of the thermogenic system.

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The contribution of hepatic metabolism to diet-induced thermogenesis

Cited by 66 publications

References 31 publications

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Influence of Aging on Hepatic and Peripheral Glucose Metabolism in Humans

Short‐term oscillations of aortic core temperature and thermogenic organ blood flow in the rat

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