The contribution of efficient production of monozygotic twins to beef cattle breeding

Hashiyada, Y.

doi:10.1262/jrd.2017-096

Cited by 25 publications

(30 citation statements)

References 109 publications

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“…In the years to come, it is therefore likely that the twinning rate will continue to increase in parallel with milk production. While twin births are welcome for the economy of beef cattle breeding [4][5][6], twin pregnancy is not desirable in dairy cattle. With an economic burden of up to $225 per twin pregnancy [7], the risk of pregnancy loss during the first trimester of gestation for cows carrying twins may be three to seven times higher than for cows carrying singletons [1].…”

mentioning

confidence: 99%

Improved embryo survival following follicular drainage of subordinate follicles for twin pregnancy prevention in bi-ovular dairy cows

García-Ispierto

López‐Gatius

2020

Journal of Reproduction and Development

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To prevent twin pregnancies in cattle, a simple transvaginal device can be used for follicular drainage. This study examines embryo survival following follicular drainage of the smaller pre-ovulatory follicle at timed artificial insemination (AI) in cows with a pre-ovulatory follicle in each ovary. The study groups established were a control group of 289 monovular cows, a non-drainage group of 114 bi-ovular cows and a follicular drainage group of 113 bi-ovular cows. All cows undergoing drainage developed a corpus luteum (CL) in the drained ovary. Pregnancy loss was recorded 56 days post-AI in 19.5% of the 149 cows that became pregnant. Pregnancy loss in the drainage group cows not suffering heat stress (3.8%) was significantly lower (P < 0.05) than in control non-heat stressed cows (20.9%) and heat-stressed non-drainage group cows (25%). Results indicate that CL induction by follicular drainage for twin pregnancy prevention may reduce the incidence of pregnancy loss.

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mentioning

confidence: 99%

Improved embryo survival following follicular drainage of subordinate follicles for twin pregnancy prevention in bi-ovular dairy cows

García-Ispierto

López‐Gatius

2020

Journal of Reproduction and Development

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“…After Dalcq's work in rat, one study reported the complete development of 9 out of 19 pairs of rat two-cell blastomeres (Matsumoto et al 1989). In cattle, three out of ten twin pairs produced by two-cell blastomere separation and culture were born using either Japanese black or Holstein cattle (Hashiyada 2017). In goat, two out of five pairs created at the two-cell stage were born as pairs (Tsunoda et al 1984).…”

Section: Totipotent and Non-totipotent Blastomeres Found In Early Embmentioning

confidence: 99%

Totipotency continuity from zygote to early blastomeres: a model under revision

et al. 2019

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The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. However, if one asks about the totipotency of blastomeres after one or two zygotic divisions, opinions differ. As it is impossible to determine the individual developmental potency of early blastomeres in an intact embryo, experiments of blastomere isolation were conducted in various species, showing that two-cell blastomeres could give rise to a new organism when sister cells were separated. A mainstream interpretation was that each of the sister mammalian blastomeres was equally totipotent. However, reevaluation of those experiments raised some doubts about the real prevalence of cases in which this interpretation could truly be validated. We compiled experiments that tested the individual developmental potency of early mammalian blastomeres in a cell-autonomous way (i.e. excluding nuclear transfer and chimera production). We then confronted the developmental abilities with reported molecular differences between sister blastomeres. The reevaluated observations were at odds with the mainstream view: A viable two-cell embryo can already include one non-totipotent blastomere. We were, thus, led to propose a revised model for totipotency continuity based on the construction of the zygote as a mosaic, which accounts for differential inheritance of totipotency-relevant components between sister blastomeres. This takes place with no preordained mechanisms that would ensure a reproducible partition. This model, which is compatible with the body of data on regulative properties of mammalian early embryos, aims at tempering the rigid interpretation that discounted maternal constraints on totipotency.Reproduction (2019) 158 R49-R65

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“…It also offers the possibility of selectively propagating a desired characteristic by analyzing the one MZ twin and breeding the other. Monozygotic twins, for instance, have been very useful while searching for aesthetics, such as a high degree of marbling in cattle (Hashiyada, 2017). In addition to these uses, MZ twins are also a highly valuable tool in basic research.…”

Section: More Than Just Breeding Livestock: Utility Of Artificial Twimentioning

confidence: 99%

Multiplying embryos: experimental monozygotic polyembryony in mammals and its uses

Casser

Israel²,

Boiani³

2019

Int. J. Dev. Biol.

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Monozygotic (MZ) polyembryony is a strategy to increase the output of a single zygote, thereby producing more offspring from a limited number of oocytes. However, MZ twins and multiples (multiplets) of mammals occur rarely in nature, while their generation has been more successful experimentally. In this work, we review some of the methodological, biological and field aspects of experimental MZ polyembryony in mammals. First attempts of mechanical bisection of 2-cell stage rodent embryos provided a proof-of-principle for the survival and independent development of both blastomeres. Subsequently, experiments in other species, particularly sheep and bovine, allowed 2 methods of embryo multiplication to become routine: the separation or biopsy of blastomeres from cleavage-stage embryos and the bisection of morulae and blastocysts. We discuss how the preferable stage of bisection and the success rate can be species-specific. The scope that profited most from experimental MZ polyembryony is the production of additional copies of elite livestock individuals, the reduction of interindividual variation in test groups and the possibility of investigating discordant phenotypic traits in the same genomic background, for instance, comparing an affected twin with its healthy co-twin. By contrast, the original motivation for experimental polyembryony – efficiently generating more offspring out of the same zygote – has not been fulfilled yet. Although embryo splitting leads to an increase in quantity, there is a loss of embryo quality, thus, there is no real gain from artificially generated embryos (yet) in the field of medically assisted reproduction. In conclusion, mammalian zygotes have the regulative capacity to be polyembryonic, but this is not obligate.

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The contribution of efficient production of monozygotic twins to beef cattle breeding

Cited by 25 publications

References 109 publications

Improved embryo survival following follicular drainage of subordinate follicles for twin pregnancy prevention in bi-ovular dairy cows

Improved embryo survival following follicular drainage of subordinate follicles for twin pregnancy prevention in bi-ovular dairy cows

Totipotency continuity from zygote to early blastomeres: a model under revision

Multiplying embryos: experimental monozygotic polyembryony in mammals and its uses

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