The contribution of fetal MR imaging to the assessment of oesophageal atresia

Hochart, Véronique; Verpillat, P.; Langlois, Carole; Garabédian, Charles; Bigot, Julien; Debarge, V.; Sfeir, Rony; Avni, Fred E.

doi:10.1007/s00330-014-3444-y

Cited by 38 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More recently, the role of fetal magnetic resonance imaging (MRI) and amniotic fluid (AF) analysis in the diagnosis of EA has been investigated as a potential tool to increase prenatal detection. Gamma‐glutamyl transpeptidase (GGTP) is an AF digestive enzyme, secreted by microvilli.…”

Section: Introductionmentioning

confidence: 99%

Prenatal detection of esophageal atresia: A systematic review and meta‐analysis

Pardy

D’Antonio

Khalil

et al. 2019

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction:The primary aim of this systematic review was to quantify the diagnostic performance of ultrasound, magnetic resonance imaging and amniotic fluid analysis in detecting esophageal atresia prenatally. The secondary aim was to explore the accuracy of individual imaging signs in identifying this anomaly.Material and methods: MEDLINE, Embase and Cochrane databases were searched.The quality of studies was assessed using the revised tool for the quality assessment of diagnostic accuracy studies. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio for the predictive accuracy of ultrasound, magnetic resonance imaging and amniotic fluid analysis in detecting esophageal atresia were computed using the hierarchical summary receiver operating characteristic or DerSimonian-Laird random-effect model, according to the number of studies included in each analysis. PROSPERO registration number: CRD42017055828.Results: Twenty studies (73 246 fetuses, 1760 affected by esophageal atresia) were included. Overall, prenatal ultrasound had a sensitivity of 31.7%. Only two studies reported all data for diagnostic accuracy; based on these studies, prenatal ultrasound had a sensitivity of 41.9%, a specificity of 99.9%, a positive likelihood ratio of 88.1, a negative likelihood ratio of 0.58 and a diagnostic odds ratio of 153.7. Prenatal ultrasound correctly identified 77.9% of cases with esophageal atresia and 21.9% esophageal atresia with an associated tracheo-esophageal fistula. Polyhydramnios was present in 56.3% of cases affected by esophageal atresia, and a small or absent stomach was identified in 50.0% cases. When performed following a suspicious ultrasound, fetal magnetic resonance imaging had an good overall diagnostic accuracy for esophageal atresia, with a sensitivity of 94.7%, a specificity of 89.3%, a positive likelihood ratio of 8.8, a negative likelihood ratio of 0.06 and a diagnostic odds ratio of 149.3. Finally, amniotic fluid analysis with an esophageal atresia index ≥3 had a sensitivity of 89.9% and a specificity of 99.6% in detecting esophageal atresia. Conclusions:Ultrasound alone is a poor diagnostic tool for identifying esophageal atresia prenatally, and has a high rate of false positive diagnoses. Magnetic resonance imaging and amniotic fluid analysis have high diagnostic accuracy for esophageal atresia. We would recommend their use following a suspicious ultrasound.

show abstract

Section: Introductionmentioning

confidence: 99%

Prenatal detection of esophageal atresia: A systematic review and meta‐analysis

Pardy

D’Antonio

Khalil

et al. 2019

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…The value of ultrasound, MRI, and biochemistry of the amniotic fluid in the prenatal diagnosis of EA has already been evaluated in prenatal series, which are usually in selected population, but rarely from postnatal series . In this pragmatic study, we investigated the performance of prenatal diagnosis of EA from a postnatal cohort of infants managed in the pediatric/neonatal intensive care unit.…”

Section: Introductionmentioning

confidence: 99%

“…12,14,15 The value of ultrasound, MRI, and biochemistry of the amniotic fluid in the prenatal diagnosis of EA has already been evaluated in prenatal series, which are usually in selected population, but rarely from postnatal series. 14,16,17 In this pragmatic study, we investigated the performance of prenatal diagnosis of EA from a postnatal cohort of infants managed in the pediatric/neonatal intensive care unit. We evaluated the relevance of ultrasound in the prenatal detection of EA and of associated anomalies, and we also evaluated the performance of second-line tools such as MRI and biochemistry of the amniotic fluid.…”

Section: Introductionmentioning

confidence: 99%

Performance of prenatal diagnosis in esophageal atresia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Polyhydramnios and empty or small stomach can help to make the diagnosis of EA, but they occur only between a third and half of cases [13]. Visualisation of dilated, blind-ending, fluid filled proximal oesophagus (oesophageal pouch) is crucial [14][15][16]. Nevertheless, prenatal diagnosis of EA remains a challenge [13,17].…”

Section: Abdominal and Pelvic Abnormalitiesmentioning

confidence: 99%

Postnatal verification of prenatal diagnoses established on foetal magnetic resonance imaging

Duczkowska¹,

Olwert

Duczkowski³

et al. 2018

Ginekol Pol

View full text Add to dashboard Cite

High correlation of prenatal and postnatal tests' results in the study material confirms the high value of foetal MRI in perinatal diagnostics. Comprehensive assessment of the foetus in prenatal MRI is very effective and facilitates impor-tant therapeutic decisions in the prenatal period (in utero treatment) and in perinatal care (application or withdrawal from the EXIT procedure, surgery or backtracking from neonatal resuscitation if it should bear the hallmarks of persistent therapy).

show abstract

The contribution of fetal MR imaging to the assessment of oesophageal atresia

Cited by 38 publications

References 37 publications

Prenatal detection of esophageal atresia: A systematic review and meta‐analysis

Prenatal detection of esophageal atresia: A systematic review and meta‐analysis

Performance of prenatal diagnosis in esophageal atresia

Postnatal verification of prenatal diagnoses established on foetal magnetic resonance imaging

Contact Info

Product

Resources

About