The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

Browning, Matthew G.; Evans, Ronald K.

doi:10.1515/ijamh-2014-0036

Cited by 17 publications

(11 citation statements)

References 52 publications

(77 reference statements)

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“…FM had not changed during all periods, and FFM showed similar changes as REE. This result supported that FFM is the largest contributor to REE. We have shown that FFM was not significantly different between preconception and a few weeks after delivery, whereas Berggren et al .…”

Section: Discussionsupporting

confidence: 85%

Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes

Eto

Maki

Tamada

et al. 2018

J of Diabetes Invest

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Aims/IntroductionTo measure longitudinal changes in resting energy expenditure and body composition of Japanese pregnant women with or without diabetes.Materials and MethodsThe study population consisted of women who had delivered a live singleton neonate after 22 weeks’ gestation at Okayama University Hospital from July 2013 to June 2017. Resting energy expenditure and body composition were measured in the first trimester, second trimester, third trimester and postpartum.ResultsA total of 144 women participated in this study: 103 with normal glucose tolerance and 41 with diabetes. The resting energy expenditure (kcal/day) of pregnant women with normal glucose tolerance was significantly higher in the third trimester (1,644 ± 234) than in the first (1,461 ± 215) and second trimesters (1,491 ± 219), and postpartum (1,419 ± 254), whereas that of pregnant women with diabetes did not significantly change during all periods (1,568 ± 404, 1,710 ± 332, 1,716 ± 251, 1,567 ± 249). The resting energy expenditure of women with good glycemic control was lower than that of women with poor control. Fat‐free mass was closely correlated with resting energy expenditure.ConclusionsThe resting energy expenditure of Japanese pregnant women with normal glucose tolerance was significantly increased in the third trimester. The resting energy expenditure of women with good glycemic control was lower than that of women with poor control. Resting energy expenditure and fat‐free mass are potential indexes for medical nutrition therapy in pregnant women with diabetes.

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Section: Discussionsupporting

confidence: 85%

Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes

Eto

Maki

Tamada

et al. 2018

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

“…These factors are mainly determined by body size, food intake, physical activity and body composition. Body fat has a five‐fold lower contribution to resting energy expenditure compared to that of fat‐free mass, ~3.5 kcal kg −1 day −1 versus ~18 kcal kg −1 day −1 respectively (Browning & Evans, ; Wang et al., ). In the present study, kittens with a higher BCS also had a higher body fat percentage.…”

Section: Discussionmentioning

confidence: 99%

Food intake and energy expenditure in growing cats with and without a predisposition to overweight

Ghielmetti

Wichert

Rüegg

et al. 2018

Animal Physiology Nutrition

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Overweight and obesity are multifactorial diseases caused by an imbalance in energy metabolism. An underlying genetic predisposition is often a factor in these conditions. In the cat breeding family of the Institute of Animal Nutrition at the Vetsuisse Faculty, University of Zurich, a segregating overweight phenotype with a genetic contribution was observed. From this breeding family, 26 kittens were followed from birth up to 8 months of age. During this time, food intake was measured using an automatic feeding station, and energy expenditure was investigated using indirect calorimetry at the ages of 4 and 6 months. Dual-energy X-ray absorptiometry (DEXA) was performed and blood glucose, leptin and insulin were measured at the ages of 4, 6 and 8 months. The kittens were also weighed daily for the first 2 weeks of life, every second day until weaning and once per week until 8 months of age. The body condition score (BCS) was evaluated monthly between 2 and 8 months of age. The main finding of this study is that a predisposition to overweight is connected to a higher food intake early in life, with no significant alterations in energy expenditure. The leptin blood levels were related to body fat percentage, and insulin sensitivity did not seem to be affected.

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“…Skeletal muscle itself comprises about 40% of total body weight and thus contributes substantially to energy expenditure as it is a prominent constituent of RMR [ 9 ]. Furthermore, considering that RMR comprises ~65% of TEE, skeletal muscle mass plays an essential role in determining TEE [ 9 , 10 ]. Paradoxically, while AA seem to have a greater percentage of relative skeletal muscle mass, they exhibit lower RMR making them more susceptible to overnutrition [ 7 , 11 ].…”

Section: Mitochondrial Efficiency Increases Predisposition Of African...mentioning

confidence: 99%

Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance

et al. 2022

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African Americans (AA) are disproportionately burdened by metabolic diseases. While largely unexplored between Caucasian (C) and AA, differences in mitochondrial bioenergetics may provide crucial insight to mechanisms for increased susceptibility to metabolic diseases. AA display lower total energy expenditure and resting metabolic rate compared to C, but paradoxically have a higher amount of skeletal muscle mass, suggestive of inherent energetic efficiency differences between these races. Such adaptations would increase the chances of overnutrition in AA; however, these disparities would not explain the racial difference in insulin resistance (IR) in healthy subjects. Hallmarks associated with insulin resistance (IR), such as reduced mitochondrial oxidative capacity and metabolic inflexibility are present even in healthy AA without a metabolic disease. These adaptations might be influential of mitochondrial “substrate preference” and could play a role in disproportionate IR rates among races. A higher glycolytic flux and provision of shuttles transferring electrons from cytosol to mitochondrial matrix could be a contributing factor in development of IR via heightened reactive oxygen species (ROS) production. This review highlights the above concepts and provides suggestions for future studies that could help delineate molecular premises behind potential impairments in insulin signaling and metabolic disease susceptibility in AA.

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The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

Cited by 17 publications

References 52 publications

Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes

Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes

Food intake and energy expenditure in growing cats with and without a predisposition to overweight

Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance

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