The Contribution of DOPA to Substrate–Peptide Adhesion and Internal Cohesion of Mussel‐Inspired Synthetic Peptide Films

Anderson, Travers H.; Yu, Jing; Estrada, Abril; Hammer, Malte U.; Waite, J. Herbert; Israelachvili, Jacob N.

doi:10.1002/adfm.201000932

Cited by 332 publications

(327 citation statements)

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“…Particularly interesting was the identification of plaque enzymes including tyrosinase, superoxide dismutase, amino oxidase, glycosyl‐hydrolase and peroxidase. DOPA is a common post‐translationally modified tyrosine in mussels, and thus the presence of tyrosinase enzymes is expected: eight such enzymes were found, oxidizing tyrosine to DOPA and further DOPA to o‐quinone leading to tanning, which has been proposed to play a focal role in mussel adhesion and cohesion (Waite et al ., 2005; Anderson et al ., 2010; Niklisch & Waite, 2012). The identified peroxidase enzymes may also be part of this redox balance system.…”

Section: Comparison Of Cement With Other Biological Adhesivesmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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The majority of ticks in the family Ixodidae secrete a substance anchoring their mouthparts to the host skin. This substance is termed cement. It has adhesive properties and seals the lesion during feeding. The particular chemical composition and the curing process of the cement are unclear. This review summarizes the literature, starting with a historical overview, briefly introducing the different hypotheses on the origin of the adhesive and how the tick salivary glands have been identified as its source. Details on the sequence of cement deposition, the curing process and detachment are provided. Other possible functions of the cement, such as protection from the host immune system and antimicrobial properties, are presented. Histochemical and ultrastructural data of the intracellular granules in the salivary gland cells, as well as the secreted cement, suggest that proteins constitute the main material, with biochemical data revealing glycine to be the dominant amino acid. Applied methods and their restrictions are discussed. Tick cement is compared with adhesives of other animals such as barnacles, mussels and sea urchins. Finally, we address the potential of tick cement for the field of biomaterial research and in particular for medical applications in future.

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Section: Comparison Of Cement With Other Biological Adhesivesmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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“…( Anderson et al, 2010;Lin et al, 2007). The SFA has the potential to measure how changing seawater chemistry affects the surface energy of mica, and how interfacial energy affects the performance of adhesive molecules (Yu et al, 2011;Hwang et al, 2010).…”

Section: J H Waite and C C Broomellmentioning

confidence: 99%

Changing environments and structure–property relationships in marine biomaterials

Waite

Broomell

2012

Journal of Experimental Biology

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survival measures might produce inferior biomaterials; (2) during an abrupt and extreme environmental stress, one or more factors (e.g. waves and acidic run-off) might combine to briefly undermine the performance of materials in service, or (3) during a sustained change in the environment that is not physiologically stressful, the quality of normal biomaterials might deteriorate (Fig.1). To date, it remains unknown whether the first, second, third, or some combination of the three represents the most realistic perturbation of biomaterials serving an individual or community.Of the many different properties exhibited by extra-organismic biomaterials in the extended organism, many research groups including ours have focused on those with mechanical or load bearing properties. These are necessary in biomaterials that function in, for example, support, shelter, feeding, prey capture and adhesion. This review is about structure-function relationships in the load-bearing biomaterials of extended organisms and the hypothesis that the functional performance of biomaterials is linked to structures that are perturbed by a changing environment. The proposition is somewhat rhetorical because the toolkits to properly test it are incomplete and few are suited to field ecology. Notwithstanding this, the overview will briefly survey old and new techniques for studying structures and mechanical properties in marine biomaterials, survey how different test conditions affect structure and function in byssal threads, and speculate on what these studies might contribute to ecomechanics. Approaches to structure-function analysisA major goal in experimental biology is discovering relationships between structure and function. This goal is equally relevant to studying biomaterials, except that mechanical properties are used as proxies for function. It is understood that the measured mechanical properties may only be one of many in a multifunctional material. The conventional wisdom in materials science is that structure determines properties; thus, altering structure is likely to alter Accepted 31 May 2011 Summary Most marine organisms make functional biomolecular materials that extend to varying degrees ʻbeyond their skinsʼ. These materials are very diverse and include shells, spines, frustules, tubes, mucus trails, egg capsules and byssal threads, to mention a few. Because they are devoid of cells, these materials lack the dynamic maintenance afforded intra-organismic tissues and thus are usually assumed to be inherently more durable than their internalized counterparts. Recent advances in nanomechanics and submicron spectroscopic imaging have enabled the characterization of structure-property relationships in a variety of extraorganismic materials and provided important new insights about their adaptive functions and stability. Some structure-property relationships in byssal threads are described to show how available analytical methods can reveal hitherto unappreciated interdependences between these materials and their prevailing che...

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“…Previous studies have proposed that the self-healing adhesion of catechol-functionalized polymers and proteins relies on the bidentate hydrogen bonding of catechols as well as on hydrophobic contributions 13,20,28 . If the same is true for catecholic polyacrylates, then molecular and polymer mobility should be important contributing factors.…”

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Surface-initiated self-healing of polymers in aqueous media

et al. 2014

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Polymeric materials that intrinsically heal at damage sites under wet or moist conditions are urgently needed for biomedical and environmental applications [1][2][3][4][5][6] . Although hydrogels with self-mending properties have been engineered by means of mussel-inspired metal-chelating catechol-functionalized polymer networks 7-10 , biological self-healing in wet conditions, as occurs in self-assembled holdfast proteins in mussels and other marine organisms 11,12 , is generally thought to involve more than reversible metal chelates. Here we demonstrate self-mending in metal-free water of synthetic polyacrylate and polymethacrylate materials that are surface-functionalized with mussel-inspired catechols. Wet self-mending of scission in these polymers is initiated and accelerated by hydrogen bonding between interfacial catechol moieties, and consolidated by the recruitment of other non-covalent interactions contributed by subsurface moieties. The repaired and pristine samples show similar mechanical properties, suggesting that the triggering of complete self-healing is enabled underwater by the formation of extensive catechol-mediated interfacial hydrogen bonds.All polymeric materials suffer damage in the course of their functional lifetimes. Few, if any, completely heal at damage sites. Despite recent progress in the design of self-mending polymeric materials based on crack-activated crosslinking 1 , light 2 , heat 3 or other external stimuli 4 , these remain less than perfectly healed, and, in the case of polymers in wet environments, self-healing technologies are even more limited than those engineered for dry conditions. Mussel adhesive holdfasts exhibit significant self-healing capabilities 11,12 , although the molecular mechanisms involved are poorly understood. Notwithstanding this, the selfmending adhesion and cohesion of isolated dopa (3,4-dihydroxyphenyl-L-alanine)-containing adhesive proteins were shown to rely critically on maintaining dopa in an acidic and reducing environment 13,14 . Significantly different conditions are required to recapitulate the self-healing cohesion of tris-dopa-Fe 3+ -mediated complexes in proteins and polymers [7][8][9]15 . Such results increasingly suggest the importance of dopa, but also its subtle and diverse interfacial reactivity vis-à-vis the traditional and still widely held view that dopa, and catechols generally, function primarily as crosslinkers after their 2-electron oxidation to quinones 16 . To better assess the contribution of catechol to polymer selfhealing in a reducing (pH 3), metal-free wet environment, we prepared a material from common, water-insoluble synthetic acrylic polymers having a catechol-functionalized surface. These materials are completely self-healing in a process initiated by catecholmediated interfacial hydrogen bonding, and consolidated by followup interactions (for example, hydrophobic and steric) after a brief compression (∼6 × 10 4 Pa). The crucial and robust roles played by

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The Contribution of DOPA to Substrate–Peptide Adhesion and Internal Cohesion of Mussel‐Inspired Synthetic Peptide Films

Cited by 332 publications

References 42 publications

Tick attachment cement – reviewing the mysteries of a biological skin plug system

Tick attachment cement – reviewing the mysteries of a biological skin plug system

Changing environments and structure–property relationships in marine biomaterials

Surface-initiated self-healing of polymers in aqueous media

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